| 17beta-estradiol | multiple interactions | ISO | RGD:1348463 | 6480464 | Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]; more ... | CTD | PMID:16489025 |
| 17beta-estradiol | multiple interactions | ISO | RGD:620036 | 6480464 | Estradiol promotes the reaction [[EP300 protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA] | CTD | PMID:15774498 |
| 17beta-hydroxy-5alpha-androstan-3-one | multiple interactions | ISO | RGD:1348463 | 6480464 | Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 promoter]; more ... | CTD | PMID:18487222 |
| 17beta-hydroxy-5alpha-androstan-3-one | multiple interactions | ISO | RGD:1348463 | 6480464 | Dihydrotestosterone promotes the reaction [EP300 protein binds to GAS6 promoter] | CTD | PMID:20048160 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1348463 | 6480464 | EP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; more ... | CTD | PMID:18842620 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1348463 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1A1 promoter]; more ... | CTD | PMID:18842620 PMID:21703235 |
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EP300 mRNA | CTD | PMID:21570461 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1348463 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to PTGS2 promoter] | CTD | PMID:19056653 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1348463 | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]] | CTD | PMID:16489025 |
| 2,4-dinitrotoluene | affects expression | ISO | RGD:620036 | 6480464 | 2,4-dinitrotoluene affects the expression of EP300 mRNA | CTD | PMID:21346803 |
| 5-(2-methylpiperazine-1-sulfonyl)isoquinoline | multiple interactions | ISO | RGD:620036 | 6480464 | [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein | CTD | PMID:15767673 |
| 5-(2-methylpiperazine-1-sulfonyl)isoquinoline | increases expression | ISO | RGD:620036 | 6480464 | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 protein | CTD | PMID:15767673 |
| 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:1348463 | 6480464 | decitabine affects the methylation of EP300 promoter | CTD | PMID:17965222 |
| 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1348463 | 6480464 | decitabine promotes the reaction [EP300 protein binds to TP53 protein] | CTD | PMID:17977830 |
| 8-bromo-3',5'-cyclic AMP | decreases expression | ISO | RGD:1348463 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EP300 mRNA | CTD | PMID:22079614 |
| all-trans-retinoic acid | multiple interactions | EXP | | 6480464 | Tretinoin inhibits the reaction [EP300 protein binds to RETN promoter] | CTD | PMID:15047602 |
| all-trans-retinoic acid | multiple interactions | ISO | RGD:1348463 | 6480464 | EP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]; more ... | CTD | PMID:16581781 |
| all-trans-retinyl palmitate | multiple interactions | ISO | RGD:620036 | 6480464 | retinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein] | CTD | PMID:17164434 |
| ammonium chloride | affects expression | ISO | RGD:620036 | 6480464 | Ammonium Chloride affects the expression of EP300 mRNA | CTD | PMID:16483693 |
| amphotericin B | multiple interactions | ISO | RGD:1348463 | 6480464 | Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] | CTD | PMID:16189267 |
| apocynin | multiple interactions | ISO | RGD:1348463 | 6480464 | acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] | CTD | PMID:19281832 |
| bis(2-chloroethyl) sulfide | decreases expression | EXP | | 6480464 | Mustard Gas results in decreased expression of EP300 mRNA | CTD | PMID:18955075 |
| cadmium atom | multiple interactions | EXP | | 6480464 | Cadmium promotes the reaction [MTF1 protein binds to EP300 protein] | CTD | PMID:18458062 |
| calcitriol | affects localization | EXP | | 6480464 | Calcitriol affects the localization of EP300 protein | CTD | PMID:15647825 |
| calcitriol | multiple interactions | EXP | | 6480464 | Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter]; more ... | CTD | PMID:15647825 |
| camptothecin | decreases expression | ISO | RGD:1348463 | 6480464 | Camptothecin results in decreased expression of EP300 mRNA; more ... | CTD | PMID:10344722 |
| chromium atom | increases activity | EXP | | 6480464 | Chromium results in increased activity of EP300 protein | CTD | PMID:21467744 |
| chromium(6+) | multiple interactions | EXP | | 6480464 | chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] | CTD | PMID:18605988 |
| chromium(6+) | multiple interactions | EXP | | 6480464 | EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]] | CTD | PMID:21467744 |
| cisplatin | multiple interactions | ISO | RGD:1348463 | 6480464 | EP300 protein promotes the reaction [Cisplatin results in increased acetylation of APEX1 protein]; more ... | CTD | PMID:20856196 |
| cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of EP300 protein | CTD | PMID:21310163 |
| cisplatin | multiple interactions | EXP | | 6480464 | [PIWIL2 protein co-treated with Cisplatin] results in decreased expression of EP300 protein | CTD | PMID:21310163 |
| cisplatin | decreases expression | ISO | RGD:1348463 | 6480464 | Cisplatin results in decreased expression of EP300 protein | CTD | PMID:17498666 |
| copper atom | multiple interactions | ISO | RGD:620036 | 6480464 | [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein; more ... | CTD | PMID:22276220 |
| copper(0) | multiple interactions | ISO | RGD:620036 | 6480464 | [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein; more ... | CTD | PMID:22276220 |
| copper(2+) sulfate | increases expression | ISO | RGD:1348463 | 6480464 | Copper Sulfate results in increased expression of EP300 mRNA | CTD | PMID:19549813 |
| curcumin | multiple interactions | ISO | RGD:1348463 | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; more ... | CTD | PMID:17927689 |
| curcumin | decreases expression | ISO | RGD:1348463 | 6480464 | Curcumin results in decreased expression of EP300 mRNA; more ... | CTD | PMID:17927689 |
| curcumin | affects localization | ISO | RGD:1348463 | 6480464 | Curcumin affects the localization of EP300 protein | CTD | PMID:17927689 |
| dexamethasone | multiple interactions | ISO | RGD:620036 | 6480464 | EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]; more ... | CTD | PMID:17884810 |
| dexamethasone | multiple interactions | ISO | RGD:1348463 | 6480464 | Dexamethasone promotes the reaction [EP300 protein binds to SLC4A2 promoter]; more ... | CTD | PMID:18188457 |
| diarsenic trioxide | increases activity | ISO | RGD:1348463 | 6480464 | arsenic trioxide results in increased activity of EP300 protein | CTD | PMID:15031205 |
| diarsenic trioxide | increases expression | ISO | RGD:1348463 | 6480464 | arsenic trioxide results in increased expression of EP300 mRNA | CTD | PMID:20458559 |
| diarsenic trioxide | multiple interactions | ISO | RGD:1348463 | 6480464 | arsenic trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein] | CTD | PMID:15031205 |
| diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of EP300 protein | CTD | PMID:15019724 |
| dioxygen | multiple interactions | ISO | RGD:1348463 | 6480464 | Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] | CTD | PMID:16189267 |
| disodium selenite | decreases expression | ISO | RGD:1348463 | 6480464 | Sodium Selenite results in decreased expression of EP300 mRNA; more ... | CTD | PMID:10344722 |
| doxorubicin | decreases expression | ISO | RGD:1348463 | 6480464 | Doxorubicin results in decreased expression of EP300 mRNA | CTD | PMID:10344722 |
| doxorubicin | multiple interactions | ISO | RGD:1348463 | 6480464 | [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin; more ... | CTD | PMID:19047049 |
| doxorubicin | decreases expression | ISO | RGD:1348463 | 6480464 | Doxorubicin results in decreased expression of EP300 protein | CTD | PMID:10344722 PMID:17498666 |
| doxorubicin | decreases expression | ISO | RGD:620036 | 6480464 | Doxorubicin results in decreased expression of EP300 protein | CTD | PMID:15767673 PMID:11073966 |
| doxorubicin | multiple interactions | ISO | RGD:620036 | 6480464 | EP300 inhibits the reaction [Doxorubicin results in decreased expression of MEF2C mRNA] | CTD | PMID:11073966 |
| doxorubicin | increases degradation | ISO | RGD:620036 | 6480464 | Doxorubicin results in increased degradation of EP300 protein | CTD | PMID:11073966 |
| doxorubicin | decreases expression | ISO | RGD:620036 | 6480464 | Doxorubicin results in decreased expression of EP300 protein | CTD | PMID:11073966 PMID:15767673 |
| doxorubicin | decreases response to substance | EXP | | 6480464 | EP300 protein results in decreased susceptibility to Doxorubicin | CTD | PMID:14975762 |
| doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of EP300 protein | CTD | PMID:14975762 |
| doxorubicin | multiple interactions | ISO | RGD:620036 | 6480464 | [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein; more ... | CTD | PMID:15767673 |
| doxorubicin | decreases expression | ISO | RGD:1348463 | 6480464 | Doxorubicin results in decreased expression of EP300 protein | CTD | PMID:17498666 PMID:10344722 |
| ellagic acid | increases expression | ISO | RGD:1348463 | 6480464 | Ellagic Acid results in increased expression of EP300 mRNA | CTD | PMID:12002526 |
| etoposide | multiple interactions | ISO | RGD:1348463 | 6480464 | [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; more ... | CTD | PMID:19047049 |
| hyaluronic acid | multiple interactions | ISO | RGD:1348463 | 6480464 | [Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein; more ... | CTD | PMID:19047049 |
| kojic acid | increases expression | ISO | RGD:1348463 | 6480464 | kojic acid results in increased expression of EP300 mRNA | CTD | PMID:16595896 |
| miconazole | decreases expression | ISO | RGD:620036 | 6480464 | Miconazole results in decreased expression of EP300 mRNA | CTD | PMID:22262564 |
| mono(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1348463 | 6480464 | mono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to EP300 protein] | CTD | PMID:20123618 |
| N-acetyl-L-cysteine | multiple interactions | ISO | RGD:1348463 | 6480464 | Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] | CTD | PMID:19281832 |
| omeprazole | multiple interactions | ISO | RGD:1348463 | 6480464 | Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; more ... | CTD | PMID:21703235 |
| phenylephrine | multiple interactions | ISO | RGD:1348463 | 6480464 | EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA] | CTD | PMID:12724418 |
| phenylephrine | multiple interactions | ISO | RGD:620036 | 6480464 | Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein | CTD | PMID:15006641 |
| phenylephrine | increases expression | ISO | RGD:620036 | 6480464 | Phenylephrine results in increased expression of EP300 mRNA | CTD | PMID:11705990 |
| phenylephrine | multiple interactions | ISO | RGD:620036 | 6480464 | [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein | CTD | PMID:12477714 |
| phenylephrine | multiple interactions | ISO | RGD:620036 | 6480464 | Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; more ... | CTD | PMID:15220332 |
| phenylephrine | increases response to substance | ISO | RGD:620036 | 6480464 | EP300 protein results in increased susceptibility to Phenylephrine | CTD | PMID:12477714 |
| phenylephrine | multiple interactions | ISO | RGD:620036 | 6480464 | EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; more ... | CTD | PMID:11705990 |
| phenylephrine | multiple interactions | ISO | RGD:620036 | 6480464 | EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA] | CTD | PMID:15593114 |
| phlorizin | decreases expression | EXP | | 6480464 | Phlorhizin results in decreased expression of EP300 mRNA | CTD | PMID:22538082 |
| pirinixic acid | multiple interactions | EXP | | 6480464 | pirinixic acid promotes the reaction [PPARA protein binds to EP300 protein] | CTD | PMID:20123618 |
| pirinixic acid | multiple interactions | ISO | RGD:1348463 | 6480464 | pirinixic acid promotes the reaction [PPARA protein binds to EP300 protein] | CTD | PMID:20123618 |
| prostaglandin J2 | decreases activity | ISO | RGD:1348463 | 6480464 | 9-deoxy-delta-9-prostaglandin D2 results in decreased activity of EP300 protein | CTD | PMID:22141352 |
| resveratrol | multiple interactions | ISO | RGD:1348463 | 6480464 | resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]; more ... | CTD | PMID:16928824 |
| resveratrol | multiple interactions | ISO | RGD:1348463 | 6480464 | resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; more ... | CTD | PMID:19047049 |
| resveratrol | increases expression | ISO | RGD:1348463 | 6480464 | resveratrol results in increased expression of EP300 mRNA | CTD | PMID:12569576 PMID:12002526 |
| resveratrol | increases expression | ISO | RGD:1348463 | 6480464 | resveratrol results in increased expression of EP300 mRNA | CTD | PMID:12002526 PMID:12569576 |
| tetrathiomolybdate(2-) | multiple interactions | ISO | RGD:620036 | 6480464 | [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; more ... | CTD | PMID:22276220 |
| trans-resveratrol | multiple interactions | ISO | RGD:1348463 | 6480464 | resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]; more ... | CTD | PMID:16928824 |
| trans-resveratrol | multiple interactions | ISO | RGD:1348463 | 6480464 | resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; more ... | CTD | PMID:19047049 |
| trans-resveratrol | increases expression | ISO | RGD:1348463 | 6480464 | resveratrol results in increased expression of EP300 mRNA | CTD | PMID:12569576 PMID:12002526 |
| trans-resveratrol | increases expression | ISO | RGD:1348463 | 6480464 | resveratrol results in increased expression of EP300 mRNA | CTD | PMID:12002526 PMID:12569576 |
| trichostatin A | affects localization | ISO | RGD:1348463 | 6480464 | trichostatin A affects the localization of EP300 protein | CTD | PMID:15647279 |
| trichostatin A | multiple interactions | ISO | RGD:1348463 | 6480464 | trichostatin A promotes the reaction [[EP300 protein co-treated with EGR1 protein] results in increased expression of PTEN mRNA] | CTD | PMID:17330857 |
| trichostatin A | increases response to substance | ISO | RGD:620036 | 6480464 | EP300 protein results in increased susceptibility to trichostatin A | CTD | PMID:12477714 |
| trichostatin A | multiple interactions | ISO | RGD:1348463 | 6480464 | trichostatin A promotes the reaction [EP300 protein binds to TGFBR2 promoter] | CTD | PMID:15647279 |
| trichostatin A | multiple interactions | ISO | RGD:1348463 | 6480464 | trichostatin A promotes the reaction [EP300 protein binds to APEX1 protein] | CTD | PMID:20856196 |
| ursodeoxycholic acid | multiple interactions | ISO | RGD:1348463 | 6480464 | [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to GR1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; more ... | CTD | PMID:18188457 |
| zinc atom | affects expression | ISO | RGD:1348463 | 6480464 | Zinc affects the expression of EP300 protein | CTD | PMID:16636310 |
| zinc atom | multiple interactions | EXP | | 6480464 | Zinc promotes the reaction [MTF1 protein binds to EP300 protein] | CTD | PMID:18458062 more ... |
| zinc atom | multiple interactions | EXP | | 6480464 | EP300 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]; more ... | CTD | PMID:18458062 |
| zinc atom | multiple interactions | EXP | | 6480464 | chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] | CTD | PMID:18605988 |
| zinc atom | multiple interactions | EXP | | 6480464 | Zinc promotes the reaction [MTF1 protein binds to EP300 protein]; more ... | CTD | PMID:21035574 |
| zinc atom | multiple interactions | EXP | | 6480464 | EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]] | CTD | PMID:21467744 |
| zinc(0) | affects expression | ISO | RGD:1348463 | 6480464 | Zinc affects the expression of EP300 protein | CTD | PMID:16636310 |
| zinc(0) | multiple interactions | EXP | | 6480464 | EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]] | CTD | PMID:21467744 |
| zinc(0) | multiple interactions | EXP | | 6480464 | Zinc promotes the reaction [MTF1 protein binds to EP300 protein]; more ... | CTD | PMID:21035574 |
| zinc(0) | multiple interactions | EXP | | 6480464 | chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] | CTD | PMID:18605988 |
| zinc(0) | multiple interactions | EXP | | 6480464 | EP300 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]; more ... | CTD | PMID:18458062 |
| zinc(0) | multiple interactions | EXP | | 6480464 | Zinc promotes the reaction [MTF1 protein binds to EP300 protein] | CTD | PMID:18458062 more ... |