Adamts4 (ADAM metallopeptidase with thrombospondin type 1 motif 4) - Rat Genome Database

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Gene: Adamts4 (ADAM metallopeptidase with thrombospondin type 1 motif 4) Mus musculus
Analyze
Symbol: Adamts4
Name: ADAM metallopeptidase with thrombospondin type 1 motif 4 (Ensembl:a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4)
RGD ID: 1550099
MGI Page MGI
Description: Enables metalloendopeptidase activity. Acts upstream of or within defense response to bacterium and proteolysis. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 3830423K05; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM-; ADAM-TS 4; ADAM-TS4; ADAMTS-2; ADAMTS-4; ADMP-1; aggrecanase-1; mKIAA0688
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,077,698 - 171,089,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,077,990 - 171,088,206 (+)EnsemblGRCm39 Ensembl
GRCm381171,250,129 - 171,262,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,250,421 - 171,260,637 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,180,553 - 173,190,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,087,097 - 173,096,597 (+)NCBIMGSCv36mm8
Celera1173,706,617 - 173,716,194 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dopamine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
fenoldopam  (ISO)
fluoranthene  (EXP)
genistein  (EXP)
gentamycin  (ISO)
graphene oxide  (EXP)
inulin  (EXP)
L-proline betaine  (ISO)
lead diacetate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sotorasib  (ISO)
T-2 toxin  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
WIN 55212-2  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Cross AK, etal., Brain Res. 2006 May 9;1088(1):19-30. Epub 2006 Apr 21.
2. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. Funck-Brentano T, etal., PLoS One. 2012;7(3):e33543. doi: 10.1371/journal.pone.0033543. Epub 2012 Mar 14.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. Yamanishi Y, etal., J Immunol. 2002 Feb 1;168(3):1405-12.
10. Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, etal., Arthritis Res Ther. 2012 Mar 6;14(2):R51. doi: 10.1186/ar3764.
Additional References at PubMed
PMID:10349636   PMID:10356395   PMID:10464288   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11831030   PMID:12477932   PMID:14610273   PMID:15192113   PMID:15334469  
PMID:15368895   PMID:15489334   PMID:15659705   PMID:15782199   PMID:15800624   PMID:15800625   PMID:16141072   PMID:16141073   PMID:16691565   PMID:17243865   PMID:17255106   PMID:17938173  
PMID:17968948   PMID:18039650   PMID:18267097   PMID:18799693   PMID:19922873   PMID:20018883   PMID:20101710   PMID:20448247   PMID:20466812   PMID:20495570   PMID:20637190   PMID:21041365  
PMID:21267068   PMID:21584905   PMID:21873635   PMID:22183742   PMID:22819337   PMID:23082219   PMID:23233348   PMID:23233679   PMID:23319426   PMID:23658023   PMID:23684986   PMID:24194600  
PMID:25101296   PMID:25349050   PMID:25615642   PMID:25770910   PMID:26809777   PMID:27491335   PMID:28850711   PMID:28955046   PMID:29743679   PMID:29791855   PMID:29926003   PMID:30426203  
PMID:30579834   PMID:31264504   PMID:32469162   PMID:32648916   PMID:32909945   PMID:33116313   PMID:36047655   PMID:36721026   PMID:37188512   PMID:37859693   PMID:38374152   PMID:38461223  


Genomics

Comparative Map Data
Adamts4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,077,698 - 171,089,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,077,990 - 171,088,206 (+)EnsemblGRCm39 Ensembl
GRCm381171,250,129 - 171,262,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,250,421 - 171,260,637 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,180,553 - 173,190,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,087,097 - 173,096,597 (+)NCBIMGSCv36mm8
Celera1173,706,617 - 173,716,194 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.28NCBI
ADAMTS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,184,302 - 161,199,054 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,184,302 - 161,199,054 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,154,092 - 161,168,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,426,162 - 159,435,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 341157,972,611 - 157,981,917NCBI
Celera1134,226,690 - 134,235,997 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,516,482 - 132,525,790 (-)NCBIHuRef
CHM1_11162,555,776 - 162,565,083 (-)NCBICHM1_1
T2T-CHM13v2.01160,321,737 - 160,336,495 (-)NCBIT2T-CHM13v2.0
Adamts4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,203,011 - 86,212,500 (+)NCBIGRCr8
mRatBN7.21383,670,556 - 83,680,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,670,183 - 83,680,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,176,431 - 86,185,920 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,574,636 - 87,584,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,806,145 - 84,815,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,622,996 - 89,632,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,622,632 - 89,634,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,249,862 - 94,259,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,142,442 - 87,151,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,336,962 - 87,339,836 (+)NCBI
Celera1383,301,254 - 83,310,782 (+)NCBICelera
Cytogenetic Map13q24NCBI
Adamts4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,951,155 - 12,958,212 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,950,333 - 12,958,599 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,652,642 - 88,667,740 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,343,086 - 88,352,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,602,140 - 136,611,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,514,247 - 140,523,623 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,514,247 - 140,523,623 (-)Ensemblpanpan1.1panPan2
ADAMTS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,283,555 - 21,292,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,284,330 - 21,292,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,358,398 - 21,367,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,401,386 - 21,410,283 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,402,174 - 21,409,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,289,243 - 21,298,133 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,703,669 - 21,712,554 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,112,816 - 22,121,707 (+)NCBIUU_Cfam_GSD_1.0
Adamts4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,282,484 - 7,291,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903491,139 - 500,443 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903490,718 - 500,443 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,260,461 - 89,269,244 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,260,354 - 89,269,238 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,117,041 - 97,125,927 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,781,184 - 2,791,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,783,855 - 2,792,170 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,829,936 - 1,842,272 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794188,207 - 198,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794187,589 - 196,465 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts4
274 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1599
Count of miRNA genes:358
Interacting mature miRNAs:421
Transcripts:ENSMUST00000006570, ENSMUST00000111314, ENSMUST00000111315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
13452393Ity3b_mimmunity to S. typhimurium 3b (mouse)1156497439172097436Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1302037Nktcn1_mnatural killer T cell numbers 1 (mouse)Not determined1168186243171632257Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
4142065Bmd5b_mbone mineral density 5b (mouse)Not determined168835111171765633Mouse
10412205Bbaa30_mB.burgdorferi-associated arthritis 30 (mouse)Not determined1169038741174456436Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
13207571Tcq11_mtotal cholesterol QTL 11 (mouse)1169137569179647565Mouse
13207587Mwmlpt1_mMorris water maze latency to platform, training, 1 (mouse)1169597438173397435Mouse
13207591Mwmlpa1_mMorris water maze latency to platform, all, 1 (mouse)1169797438173297435Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
38456000Lick2_mlick rate 2, sucralose (mouse)1170397438173397435Mouse
38456001Lick1_mlick rate 1, water (mouse)1170397438173397435Mouse
1302201Alcw1_malcohol withdrawal 1 (mouse)Not determined1170868354171966357Mouse
1301016Szs1_mseizure susceptibility 1 (mouse)Not determined1170878743174456436Mouse
4141878Qrr1_mQTL rich region on chromosome 1 (mouse)Not determined170878743175320066Mouse

Markers in Region
Adamts4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371173,182,715 - 173,182,812UniSTSGRCm37
Celera1173,708,781 - 173,708,878UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS
cM Map192.3UniSTS
UniSTS:234266  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,260,230 - 171,260,430UniSTSGRCm38
MGSCv371173,190,361 - 173,190,561UniSTSGRCm37
Celera1173,716,502 - 173,716,702UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS
Adamts4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,252,584 - 171,252,681UniSTSGRCm38
MGSCv371173,182,715 - 173,182,812UniSTSGRCm37
Celera1173,708,781 - 173,708,878UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000111314   ⟹   ENSMUSP00000106946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1171,079,685 - 171,088,206 (+)Ensembl
GRCm38.p6 Ensembl1171,252,116 - 171,260,637 (+)Ensembl
RefSeq Acc Id: ENSMUST00000111315   ⟹   ENSMUSP00000106947
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1171,077,990 - 171,088,206 (+)Ensembl
GRCm38.p6 Ensembl1171,250,421 - 171,260,637 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219033   ⟹   ENSMUSP00000151387
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1171,077,992 - 171,088,205 (+)Ensembl
GRCm38.p6 Ensembl1171,250,423 - 171,260,636 (+)Ensembl
RefSeq Acc Id: NM_172845   ⟹   NP_766433
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391171,077,698 - 171,089,836 (+)NCBI
GRCm381171,250,129 - 171,262,267 (+)NCBI
MGSCv371173,180,553 - 173,190,053 (+)RGD
Celera1173,706,617 - 173,716,194 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766433   ⟸   NM_172845
- Peptide Label: preproprotein
- UniProtKB: Q8K384 (UniProtKB/Swiss-Prot),   Q8BNJ2 (UniProtKB/Swiss-Prot),   Q3TNX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106946   ⟸   ENSMUST00000111314
RefSeq Acc Id: ENSMUSP00000106947   ⟸   ENSMUST00000111315
RefSeq Acc Id: ENSMUSP00000151387   ⟸   ENSMUST00000219033
Protein Domains
Disintegrin   Peptidase M12B   TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BNJ2-F1-model_v2 AlphaFold Q8BNJ2 1-833 view protein structure

Promoters
RGD ID:6875666
Promoter ID:EPDNEW_M1284
Type:single initiation site
Name:Adamts4_1
Description:Mus musculus a disintegrin-like and metallopeptidase with thrombospondintype 1 motif, 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381171,250,426 - 171,250,486EPDNEW
RGD ID:6817263
Promoter ID:MM_KWN:2837
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_2Hour,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000111315
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361173,179,946 - 173,181,512 (+)MPROMDB
RGD ID:6817262
Promoter ID:MM_KWN:2838
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000111314
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361173,181,836 - 173,182,462 (+)MPROMDB
RGD ID:6846578
Promoter ID:MM_ACW:3186
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ADAMTS4.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361173,186,526 - 173,187,026 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339949 AgrOrtholog
Ensembl Genes ENSMUSG00000006403 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000111314.2 UniProtKB/TrEMBL
  ENSMUST00000111315 ENTREZGENE
  ENSMUST00000111315.9 UniProtKB/Swiss-Prot
  ENSMUST00000219033.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:240913 UniProtKB/Swiss-Prot
MGD MGI:1339949 ENTREZGENE
NCBI Gene 240913 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adamts4 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1REPEAT UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATS4_MOUSE UniProtKB/Swiss-Prot
  E9PV91_MOUSE UniProtKB/TrEMBL
  Q3TNX8 ENTREZGENE, UniProtKB/TrEMBL
  Q3U025_MOUSE UniProtKB/TrEMBL
  Q3U0Z2_MOUSE UniProtKB/TrEMBL
  Q8BNJ2 ENTREZGENE
  Q8K384 ENTREZGENE
  Q8VHK4_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8K384 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Adamts4  ADAM metallopeptidase with thrombospondin type 1 motif 4  Adamts4  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4  Symbol and/or name change 5135510 APPROVED