RGD Reference Report - PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus. - Rat Genome Database

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PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus.

Authors: Zhu, J  Shen, W  Gao, L  Gu, H  Shen, S  Wang, Y  Wu, H  Guo, J 
Citation: Zhu J, etal., BMC Neurosci. 2013 Jan 2;14:1. doi: 10.1186/1471-2202-14-1.
RGD ID: 7775014
Pubmed: PMID:23280045   (View Abstract at PubMed)
PMCID: PMC3583678   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2202-14-1   (Journal Full-text)

BACKGROUND: The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases. RESULT: Mitogen-activated protein kinase phosphatase 7 (MKP-7) was upregulated significantly at 4 h of reperfusion postischemia in rat hippocampi. By administration of cycloheximide or siRNA against mitogen-activated protein kinase phosphatase 7 (MKP-7) in a rat model of ischemia/reperfusion, an obvious enhancement of JNK activity was observed in 4 h of reperfusion following ischemia, suggesting MKP-7 was involved in JNK inactivation after ischemia. The subcellular localization of MKP-7 altered after ischemia, and the inhibition of MKP-7 nuclear export by Leptomycin B up-regulated JNK activity. Although PI3K/Akt inhibition could block downregulation of JNK activity through SEK1 and MKK-7 activation, PI3K/Akt activity was not associated with the regulation of JNK by MKP-7. CONCLUSIONS: MKP-7, independently of PI3K/Akt pathway, played a key role in downregulation of JNK activity after ischemia in the rat hippocampus, and the export of MKP-7 from the nucleus was involved in downregulation of cytoplasmic JNK activity in response to ischemic stimuli.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DUSP16Humantransient cerebral ischemia  ISODusp16 (Rattus norvegicus)protein:increased expression more ...RGD 
Dusp16Rattransient cerebral ischemia  IEP protein:increased expression more ...RGD 
Dusp16Mousetransient cerebral ischemia  ISODusp16 (Rattus norvegicus)protein:increased expression more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dusp16  (dual specificity phosphatase 16)

Genes (Mus musculus)
Dusp16  (dual specificity phosphatase 16)

Genes (Homo sapiens)
DUSP16  (dual specificity phosphatase 16)


Additional Information