RGD Reference Report - TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity. - Rat Genome Database

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TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity.

Authors: Li, H  Huang, J  Du, W  Jia, C  Yao, H  Wang, Y 
Citation: Li H, etal., J Neurochem. 2012 Dec;123(6):1010-8. doi: 10.1111/jnc.12045. Epub 2012 Nov 1.
RGD ID: 7247583
Pubmed: PMID:23043486   (View Abstract at PubMed)
DOI: DOI:10.1111/jnc.12045   (Journal Full-text)

Excitotoxicity induced by NMDA receptor-mediated intracellular Ca(2+) ([Ca(2+) ](i)) overload is a major cause of delayed neuronal death in cerebral ischemia. Transient receptor potential canonical (TRPC) 6 protects neurons from ischemic brain damage. However, the mechanisms by which TRPC6 protects neurons are largely unknown. Here, we reported that TRPC6 suppressed the [Ca(2+)](i) elevation induced by NMDA and protected neurons from excitotoxicity. Over-expressing or down-regulating TRPC6 suppressed or aggravated Ca(2+) overload under excitotoxicity, respectively. TRPC6 protected cultured neurons from damage caused by NMDA toxicity or oxygen glucose deprivation (OGD). Moreover, the infarct volume in TRPC6 transgenic (Tg) mice was smaller than that in wild-type (WT) littermates. The TRPC6 Tg mice had better behavior performance and lower mortality than their WT littermates. Thus, TRPC6 inhibited NMDA receptor-triggered neurotoxicity and protected neurons from ischemic brain damage. Increase in TRPC6 activity could be a potential strategy for stroke prevention and therapy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transient cerebral ischemia  ISOTrpc6 (Mus musculus)7247583; 7247583 RGD 
transient cerebral ischemia  IMP 7247583 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Trpc6  (transient receptor potential cation channel, subfamily C, member 6)

Genes (Mus musculus)
Trpc6  (transient receptor potential cation channel, subfamily C, member 6)

Genes (Homo sapiens)
TRPC6  (transient receptor potential cation channel subfamily C member 6)


Additional Information