RGD Reference Report - Ischemia-induced increase in microvascular phosphodiesterase 4D expression in rat hippocampus associated with blood brain barrier permeability: effect of age. - Rat Genome Database

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Ischemia-induced increase in microvascular phosphodiesterase 4D expression in rat hippocampus associated with blood brain barrier permeability: effect of age.

Authors: He, Z  He, B  Behrle, BL  Fejleh, MP  Cui, L  Paule, MG  Greenfield, LJ 
Citation: He Z, etal., ACS Chem Neurosci. 2012 Jun 20;3(6):428-32. doi: 10.1021/cn2001156. Epub 2012 Feb 27.
RGD ID: 7327148
Pubmed: PMID:22860212   (View Abstract at PubMed)
PMCID: PMC3400376   (View Article at PubMed Central)
DOI: DOI:10.1021/cn2001156   (Journal Full-text)

Phosphodiesterase 4D (PDE4D) is one of 16 PDEs expressed in cerebral microvessels, and may be involved in regulating blood-brain barrier (BBB) permeability. To assess the possible role of PDE4D in stroke-related injury in young versus aged rats, we measured microvascular PDE4D expression, parenchymal albumin immunoreactivity, and changes in the inside bore of the brain microvasculature. Ischemia caused severe hippocampal CA1 damage, associated with significant increases in vascular PDE4D and parenchymal albumin immunoreactivities. This effect was greater in the younger animals, which also had a greater increase in PDE4D expression. Ischemia significantly decreased tissue density in the perimicrovascular space in both young and aged animals. In addition, internal bore circumference and cross-sectional area of the hippocampal microvessels increased dramatically following ischemia. Increased PDE4D expression following cerebral ischemia may play a role in changing BBB permeability, which could secondarily affect ischemic outcome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transient cerebral ischemia  ISOPde4d (Rattus norvegicus)7327148; 7327148protein:increased expression:hippocampus CA1 RGD 
transient cerebral ischemia  IEP 7327148protein:increased expression:hippocampus CA1 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pde4d  (phosphodiesterase 4D)

Genes (Mus musculus)
Pde4d  (phosphodiesterase 4D, cAMP specific)

Genes (Homo sapiens)
PDE4D  (phosphodiesterase 4D)


Additional Information