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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CX3CR1 mRNA | CTD | PMID:21570461 | 2-butoxyethanol | decreases expression | EXP | | 6480464 | n-butoxyethanol results in decreased expression of CX3CR1 mRNA | CTD | PMID:19812364 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CX3CR1 mRNA | CTD | PMID:20188158 | ammonium chloride | affects expression | ISO | RGD:620137 | 6480464 | Ammonium Chloride affects the expression of CX3CR1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CX3CR1 mRNA | CTD | PMID:21569818 | choline | affects expression | ISO | RGD:1352124 | 6480464 | Choline affects the expression of CX3CR1 mRNA | CTD | PMID:17616785 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA | CTD | PMID:20938992 | cyclophosphamide | increases expression | ISO | RGD:620137 | 6480464 | Cyclophosphamide results in increased expression of CX3CR1 protein | CTD | PMID:16651033 | dioxygen | increases expression | ISO | RGD:1352124 | 6480464 | Oxygen deficiency results in increased expression of CX3CR1 mRNA; more ... | CTD | PMID:17476338 | disodium selenite | decreases expression | ISO | RGD:1352124 | 6480464 | Sodium Selenite results in decreased expression of CX3CR1 mRNA | CTD | PMID:18175754 | divanadium pentaoxide | increases expression | ISO | RGD:1352124 | 6480464 | vanadium pentoxide results in increased expression of CX3CR1 mRNA | CTD | PMID:17459161 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA | CTD | PMID:20938992 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA | CTD | PMID:20938992 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of CX3CR1 mRNA | CTD | PMID:21829687 | paracetamol | multiple interactions | EXP | | 6480464 | [MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CR1 mRNA | CTD | PMID:22575169 | phenobarbital | increases expression | ISO | RGD:1352124 | 6480464 | Phenobarbital results in increased expression of CX3CR1 mRNA | CTD | PMID:19084549 | rosiglitazone | affects localization | ISO | RGD:1352124 | 6480464 | rosiglitazone affects the localization of CX3CR1 protein | CTD | PMID:19850645 | rosiglitazone | decreases expression | EXP | | 6480464 | rosiglitazone results in decreased expression of CX3CR1 mRNA | CTD | PMID:19850645 | rosiglitazone | multiple interactions | EXP | | 6480464 | PPARG affects the reaction [rosiglitazone results in decreased expression of CX3CR1 mRNA] | CTD | PMID:19850645 | rosiglitazone | decreases expression | ISO | RGD:1352124 | 6480464 | rosiglitazone results in decreased expression of CX3CR1 mRNA | CTD | PMID:19850645 | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide results in decreased expression of CX3CR1 mRNA | CTD | PMID:19073995 | simvastatin | decreases expression | ISO | RGD:1352124 | 6480464 | Simvastatin results in decreased expression of CX3CR1 mRNA | CTD | PMID:18359719 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CX3CR1 mRNA | CTD | PMID:21641980 | trichloroethene | multiple interactions | EXP | | 6480464 | PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of CX3CR1 mRNA] | CTD | PMID:15363585 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
Phenotype Annotations
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MGD data from the GO Consortium |
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MGD IEA |
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Rauer M, etal., J Neurovirol. 2002 Jan;8(3):168-79. |
| 28. |
RGD automated import pipeline |
| 29. |
RGD automated import pipeline for gene-chemical interactions |
| 30. |
RGD Automated Pipelines |
| 31. |
Ruth JH, etal., Arthritis Rheum. 2001 Jul;44(7):1568-81. |
| 32. |
Shan S, etal., Neurobiol Aging. 2009 Apr 14. |
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Yin Q, etal., Behav Pharmacol. 2010 Oct;21(7):595-601. |
| 39. |
Yuridullah R, etal., Auton Neurosci. 2006 Jun 30;126-127:380-9. Epub 2006 May 2. |
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RGD Disease Portals| Cx3cr1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cx3cr1 (Mus musculus) |
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| CX3CR1 (Homo sapiens) |
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| Cx3cr1 (Rattus norvegicus) |
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Position Markers| PMC209384P1 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_009987 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01082391 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01082392 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01082393 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01082394 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01082395 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01082396 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC117245 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF074912 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF102269 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK035902 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK044557 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK045634 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK137388 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK140010 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC012653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466587 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ360291 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ360292 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_009987 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_034117 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_034117 | (Get FASTA) |
| GenBank Protein | AAC72408 | (Get FASTA) |
| AAD08665 | (Get FASTA) | |
| AAH12653 | (Get FASTA) | |
| ABC95973 | (Get FASTA) | |
| ABC95975 | (Get FASTA) | |
| BAC29236 | (Get FASTA) | |
| BAC31979 | (Get FASTA) | |
| BAC32440 | (Get FASTA) | |
| BAE23340 | (Get FASTA) | |
| BAE24210 | (Get FASTA) | |
| EDL09189 | (Get FASTA) | |
| Q9Z0D9 | (Get FASTA) |
Promoters| RGD ID: | 6844381 | ||||||||||
| Promoter ID: | MM_KWN:59158 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_0Hour | ||||||||||
| Transcripts: | NM_009987 | ||||||||||
| Position: |
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| RGD ID: | 6883870 | ||||||||||
| Promoter ID: | EPDNEW_M5386 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Cx3cr1_1 | ||||||||||
| Description: | chemokine (C-X3-C) receptor 1 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000052336 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000063986 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000064165 | ENTREZGENE |
| Entrez Gene | 13051 | ENTREZGENE |
| HomoloGene Group ID | 20350 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| Chemokine_fractalkine_CX3CR1 | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00128996 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:13051 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1333815 | ENTREZGENE |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | FRACTALKINER | UniProtKB/Swiss-Prot |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.44065 | ENTREZGENE |
| UniProt | CX3C1_MOUSE | UniProtKB/Swiss-Prot |
| Q543X3_MOUSE | UniProtKB/TrEMBL | |
| Q8BR50_MOUSE | UniProtKB/TrEMBL | |
| Q8CBJ0_MOUSE | UniProtKB/TrEMBL |
| More on Cx3cr1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1552004 |
| Created: | 2005-09-30 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




