Jak1 (Janus kinase 1) - Rat Genome Database

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Gene: Jak1 (Janus kinase 1) Mus musculus
Analyze
Symbol: Jak1
Name: Janus kinase 1
RGD ID: 69103
MGI Page MGI
Description: Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cellular response to cytokine stimulus; enzyme-linked receptor protein signaling pathway; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytoplasmic side of plasma membrane and cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA960307; BAP0; BAP004; C130039L05Rik; JAK-1; MGC37919; tyrosine-protein kinase JAK1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,009,171 - 101,122,493 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,009,564 - 101,122,479 (-)EnsemblGRCm39 Ensembl
GRCm384101,151,974 - 101,265,282 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,152,367 - 101,265,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv374100,824,579 - 100,937,887 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364100,650,964 - 100,763,165 (-)NCBIMGSCv36mm8
Celera499,494,673 - 99,536,518 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (EXP)
amantadine  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
baricitinib  (ISO)
Benoxacor  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capillarisin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
Cirsimarin  (EXP)
cisplatin  (EXP)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
clozapine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyanidin cation  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
DDT  (ISO)
deoxynivalenol  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
Fidarestat  (ISO)
filipin III  (ISO)
gentamycin  (ISO)
hesperetin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
inulin  (EXP)
isotretinoin  (ISO)
L-ethionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
luteolin  (EXP)
lycopene  (ISO)
menadione  (EXP)
mercury dichloride  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP)
myricetin  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
Nonylphenol  (EXP)
oleic acid  (ISO)
omeprazole  (ISO)
oridonin  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pipoxolan  (EXP)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
Punicalagin  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (EXP,ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
tofacitinib  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimethyltin  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
verteporfin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal bone resorption  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal circulating creatinine level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver vasculature morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal plasma cell morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal tail morphology  (IAGP)
alopecia  (IAGP)
anisocytosis  (IAGP)
apnea  (IAGP)
arrested B cell differentiation  (IAGP)
decreased B cell number  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cellular hemoglobin content  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating total protein level  (IAGP)
decreased compact bone volume  (IAGP)
decreased fetal size  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased mean platelet volume  (IAGP)
decreased megakaryocyte cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased triglyceride level  (IAGP)
decreased urine urea nitrogen level  (IAGP)
dilated liver sinusoidal space  (IAGP)
ear inflammation  (IAGP)
enhanced liver regeneration  (IAGP)
enlarged spleen  (IAGP)
hypoglycemia  (IAGP)
increased alkaline phosphatase activity  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased blood uric acid level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating calcium level  (IAGP)
increased double-negative T cell number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased plasma cell number  (IAGP)
liver hyperplasia  (IAGP)
microcytic anemia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small thymus  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion. Albacker LA, etal., PLoS One. 2017 Nov 9;12(11):e0176181. doi: 10.1371/journal.pone.0176181. eCollection 2017.
2. JAK1 gene polymorphisms are associated with the outcomes of hepatitis B virus infection, but not with α interferon therapy response in a Han Chinese population. Chen K, etal., Genet Test Mol Biomarkers. 2012 Oct;16(10):1206-10. doi: 10.1089/gtmb.2012.0141. Epub 2012 Aug 17.
3. Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway. Chen L, etal., Oncol Rep. 2018 Mar;39(3):1081-1089. doi: 10.3892/or.2018.6198. Epub 2018 Jan 8.
4. The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity. Chen P, etal., Int J Mol Med. 2011 May;27(5):731-8. doi: 10.3892/ijmm.2011.632. Epub 2011 Mar 1.
5. Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor. Chough C, etal., Bioorg Med Chem. 2018 May 1;26(8):1495-1510. doi: 10.1016/j.bmc.2018.01.021. Epub 2018 Feb 3.
6. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Jeong EG, etal., Clin Cancer Res. 2008 Jun 15;14(12):3716-21. doi: 10.1158/1078-0432.CCR-07-4839.
7. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
8. Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes. Justicia C, etal., Glia. 2000 May;30(3):253-70. doi: 10.1002/(sici)1098-1136(200005)30:3<253::aid-glia5>3.0.co;2-o.
9. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Kan Z, etal., Genome Res. 2013 Sep;23(9):1422-33. doi: 10.1101/gr.154492.113. Epub 2013 Jun 20.
10. Mangiferin ameliorates Porphyromonas gingivalis-induced experimental periodontitis by inhibiting phosphorylation of nuclear factor-κB and Janus kinase 1-signal transducer and activator of transcription signaling pathways. Li H, etal., J Periodontal Res. 2017 Feb;52(1):1-7. doi: 10.1111/jre.12360. Epub 2016 Jan 30.
11. Corilagin ameliorates schistosomiasis hepatic fibrosis through regulating IL-13 associated signal pathway in vitro and in vivo. Li HR, etal., Parasitology. 2016 Oct;143(12):1629-38. doi: 10.1017/S0031182016001128. Epub 2016 Jul 21.
12. Activation of Janus kinase 1 confers poor prognosis in patients with non-small cell lung cancer. Liu D, etal., Oncol Lett. 2017 Oct;14(4):3959-3966. doi: 10.3892/ol.2017.6690. Epub 2017 Aug 1.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Biology of interleukin-10. Sabat R, etal., Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. doi: 10.1016/j.cytogfr.2010.09.002. Epub 2010 Nov 5.
24. Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1. Sveen A, etal., Genome Med. 2017 May 24;9(1):46. doi: 10.1186/s13073-017-0434-0.
25. [Changes of interleukin-6 and Janus kinases in rats with hypoxic pulmonary hypertension]. Wang GS, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2003 Nov;26(11):664-7.
26. Knockdown of Linc00052 alleviated spinal nerve ligation-triggered neuropathic pain through regulating miR-448 and JAK1. Wang L, etal., J Cell Physiol. 2020 Oct;235(10):6528-6535. doi: 10.1002/jcp.29465. Epub 2020 Feb 3.
27. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. Wang Q, etal., J Steroid Biochem Mol Biol. 2013 May;135:43-50. doi: 10.1016/j.jsbmb.2013.01.008. Epub 2013 Jan 18.
28. Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer. Wen W, etal., Mol Cancer Ther. 2014 Dec;13(12):3037-48. doi: 10.1158/1535-7163.MCT-14-0077. Epub 2014 Oct 15.
29. Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma. Yang S, etal., Oncotarget. 2016 Feb 2;7(5):5461-9. doi: 10.18632/oncotarget.6684.
30. MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway. Yu DL, etal., Oncol Rep. 2017 Aug;38(2):1075-1082. doi: 10.3892/or.2017.5781. Epub 2017 Jul 3.
31. Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population. Zhou F, etal., Oncotarget. 2016 May 10;7(19):28112-23. doi: 10.18632/oncotarget.8492.
Additional References at PubMed
PMID:1581631   PMID:1848670   PMID:2466296   PMID:2482828   PMID:7490523   PMID:7539296   PMID:7542761   PMID:7544789   PMID:7579387   PMID:7589562   PMID:7613027   PMID:7657660  
PMID:7713924   PMID:7796811   PMID:7893599   PMID:7929391   PMID:8022486   PMID:8272873   PMID:8331382   PMID:8378315   PMID:8514334   PMID:8535092   PMID:8593242   PMID:8608597  
PMID:8662243   PMID:8889548   PMID:8918879   PMID:8934548   PMID:9229117   PMID:9342212   PMID:9360952   PMID:9492017   PMID:9524251   PMID:9548458   PMID:9553136   PMID:9590172  
PMID:9638363   PMID:9774693   PMID:9889194   PMID:10200816   PMID:10349636   PMID:10374907   PMID:10502458   PMID:10526570   PMID:10781830   PMID:10872802   PMID:10922068   PMID:10932192  
PMID:11042159   PMID:11058581   PMID:11076861   PMID:11114734   PMID:11217851   PMID:11390995   PMID:11437454   PMID:12477932   PMID:12520002   PMID:12576323   PMID:12738762   PMID:15254900  
PMID:15456882   PMID:15526032   PMID:15659653   PMID:15677447   PMID:15782199   PMID:15923602   PMID:15988755   PMID:16141072   PMID:16141073   PMID:16280321   PMID:16417589   PMID:16602821  
PMID:16737695   PMID:17114464   PMID:17550976   PMID:17855365   PMID:17873904   PMID:17908914   PMID:17928529   PMID:18178840   PMID:18287559   PMID:18362173   PMID:18451094   PMID:18718058  
PMID:18799693   PMID:18948751   PMID:18995957   PMID:19056487   PMID:19075017   PMID:19103753   PMID:19139102   PMID:19361784   PMID:19620279   PMID:19887489   PMID:20372968   PMID:20505761  
PMID:20564237   PMID:20641039   PMID:20846526   PMID:20974963   PMID:21155952   PMID:21160051   PMID:21267068   PMID:21383241   PMID:21393331   PMID:21873635   PMID:22284677   PMID:22402124  
PMID:22467218   PMID:22527485   PMID:22972935   PMID:23526587   PMID:23791841   PMID:23990909   PMID:24048415   PMID:24152426   PMID:24169825   PMID:24365136   PMID:24398427   PMID:24732911  
PMID:24859004   PMID:25057888   PMID:25113558   PMID:25156366   PMID:25193870   PMID:25352124   PMID:25959715   PMID:25977345   PMID:26370502   PMID:26764350   PMID:26864813   PMID:27029485  
PMID:27044867   PMID:27088444   PMID:27103069   PMID:27111231   PMID:27222478   PMID:27318131   PMID:27383175   PMID:27436342   PMID:27440725   PMID:27480124   PMID:27671227   PMID:27905037  
PMID:27919027   PMID:28154170   PMID:28191885   PMID:28278176   PMID:28378742   PMID:28723893   PMID:28784777   PMID:28901399   PMID:28965767   PMID:29242197   PMID:29308566   PMID:29345196  
PMID:29581031   PMID:29668931   PMID:29692363   PMID:30066904   PMID:30463015   PMID:30671064   PMID:30837996   PMID:31197234   PMID:31305264   PMID:31346084   PMID:31556112   PMID:32098917  
PMID:32325033   PMID:32397290   PMID:32814877   PMID:33042133   PMID:33475190   PMID:33811972   PMID:34118090   PMID:34498493   PMID:34515136   PMID:34675248   PMID:35046931   PMID:35196494  
PMID:35382859   PMID:35493520   PMID:35545774   PMID:36114006   PMID:36639058   PMID:37080331   PMID:37824022  


Genomics

Comparative Map Data
Jak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,009,171 - 101,122,493 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,009,564 - 101,122,479 (-)EnsemblGRCm39 Ensembl
GRCm384101,151,974 - 101,265,282 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,152,367 - 101,265,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv374100,824,579 - 100,937,887 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364100,650,964 - 100,763,165 (-)NCBIMGSCv36mm8
Celera499,494,673 - 99,536,518 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.19NCBI
JAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,833,229 - 65,067,746 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,833,223 - 65,067,754 (-)EnsemblGRCh38hg38GRCh38
GRCh37165,298,912 - 65,533,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,071,494 - 65,204,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 34165,012,228 - 65,064,007NCBI
Celera163,589,792 - 63,723,086 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef163,407,815 - 63,541,120 (-)NCBIHuRef
CHM1_1165,415,253 - 65,548,498 (-)NCBICHM1_1
T2T-CHM13v2.0164,711,228 - 64,945,755 (-)NCBIT2T-CHM13v2.0
Jak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85120,895,606 - 121,004,207 (-)NCBIGRCr8
mRatBN7.25115,780,248 - 115,888,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5115,780,248 - 115,888,926 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5118,339,384 - 118,439,691 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,064,750 - 120,165,057 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,116,031 - 120,216,334 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05119,982,503 - 120,091,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5119,982,943 - 120,083,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05123,865,078 - 123,973,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45121,804,586 - 121,905,581 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15121,813,666 - 121,843,676 (-)NCBI
Celera5114,318,185 - 114,418,922 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,524,075 - 25,580,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542325,501,989 - 25,581,826 (+)NCBIChiLan1.0ChiLan1.0
JAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21161,893,702 - 162,026,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,944,411 - 161,177,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,083,562 - 64,315,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1165,972,568 - 66,025,070 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl165,973,904 - 66,024,991 (-)Ensemblpanpan1.1panPan2
JAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1545,251,653 - 45,408,571 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl545,251,653 - 45,408,571 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha545,310,150 - 45,467,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0545,434,808 - 45,591,981 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl545,434,808 - 45,596,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1545,401,193 - 45,555,602 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0545,345,182 - 45,501,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,594,991 - 45,751,867 (+)NCBIUU_Cfam_GSD_1.0
Jak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505877,982,726 - 78,038,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366922,299,504 - 2,354,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366922,298,149 - 2,354,084 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6147,429,056 - 147,567,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16147,320,288 - 147,567,188 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26135,899,431 - 135,917,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12068,122,134 - 68,253,361 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2068,122,173 - 68,252,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603349,273,104 - 49,510,023 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474229,689,965 - 29,723,981 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474229,631,391 - 29,723,981 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Jak1
3692 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1986
Count of miRNA genes:761
Interacting mature miRNAs:979
Transcripts:ENSMUST00000102781, ENSMUST00000125968, ENSMUST00000132292, ENSMUST00000136167, ENSMUST00000147211, ENSMUST00000149297, ENSMUST00000151235, ENSMUST00000155328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468018237107157197Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1302057Pgia27_mproteoglycan induced arthritis 27 (mouse)Not determined470067227104067464Mouse
12879897Berr4_mberghei resistance locus 4 (mouse)471982069105982216Mouse
1302044Nss1_mNOD Sjogren's syndrome 1 (mouse)Not determined471982069105982216Mouse
1301739Pitm2_mprion incubation time 2 (mouse)Not determined471982069105982216Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474033887108034029Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474444699108444983Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474444699108444983Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474444699108444983Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474444699108444983Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474444699108444983Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474444699108444983Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474444699108444983Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474444699108444983Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474444699108444983Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474444699108444983Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474718237108357197Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483118237108357197Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)484918237107157197Mouse
26884435Zlq4_mzygomatic length QTL 4, 10 week (mouse)485118237104957197Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
27226801Feml6_mfemur length 6, 5 week (mouse)487518237103257197Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487518237107157197Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487518237108357197Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488118237108357197Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488518237108357197Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488518237108457197Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)490888237108457197Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)496888237111857197Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse

Markers in Region
40.MMHAP29FLF4.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384101,250,064 - 101,250,214UniSTSGRCm38
MGSCv374100,922,669 - 100,922,819UniSTSGRCm37
Celera499,592,696 - 99,592,846UniSTS
Cytogenetic Map4C6UniSTS
cM Map446.3UniSTS
Whitehead_YAC4 UniSTS
D4Mit305  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384101,256,124 - 101,256,233UniSTSGRCm38
MGSCv374100,928,729 - 100,928,838UniSTSGRCm37
Celera499,598,737 - 99,598,846UniSTS
Cytogenetic Map4C6UniSTS
cM Map449.6UniSTS
Whitehead Genetic448.1UniSTS
AA960307  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384101,152,513 - 101,152,626UniSTSGRCm38
MGSCv374100,825,118 - 100,825,231UniSTSGRCm37
Celera499,495,212 - 99,495,325UniSTS
Cytogenetic Map4C6UniSTS
cM Map446.3UniSTS
Whitehead/MRC_RH41411.94UniSTS
Jak1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384101,153,175 - 101,153,322UniSTSGRCm38
GRCm384101,153,175 - 101,153,356UniSTSGRCm38
MGSCv374100,825,780 - 100,825,927UniSTSGRCm37
MGSCv374100,825,780 - 100,825,961UniSTSGRCm37
Celera499,495,874 - 99,496,055UniSTS
Celera499,495,874 - 99,496,021UniSTS
Cytogenetic Map4C6UniSTS
cM Map446.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_146145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK029232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S63728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000102781   ⟹   ENSMUSP00000099842
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,009,564 - 101,122,479 (-)Ensembl
GRCm38.p6 Ensembl4101,152,367 - 101,265,282 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,055,035 - 101,122,423 (-)Ensembl
GRCm38.p6 Ensembl4101,197,838 - 101,265,226 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,039,109 - 101,122,420 (-)Ensembl
GRCm38.p6 Ensembl4101,181,912 - 101,265,223 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136167
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,036,788 - 101,042,622 (-)Ensembl
GRCm38.p6 Ensembl4101,179,591 - 101,185,425 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,038,216 - 101,042,647 (-)Ensembl
GRCm38.p6 Ensembl4101,181,019 - 101,185,450 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149297   ⟹   ENSMUSP00000122957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,048,823 - 101,122,470 (-)Ensembl
GRCm38.p6 Ensembl4101,191,626 - 101,265,273 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,011,446 - 101,012,316 (-)Ensembl
GRCm38.p6 Ensembl4101,154,249 - 101,155,119 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,039,069 - 101,122,478 (-)Ensembl
GRCm38.p6 Ensembl4101,181,872 - 101,265,281 (-)Ensembl
RefSeq Acc Id: NM_013567   ⟹   NP_038595
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,565 - 101,122,420 (-)NCBI
GRCm384101,152,368 - 101,265,223 (-)NCBI
Sequence:
RefSeq Acc Id: NM_146145   ⟹   NP_666257
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,171 - 101,122,479 (-)NCBI
GRCm384101,151,974 - 101,265,282 (-)NCBI
MGSCv374100,824,579 - 100,937,887 (-)RGD
Celera499,494,673 - 99,536,518 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502812   ⟹   XP_006502875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,564 - 101,122,322 (-)NCBI
GRCm384101,152,367 - 101,265,124 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253262   ⟹   XP_030109122
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,564 - 101,122,321 (-)NCBI
GRCm384101,152,367 - 101,265,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253263   ⟹   XP_030109123
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,564 - 101,122,493 (-)NCBI
GRCm384101,152,367 - 101,265,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253265   ⟹   XP_030109125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,564 - 101,122,324 (-)NCBI
GRCm384101,152,367 - 101,191,564 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163741   ⟹   XP_036019634
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,009,564 - 101,122,441 (-)NCBI
Sequence:
RefSeq Acc Id: NP_666257   ⟸   NM_146145
- Peptide Label: isoform 1
- UniProtKB: B1ASP2 (UniProtKB/TrEMBL),   Q3URU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502875   ⟸   XM_006502812
- Peptide Label: isoform X1
- UniProtKB: B1ASP2 (UniProtKB/TrEMBL),   Q3URU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030109123   ⟸   XM_030253263
- Peptide Label: isoform X1
- UniProtKB: B1ASP2 (UniProtKB/TrEMBL),   Q3URU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030109122   ⟸   XM_030253262
- Peptide Label: isoform X1
- UniProtKB: B1ASP2 (UniProtKB/TrEMBL),   Q3URU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030109125   ⟸   XM_030253265
- Peptide Label: isoform X2
- UniProtKB: Q8K0I7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_038595   ⟸   NM_013567
- Peptide Label: isoform 2
- UniProtKB: Q3URU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000122957   ⟸   ENSMUST00000149297
RefSeq Acc Id: ENSMUSP00000099842   ⟸   ENSMUST00000102781
RefSeq Acc Id: XP_036019634   ⟸   XM_036163741
- Peptide Label: isoform X1
- UniProtKB: B1ASP2 (UniProtKB/TrEMBL),   Q3URU8 (UniProtKB/TrEMBL)
Protein Domains
FERM   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52332-F1-model_v2 AlphaFold P52332 1-1153 view protein structure

Promoters
RGD ID:6835522
Promoter ID:MM_KWN:38644
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000018656
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364100,827,331 - 100,828,627 (-)MPROMDB
RGD ID:6835520
Promoter ID:MM_KWN:38645
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Brain,   Liver,   Lung
Transcripts:OTTMUST00000018650,   OTTMUST00000018651
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364100,856,981 - 100,858,982 (-)MPROMDB
RGD ID:6835521
Promoter ID:MM_KWN:38648
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_146145,   OTTMUST00000018652,   OTTMUST00000018653,   OTTMUST00000018654,   OTTMUST00000018655
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364100,937,549 - 100,938,049 (-)MPROMDB
RGD ID:6883956
Promoter ID:EPDNEW_M5429
Type:single initiation site
Name:Jak1_2
Description:Mus musculus Janus kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5430  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384101,216,889 - 101,216,949EPDNEW
RGD ID:6883958
Promoter ID:EPDNEW_M5430
Type:initiation region
Name:Jak1_1
Description:Mus musculus Janus kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5429  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384101,265,223 - 101,265,283EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96628 AgrOrtholog
Ensembl Genes ENSMUSG00000028530 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102781 ENTREZGENE
  ENSMUST00000102781.10 UniProtKB/TrEMBL
  ENSMUST00000149297.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96628 ENTREZGENE
NCBI Gene 16451 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE JAK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FERM_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Jak1 PhenoGen
PIRSF TyrPK_Jak UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JANUSKINASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1ASP2 ENTREZGENE, UniProtKB/TrEMBL
  B1ASP3_MOUSE UniProtKB/TrEMBL
  JAK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TI10_MOUSE UniProtKB/TrEMBL
  Q3U8P8_MOUSE UniProtKB/TrEMBL
  Q3URU8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UZ30_MOUSE UniProtKB/TrEMBL
  Q8CFX4_MOUSE UniProtKB/TrEMBL
  Q8K0I7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q62126 UniProtKB/Swiss-Prot