Ngfr (nerve growth factor receptor (TNFR superfamily, member 16)) - Rat Genome Database

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Gene: Ngfr (nerve growth factor receptor (TNFR superfamily, member 16)) Mus musculus
Analyze
Symbol: Ngfr
Name: nerve growth factor receptor (TNFR superfamily, member 16)
RGD ID: 10983
MGI Page MGI
Description: Enables death receptor activity; nerve growth factor binding activity; and small GTPase binding activity. Involved in several processes, including circadian regulation of gene expression; dorsal aorta development; and intracellular glucose homeostasis. Acts upstream of or within several processes, including hair follicle morphogenesis; nervous system development; and regulation of signal transduction. Located in several cellular components, including cell surface; cell-cell junction; and postsynaptic density. Is active in neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and depressive disorder. Orthologous to human NGFR (nerve growth factor receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LN; LNGFR; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; low-affinity nerve growth factor receptor p75NGFR; low-affinity nerve growth factor receptor p75NGR; NGF receptor; p7; p75; p75 neurotrophin receptor; p75N; p75NGFR; p75NTR; Tnfrs; Tnfrsf16; tumor necrosis factor receptor superfamily member 16
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,459,644 - 95,478,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,459,644 - 95,478,561 (-)EnsemblGRCm39 Ensembl
GRCm381195,568,818 - 95,587,698 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,568,818 - 95,587,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,430,132 - 95,449,012 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,384,908 - 95,403,788 (-)NCBIMGSCv36mm8
Celera11105,207,524 - 105,226,387 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-bromo-2'-deoxyuridine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldrin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
celecoxib  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
clozapine  (EXP,ISO)
cobicistat  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylselenide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (EXP)
ethanol  (EXP,ISO)
fenamidone  (EXP)
fenarimol  (ISO)
fenoprofen  (ISO)
fenvalerate  (EXP,ISO)
fluoxetine  (EXP)
flurbiprofen  (ISO)
flusilazole  (ISO)
folic acid  (EXP)
fonofos  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
Fusarenone X  (EXP)
Geniposide pentaacetate  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Re  (EXP)
glyceollin  (ISO)
haloperidol  (ISO)
hydroxyl  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (EXP)
iron dichloride  (ISO)
ketoconazole  (ISO)
ketoprofen  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
lipoic acid  (EXP)
manganese(II) chloride  (ISO)
masoprocol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
Myrtucommulone A  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naproxen  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
oxaprozin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
propanal  (ISO)
propiconazole  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quetiapine fumarate  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
risperidone  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sulindac sulfone  (ISO)
sumatriptan  (ISO)
tebuconazole  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
titanium dioxide  (EXP)
toluene  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
axon guidance  (IMP)
cell differentiation  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to oxidative stress  (ISO)
central nervous system development  (IMP)
circadian regulation of gene expression  (IMP)
circadian rhythm  (IEP)
detection of temperature stimulus  (IMP)
dorsal aorta development  (IMP)
fibroblast growth factor receptor signaling pathway  (IMP)
fibroblast proliferation  (IMP)
glucose homeostasis  (IMP)
hair follicle development  (IMP)
hair follicle morphogenesis  (IMP)
intracellular glucose homeostasis  (IMP)
intracellular protein transport  (IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (IMP)
negative regulation of hair follicle development  (IMP)
negative regulation of mitochondrial depolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron projection development  (ISO)
nerve development  (IMP)
nervous system development  (IEA)
neuron apoptotic process  (ISO)
odontogenesis of dentin-containing tooth  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IDA)
positive regulation of cellular process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of odontogenesis of dentin-containing tooth  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
presynaptic modulation of chemical synaptic transmission  (IDA,IMP)
regulation of gene expression  (IMP)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of response to biotic stimulus  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
Rho protein signal transduction  (IBA,ISO)
rhythmic process  (IEA)
signal transduction  (IEA)
skeletal muscle cell differentiation  (ISO)
skin development  (IMP)
spermatogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon extension  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon pruning  (IAGP)
abnormal behavior  (IEA)
abnormal blood vessel morphology  (IAGP)
abnormal cholinergic neuron morphology  (IAGP)
abnormal circumvallate papillae morphology  (IAGP)
abnormal digit morphology  (IEA)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal gait  (IAGP)
abnormal gustatory papilla taste bud morphology  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal Kupffer cell morphology  (IAGP)
abnormal L5 dorsal root ganglion morphology  (IAGP)
abnormal molar crown morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal olfactory nerve morphology  (IAGP)
abnormal oral cavity morphology  (IAGP)
abnormal peripheral nervous system regeneration  (IAGP)
abnormal posture  (IAGP)
abnormal proprioceptive neuron morphology  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal sensory capabilities/reflexes/nociception  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal spatial learning  (IAGP)
abnormal superior colliculus morphology  (IAGP)
abnormal tongue epithelium morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal vascular wound healing  (IAGP)
absent hair follicles  (IAGP)
absent muscle spindles  (IAGP)
ataxia  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear hair cell degeneration  (IAGP)
decreased airway responsiveness  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased locomotor activity  (IEA)
decreased motor neuron number  (IAGP)
decreased muscle spindle number  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased Schwann cell number  (IAGP)
decreased sensory neuron number  (IAGP)
decreased thigmotaxis  (IEA)
dilated dorsal aorta  (IAGP)
dystonia  (IAGP)
extremity edema  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
increased circulating phosphate level  (IEA)
increased hepatocyte apoptosis  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased neuron number  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased retina photoreceptor cell number  (IAGP)
increased susceptibility to age-related hearing loss  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
limb grasping  (IAGP)
muscle spasm  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
organ of Corti degeneration  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
sensorineural hearing loss  (IAGP)
small L4 dorsal root ganglion  (IAGP)
tremors  (IEA)
ulcerated autopod  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
2. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Allard S, etal., Neurobiol Aging. 2018 Jul;67:10-20. doi: 10.1016/j.neurobiolaging.2018.03.002. Epub 2018 Mar 9.
3. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
4. Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury--I. Degeneration and plastic response of basal forebrain neurons. Arendt T, etal., Neuroscience. 1995 Apr;65(3):633-45. doi: 10.1016/0306-4522(94)00526-b.
5. Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism. Bai Y, etal., J Biol Chem. 2010 Dec 10;285(50):39392-400. Epub 2010 Oct 13.
6. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. Birkeland ML, etal., Eur J Immunol 1995 Apr;25(4):926-30.
7. Dexamethasone reduces the expression of p75 neurotrophin receptor and apoptosis in contused spinal cord. Brandoli C, etal., Brain Res Mol Brain Res. 2001 Feb 19;87(1):61-70.
8. The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush. Cao X, etal., J Mol Neurosci. 2013 Mar;49(3):531-8. doi: 10.1007/s12031-012-9916-0. Epub 2012 Nov 9.
9. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Chaldakov GN, etal., Arch Physiol Biochem. 2001 Oct;109(4):357-60.
10. Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis. Chaldakov GN, etal., Atherosclerosis. 2001 Nov;159(1):57-66.
11. Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease. Cheng HC, etal., J Negat Results Biomed. 2012 Jan 12;11:5. doi: 10.1186/1477-5751-11-5.
12. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
13. Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer. Dang C, etal., J Gastroenterol Hepatol. 2006 May;21(5):850-8.
14. mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. De Simone R, etal., Neuropathol Appl Neurobiol. 1996 Feb;22(1):54-9.
15. Increased nerve growth factor and its receptors in atopic dermatitis: an immunohistochemical study. Dou YC, etal., Arch Dermatol Res. 2006 Jun;298(1):31-7. Epub 2006 Apr 4.
16. Decreased density of forebrain cholinergic neurons in experimental autoimmune dementia. Dubovik V, etal., Neuroscience. 1993 Sep;56(1):75-82.
17. Transplanting p75-suppressed bone marrow stromal cells promotes functional behavior in a rat model of spinal cord injury. Edalat H, etal., Iran Biomed J. 2013;17(3):140-5.
18. Blockage of the afferent sensitive pathway prevents sympathetic atrophy and hemodynamic alterations in rat portal hypertension. Ezkurdia N, etal., Liver Int. 2012 Sep;32(8):1295-305. doi: 10.1111/j.1478-3231.2012.02762.x. Epub 2012 Jan 31.
19. Inhibition of pan neurotrophin receptor p75 attenuates diesel particulate-induced enhancement of allergic airway responses in C57/B16J mice. Farraj AK, etal., Inhal Toxicol. 2006 Jun;18(7):483-91.
20. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Fombonne J, etal., Ann Neurol. 2009 Mar;65(3):294-303.
21. Decreased cutaneous expression of stem cell factor and of the p75NGF receptor in urticaria. Hermes B, etal., Br J Dermatol. 2003 Mar;148(3):411-7.
22. Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related Peptide expression in a rat model of wrist joint inflammatory pain. Iwakura N, etal., J Hand Surg Am. 2010 Feb;35(2):267-73. Epub 2010 Jan 8.
23. Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma. Kerzel S, etal., Am J Respir Cell Mol Biol. 2003 Feb;28(2):170-8.
24. p75NTR expression in rat urinary bladder sensory neurons and spinal cord with cyclophosphamide-induced cystitis. Klinger MB, etal., J Comp Neurol. 2008 Mar 20;507(3):1379-92.
25. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Knowles JK, etal., Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.
26. Nerve growth factor receptor staining of suction biopsies in the diagnosis of Hirschsprung's disease. Kobayashi H, etal., J Pediatr Surg. 1994 Sep;29(9):1224-7.
27. A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. Kunugi H, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):44-6.
28. Deficient p75 low-affinity neurotrophin receptor expression does alter the composition of cellular infiltrate in experimental autoimmune encephalomyelitis in C57BL/6 mice. Kust B, etal., J Neuroimmunol. 2006 May;174(1-2):92-100. Epub 2006 Mar 7.
29. Multimodal neuroprotection induced by PACAP38 in oxygen-glucose deprivation and middle cerebral artery occlusion stroke models. Lazarovici P, etal., J Mol Neurosci. 2012 Nov;48(3):526-40. Epub 2012 Jun 8.
30. Neuronal modulation of lung injury induced by polymeric hexamethylene diisocyanate in mice. Lee CT, etal., Toxicol Appl Pharmacol. 2007 Oct 1;224(1):19-28. Epub 2007 Jun 27.
31. Recombinant human nerve growth factor (rhNGF-beta) gene transfer promotes regeneration of crush-injured mental nerve in rats. Li BH, etal., Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Mar;113(3):e26-34. doi: 10.1016/j.tripleo.2011.07.002.
32. Light and electron microscopic immunohistochemical observations of p75 nerve growth factor receptor-immunoreactive dermal nerves in prurigo nodularis. Liang Y, etal., Arch Dermatol Res. 1999 Jan;291(1):14-21.
33. Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease. Lindner MD, etal., Arch Neurol. 1993 Oct;50(10):1054-60.
34. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
35. The effect of Anti-NGF receptor (p75 Neurotrophin Receptor) antibodies on nociceptive behavior and activation of spinal microglia in the rat brachial plexus avulsion model. Matsuura Y, etal., Spine (Phila Pa 1976). 2013 Mar 15;38(6):E332-8. doi: 10.1097/BRS.0b013e318285ee20.
36. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
37. MGDs mouse GO annotations MGD data from the GO Consortium
38. MGD IEA MGD IEA
39. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
40. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
41. Nerve growth factor receptor expressing human basal forebrain neurons: pathologic alterations in Alzheimer's and Parkinson's disease. Mufson EJ and Kordower JH, Prog Clin Biol Res. 1989;317:401-14.
42. Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy. Murakawa Y, etal., Diabetes Metab Res Rev. 2002 Nov-Dec;18(6):473-83.
43. Mutation of low affinity nerve growth factor receptor gene is associated with the hypertensive phenotype in spontaneously hypertensive inbred rat strains. Nemoto K, etal., Neurosci Lett. 1996 May 24;210(1):69-72.
44. Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs. Orita S, etal., J Orthop Res. 2010 Dec;28(12):1614-20.
45. Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum. Pal A, etal., Br J Nutr. 2013 Aug;110(4):659-70. doi: 10.1017/S0007114512005569. Epub 2013 Jan 14.
46. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. Park JA, etal., J Neurosci. 2000 Dec 15;20(24):9096-103.
47. Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson's and distinction from Alzheimer disease. Perry EK, etal., Alzheimer Dis Assoc Disord. 1993 Summer;7(2):69-79.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. Differential up-regulation of neurotrophin receptors and functional activity of neurotrophins on peripheral blood eosinophils of patients with allergic rhinitis, atopic dermatitis and nonatopic subjects. Raap U, etal., Clin Exp Allergy. 2008 Sep;38(9):1493-8. Epub 2008 Jul 17.
50. Mouse MP Annotation Import Pipeline RGD automated import pipeline
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. Sachs BD, etal., J Cell Biol. 2007 Jun 18;177(6):1119-32.
53. P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease. Salehi A, etal., Exp Neurol. 2000 Jan;161(1):245-58.
54. A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury. Shi J, etal., Stem Cells. 2013 Nov;31(11):2561-74. doi: 10.1002/stem.1516.
55. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. Shulga A, etal., J Neurosci. 2012 Feb 1;32(5):1757-70. doi: 10.1523/JNEUROSCI.3282-11.2012.
56. The mature/pro nerve growth factor ratio is decreased in the brain of diabetic rats: Analysis by ELISA methods. Soligo M, etal., Brain Res. 2015 Oct 22;1624:455-468. doi: 10.1016/j.brainres.2015.08.005. Epub 2015 Aug 15.
57. Vascular and Neuronal Protection Induced by the Ocular Administration of Nerve Growth Factor in Diabetic-Induced Rat Encephalopathy. Tirassa P, etal., CNS Neurosci Ther. 2013 Mar 26. doi: 10.1111/cns.12085.
58. Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Urrego F, etal., Pediatr Pulmonol. 2009 Nov;44(11):1075-84.
59. Enhanced expression of NGF receptors in multiple sclerosis lesions. Valdo P, etal., J Neuropathol Exp Neurol. 2002 Jan;61(1):91-8.
60. Identification of mammalian noggin and its expression in the adult nervous system. Valenzuela DM, etal., J Neurosci 1995 Sep;15(9):6077-84.
61. Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling. Wang T, etal., Acta Pharmacol Sin. 2010 Jul;31(7):765-74. doi: 10.1038/aps.2010.69. Epub 2010 Jun 28.
62. Effects of engrafted neural stem cells in Alzheimer's disease rats. Xuan AG, etal., Neurosci Lett. 2009 Jan 30;450(2):167-71. doi: 10.1016/j.neulet.2008.12.001. Epub 2008 Dec 6.
63. Effect of tonifying liver and kidney-essence herbs on expression of Nogo-A and p75(NTR) in cerebral ischemic stroke rats model. Yan Y, etal., J Tradit Chin Med. 2012 Dec;32(4):664-8.
64. Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat. Yi JS, etal., Neurosci Lett. 2003 Aug 21;347(2):126-30.
65. Up-regulation of p75 neurotrophin receptor (p75NTR) is associated with apoptosis in chronic pancreatitis. Zhu Z, etal., Dig Dis Sci. 2003 Apr;48(4):717-25.
66. Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease. Zuccato C, etal., Brain Pathol. 2008 Apr;18(2):225-38. Epub 2007 Dec 17.
Additional References at PubMed
PMID:571871   PMID:1317267   PMID:1327010   PMID:1450512   PMID:1628813   PMID:1643309   PMID:1686097   PMID:2567264   PMID:2852071   PMID:7546735   PMID:7556925   PMID:7559764  
PMID:7588260   PMID:7600951   PMID:7601910   PMID:7605630   PMID:7751914   PMID:7769664   PMID:7835084   PMID:7903957   PMID:7907978   PMID:7958874   PMID:7958926   PMID:8050673  
PMID:8128229   PMID:8179899   PMID:8306895   PMID:8344468   PMID:8398147   PMID:8637595   PMID:8657306   PMID:8662216   PMID:8854889   PMID:8955272   PMID:8982156   PMID:8986815  
PMID:9042565   PMID:9054500   PMID:9119405   PMID:9151756   PMID:9169087   PMID:9214629   PMID:9267038   PMID:9268129   PMID:9273702   PMID:9315882   PMID:9326226   PMID:9331334  
PMID:9338783   PMID:9342050   PMID:9368064   PMID:9410912   PMID:9454638   PMID:9469614   PMID:9472042   PMID:9514521   PMID:9590438   PMID:9637684   PMID:9640332   PMID:9728914  
PMID:9758704   PMID:9806826   PMID:9835221   PMID:9857182   PMID:9870956   PMID:9886021   PMID:9895316   PMID:10021336   PMID:10188952   PMID:10191100   PMID:10213453   PMID:10215625  
PMID:10215920   PMID:10234043   PMID:10349636   PMID:10357931   PMID:10377349   PMID:10400245   PMID:10412058   PMID:10480904   PMID:10486571   PMID:10491653   PMID:10505613   PMID:10536054  
PMID:10545116   PMID:10583485   PMID:10588868   PMID:10603041   PMID:10611506   PMID:10615047   PMID:10619458   PMID:10624948   PMID:10625055   PMID:10762318   PMID:10764727   PMID:10794857  
PMID:10835639   PMID:10839371   PMID:10862700   PMID:10886328   PMID:10888742   PMID:10908614   PMID:10972938   PMID:10995552   PMID:11007897   PMID:11023977   PMID:11027230   PMID:11027232  
PMID:11042159   PMID:11042591   PMID:11044623   PMID:11076861   PMID:11077419   PMID:11135002   PMID:11156601   PMID:11156606   PMID:11159348   PMID:11163269   PMID:11217851   PMID:11239407  
PMID:11242111   PMID:11322334   PMID:11357193   PMID:11358448   PMID:11409167   PMID:11463606   PMID:11493560   PMID:11559852   PMID:11641219   PMID:11724766   PMID:11731234   PMID:11731238  
PMID:11745667   PMID:11750124   PMID:11756426   PMID:11771768   PMID:11777929   PMID:11819188   PMID:11830582   PMID:11833656   PMID:11859196   PMID:11872939   PMID:11923404   PMID:11978834  
PMID:12011108   PMID:12019323   PMID:12076089   PMID:12117822   PMID:12160745   PMID:12163480   PMID:12194867   PMID:12196586   PMID:12204258   PMID:12231242   PMID:12242267   PMID:12408842  
PMID:12414813   PMID:12417662   PMID:12422217   PMID:12424382   PMID:12438746   PMID:12453482   PMID:12466206   PMID:12466851   PMID:12477932   PMID:12508309   PMID:12524687   PMID:12561075  
PMID:12573711   PMID:12589782   PMID:12595234   PMID:12620975   PMID:12655507   PMID:12675131   PMID:12680838   PMID:12702649   PMID:12722832   PMID:12787557   PMID:12787561   PMID:12794303  
PMID:12805214   PMID:12819136   PMID:12831858   PMID:12843252   PMID:12860969   PMID:12887413   PMID:12904583   PMID:12935912   PMID:14506941   PMID:14572455   PMID:14593116   PMID:14610273  
PMID:14638693   PMID:14643685   PMID:14648839   PMID:14659802   PMID:14681479   PMID:14724254   PMID:14751775   PMID:14966863   PMID:14975585   PMID:14985432   PMID:15015775   PMID:15056289  
PMID:15065125   PMID:15100092   PMID:15126035   PMID:15128850   PMID:15147324   PMID:15163631   PMID:15217369   PMID:15226823   PMID:15254021   PMID:15260993   PMID:15265642   PMID:15365620  
PMID:15376326   PMID:15448099   PMID:15496460   PMID:15533830   PMID:15543141   PMID:15548576   PMID:15558233   PMID:15572360   PMID:15604101   PMID:15647357   PMID:15653467   PMID:15654845  
PMID:15668238   PMID:15703394   PMID:15714282   PMID:15721744   PMID:15754321   PMID:15759267   PMID:15782199   PMID:15795176   PMID:15836427   PMID:15837121   PMID:15837802   PMID:15843406  
PMID:15846783   PMID:15857712   PMID:15866043   PMID:15878242   PMID:15883381   PMID:15966860   PMID:16000635   PMID:16006137   PMID:16009967   PMID:16020529   PMID:16025106   PMID:16049186  
PMID:16116448   PMID:16133146   PMID:16141072   PMID:16141073   PMID:16142215   PMID:16183868   PMID:16193510   PMID:16251447   PMID:16281908   PMID:16319111   PMID:16343477   PMID:16356734  
PMID:16402023   PMID:16460673   PMID:16488412   PMID:16498402   PMID:16539652   PMID:16555252   PMID:16564506   PMID:16602821   PMID:16630834   PMID:16723502   PMID:16762005   PMID:16782087  
PMID:16843677   PMID:16855103   PMID:16887237   PMID:17024414   PMID:17042795   PMID:17083122   PMID:17103416   PMID:17116257   PMID:17117437   PMID:17161916   PMID:17222401   PMID:17241776  
PMID:17278136   PMID:17287525   PMID:17324478   PMID:17360691   PMID:17362911   PMID:17363568   PMID:17376811   PMID:17395831   PMID:17470639   PMID:17493809   PMID:17507395   PMID:17507568  
PMID:17537790   PMID:17600367   PMID:17601531   PMID:17604725   PMID:17610817   PMID:17634195   PMID:17706365   PMID:17716721   PMID:17720696   PMID:17904861   PMID:17916431   PMID:17928338  
PMID:17934455   PMID:17951031   PMID:17964555   PMID:18006062   PMID:18006858   PMID:18024075   PMID:18032650   PMID:18032673   PMID:18049479   PMID:18055214   PMID:18087045   PMID:18094025  
PMID:18162309   PMID:18165280   PMID:18182498   PMID:18194151   PMID:18196575   PMID:18262512   PMID:18272785   PMID:18287559   PMID:18299190   PMID:18322085   PMID:18323418   PMID:18349525  
PMID:18356247   PMID:18367596   PMID:18371392   PMID:18373618   PMID:18374455   PMID:18382462   PMID:18395091   PMID:18397758   PMID:18400893   PMID:18417704   PMID:18430612   PMID:18460603  
PMID:18498735   PMID:18515089   PMID:18570250   PMID:18579736   PMID:18584774   PMID:18586242   PMID:18592162   PMID:18602709   PMID:18663291   PMID:18674600   PMID:18689502   PMID:18709654  
PMID:18717734   PMID:18772898   PMID:18786358   PMID:18799693   PMID:18832397   PMID:18957218   PMID:18988857   PMID:19026664   PMID:19046947   PMID:19072833   PMID:19114089   PMID:19131967  
PMID:19146958   PMID:19193386   PMID:19210757   PMID:19235715   PMID:19272526   PMID:19291307   PMID:19295126   PMID:19325129   PMID:19339612   PMID:19357131   PMID:19360854   PMID:19361496  
PMID:19376199   PMID:19386662   PMID:19389705   PMID:19403658   PMID:19403809   PMID:19407813   PMID:19416837   PMID:19459208   PMID:19508690   PMID:19540218   PMID:19553472   PMID:19572151  
PMID:19633172   PMID:19641107   PMID:19700621   PMID:19710315   PMID:19720059   PMID:19755105   PMID:19812317   PMID:19824062   PMID:20047901   PMID:20063299   PMID:20093372   PMID:20111592  
PMID:20133718   PMID:20152827   PMID:20171203   PMID:20186345   PMID:20190098   PMID:20219632   PMID:20348920   PMID:20368433   PMID:20387078   PMID:20421303   PMID:20460154   PMID:20466052  
PMID:20530577   PMID:20566851   PMID:20584617   PMID:20626560   PMID:20692240   PMID:20696380   PMID:20798032   PMID:20805985   PMID:20844138   PMID:20875398   PMID:20881139   PMID:20955473  
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PMID:23260665   PMID:23274689   PMID:23283078   PMID:23307658   PMID:23319656   PMID:23322532   PMID:23350698   PMID:23351706   PMID:23386589   PMID:23393595   PMID:23410787   PMID:23413832  
PMID:23429478   PMID:23471969   PMID:23559013   PMID:23616554   PMID:23633509   PMID:23642664   PMID:23643381   PMID:23686616   PMID:23761891   PMID:23769981   PMID:23785138   PMID:23806960  
PMID:23821580   PMID:23826407   PMID:23838122   PMID:23862023   PMID:23918145   PMID:23946445   PMID:23959707   PMID:24013014   PMID:24069373   PMID:24080509   PMID:24141719   PMID:24145799  
PMID:24170322   PMID:24173031   PMID:24190996   PMID:24194600   PMID:24224958   PMID:24270184   PMID:24341977   PMID:24357327   PMID:24391519   PMID:24409113   PMID:24409333   PMID:24465223  
PMID:24475283   PMID:24573298   PMID:24582971   PMID:24599786   PMID:24608438   PMID:24685135   PMID:24714156   PMID:24718611   PMID:24908487   PMID:24925912   PMID:24939843   PMID:24948604  
PMID:24952961   PMID:24961238   PMID:25057208   PMID:25079316   PMID:25093680   PMID:25093893   PMID:25131634   PMID:25138596   PMID:25165859   PMID:25180603   PMID:25253694   PMID:25253850  
PMID:25358791   PMID:25359972   PMID:25363691   PMID:25398052   PMID:25433207   PMID:25443284   PMID:25452572   PMID:25535338   PMID:25624266   PMID:25662808   PMID:25720379   PMID:25794678  
PMID:25860837   PMID:25879397   PMID:25898755   PMID:25915623   PMID:25922531   PMID:26015580   PMID:26023097   PMID:26066836   PMID:26073142   PMID:26092122   PMID:26120963   PMID:26134656  
PMID:26160903   PMID:26209882   PMID:26212662   PMID:26268439   PMID:26335717   PMID:26367446   PMID:26387953   PMID:26454009   PMID:26640617   PMID:26663679   PMID:26700963   PMID:26705735  
PMID:26748707   PMID:26758845   PMID:26806701   PMID:26812033   PMID:26818521   PMID:26857994   PMID:26947127   PMID:26967474   PMID:26984409   PMID:26987954   PMID:26988119   PMID:27041467  
PMID:27122033   PMID:27131881   PMID:27166169   PMID:27194337   PMID:27313517   PMID:27348017   PMID:27434667   PMID:27498053   PMID:27559308   PMID:27626380   PMID:27668656   PMID:27683113  
PMID:27746130   PMID:27775873   PMID:27905407   PMID:27917898   PMID:27966429   PMID:28127619   PMID:28192800   PMID:28266720   PMID:28371069   PMID:28407732   PMID:28522736   PMID:28567989  
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PMID:30242146   PMID:30337376   PMID:30348676   PMID:30374941   PMID:30472119   PMID:30524266   PMID:30597659   PMID:30936240   PMID:31073629   PMID:31085607   PMID:31108130   PMID:31171666  
PMID:31191256   PMID:31227770   PMID:31275178   PMID:31276493   PMID:31296846   PMID:31422108   PMID:31488566   PMID:31509576   PMID:31514753   PMID:31515449   PMID:31569049   PMID:31570588  
PMID:31582529   PMID:31588228   PMID:31628183   PMID:31663646   PMID:31843520   PMID:31922317   PMID:31995032   PMID:31996124   PMID:31996225   PMID:32004684   PMID:32215984   PMID:32258033  
PMID:32492250   PMID:32493127   PMID:32541002   PMID:32585763   PMID:32634398   PMID:32658363   PMID:32683751   PMID:32717404   PMID:32770070   PMID:32988586   PMID:33194004   PMID:33335119  
PMID:33340715   PMID:33448137   PMID:33592642   PMID:33604392   PMID:33742683   PMID:33800240   PMID:33879805   PMID:34175311   PMID:34321999   PMID:34338282   PMID:34425092   PMID:34507952  
PMID:34550167   PMID:34678261   PMID:35064700   PMID:35075189   PMID:35283743   PMID:35299237   PMID:35302859   PMID:35315772   PMID:35372344   PMID:35462405   PMID:35469972   PMID:35485233  
PMID:36040414   PMID:36210210   PMID:36213234   PMID:36302841   PMID:36379282   PMID:36672232   PMID:36730190   PMID:36768190   PMID:37120061   PMID:37143894   PMID:37213691   PMID:37279265  
PMID:37401900   PMID:37460457   PMID:37558465   PMID:37590085   PMID:37639482   PMID:37647896   PMID:37647897   PMID:37900943   PMID:38025269   PMID:38029807   PMID:38176461   PMID:38307025  
PMID:38351062   PMID:38424240  


Genomics

Comparative Map Data
Ngfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,459,644 - 95,478,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,459,644 - 95,478,561 (-)EnsemblGRCm39 Ensembl
GRCm381195,568,818 - 95,587,698 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,568,818 - 95,587,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,430,132 - 95,449,012 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,384,908 - 95,403,788 (-)NCBIMGSCv36mm8
Celera11105,207,524 - 105,226,387 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
NGFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,495,293 - 49,515,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,495,293 - 49,515,008 (+)EnsemblGRCh38hg38GRCh38
GRCh371747,572,655 - 47,592,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,927,666 - 44,947,360 (+)NCBINCBI36Build 36hg18NCBI36
Build 341744,927,665 - 44,947,360NCBI
Celera1744,027,660 - 44,047,391 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1742,937,638 - 42,957,366 (+)NCBIHuRef
CHM1_11747,637,800 - 47,657,550 (+)NCBICHM1_1
T2T-CHM13v2.01750,358,300 - 50,378,028 (+)NCBIT2T-CHM13v2.0
Ngfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,012,077 - 81,030,305 (-)NCBIGRCr8
mRatBN7.21080,515,287 - 80,533,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,515,299 - 80,533,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,464,096 - 85,482,268 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,962,134 - 84,980,305 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,354,313 - 80,372,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,389,828 - 83,408,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,389,847 - 83,408,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,198,396 - 83,216,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,262,804 - 84,281,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,277,173 - 84,295,376 (-)NCBI
Celera1079,287,338 - 79,305,497 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ngfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,030,252 - 12,047,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,030,303 - 12,047,305 (-)NCBIChiLan1.0ChiLan1.0
NGFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,652,673 - 15,672,433 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,618,638 - 17,638,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,089,600 - 8,109,361 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,075,301 - 8,094,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,075,316 - 8,094,966 (-)Ensemblpanpan1.1panPan2
NGFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,598,468 - 25,621,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,601,074 - 25,623,274 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,057,204 - 25,079,762 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,393,929 - 26,416,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,396,704 - 26,416,363 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,161,801 - 25,184,255 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,420,950 - 25,443,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,550,245 - 25,572,703 (+)NCBIUU_Cfam_GSD_1.0
Ngfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,017,882 - 25,037,009 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,035,769 - 12,057,263 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,038,500 - 12,057,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,699,427 - 25,720,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,699,410 - 25,720,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,702,140 - 25,722,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,894,000 - 69,914,209 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,894,139 - 69,912,189 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,998,497 - 41,018,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ngfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,623,700 - 5,639,655 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,623,686 - 5,639,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ngfr
539 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:741
Count of miRNA genes:459
Interacting mature miRNAs:532
Transcripts:ENSMUST00000000122
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118869958899081597Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
13524529Bodwtq10_mbody wweight QTL 10 (mouse)119067951297699512Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
1300847Par1_mpulmonary adenoma resistance 1 (mouse)Not determined119406377996167421Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141086Mvwf_mmodifier of von Willebrand factor (mouse)Not determined9545964496176602Mouse

Markers in Region
UniSTS:236705  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,570,386 - 95,570,486UniSTSGRCm38
MGSCv371195,431,700 - 95,431,800UniSTSGRCm37
Celera11105,209,092 - 105,209,192UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.6UniSTS
Ngfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371195,435,543 - 95,435,640UniSTSGRCm37
MGSCv371195,430,482 - 95,430,631UniSTSGRCm37
MGSCv371195,432,262 - 95,432,382UniSTSGRCm37
MGSCv371195,430,723 - 95,432,195UniSTSGRCm37
Celera11105,209,654 - 105,209,774UniSTS
Celera11105,208,115 - 105,209,587UniSTS
Celera11105,212,918 - 105,213,015UniSTS
Celera11105,207,874 - 105,208,023UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.6UniSTS
cM Map1155.6UniSTS
cM Map1155.6UniSTS
cM Map1155.6UniSTS
D10Hmgc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,569,723 - 95,569,923UniSTSGRCm38
MGSCv371195,431,037 - 95,431,237UniSTSGRCm37
Celera11105,208,429 - 105,208,629UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.6UniSTS
Ngfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,570,948 - 95,571,068UniSTSGRCm38
MGSCv371195,432,262 - 95,432,382UniSTSGRCm37
Celera11105,209,654 - 105,209,774UniSTS
Cytogenetic Map11DUniSTS
Ngfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,574,229 - 95,574,326UniSTSGRCm38
MGSCv371195,435,543 - 95,435,640UniSTSGRCm37
Celera11105,212,918 - 105,213,015UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.6UniSTS
Ngfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,569,409 - 95,570,881UniSTSGRCm38
MGSCv371195,430,723 - 95,432,195UniSTSGRCm37
Celera11105,208,115 - 105,209,587UniSTS
Cytogenetic Map11DUniSTS
cM Map1155.6UniSTS
Ngfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1155.6UniSTS
Ngfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381195,569,168 - 95,569,317UniSTSGRCm38
MGSCv371195,430,482 - 95,430,631UniSTSGRCm37
Celera11105,207,874 - 105,208,023UniSTS
Cytogenetic Map11DUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000122   ⟹   ENSMUSP00000000122
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1195,459,644 - 95,478,561 (-)Ensembl
GRCm38.p6 Ensembl1195,568,818 - 95,587,735 (-)Ensembl
RefSeq Acc Id: NM_033217   ⟹   NP_150086
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391195,459,644 - 95,478,524 (-)NCBI
GRCm381195,568,818 - 95,587,698 (-)ENTREZGENE
MGSCv371195,430,132 - 95,449,012 (-)RGD
Celera11105,207,524 - 105,226,387 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_150086   ⟸   NM_033217
- Peptide Label: precursor
- UniProtKB: Q9Z0W1 (UniProtKB/Swiss-Prot),   Q8CFT3 (UniProtKB/TrEMBL),   Q8BYY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000122   ⟸   ENSMUST00000000122
Protein Domains
Death   TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0W1-F1-model_v2 AlphaFold Q9Z0W1 1-427 view protein structure

Promoters
RGD ID:6821421
Promoter ID:MM_KWN:9342
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Spleen
Transcripts:OTTMUST00000003289
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361195,448,621 - 95,449,121 (-)MPROMDB
RGD ID:8676276
Promoter ID:EPDNEW_M16169
Type:initiation region
Name:Ngfr_1
Description:Mus musculus nerve growth factor receptor (TNFR superfamily,member 16) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381195,587,698 - 95,587,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97323 AgrOrtholog
Ensembl Genes ENSMUSG00000000120 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000122 ENTREZGENE
  ENSMUST00000000122.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR16_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF16_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18053 UniProtKB/Swiss-Prot
MGD MGI:97323 ENTREZGENE
NCBI Gene 18053 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_16_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ngfr PhenoGen
PRINTS TNFACTORR16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q8BYY1 ENTREZGENE, UniProtKB/TrEMBL
  Q8CFT3 ENTREZGENE
  Q9Z0W1 ENTREZGENE
  S5MVZ3_MOUSE UniProtKB/TrEMBL
  TNR16_MOUSE UniProtKB/Swiss-Prot
  W8QQI5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8CFT3 UniProtKB/Swiss-Prot