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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Pentoxifylline
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Accession:CHEBI:7986 term browser browse the term
Definition:An oxopurine that has formula C13H18N4O3.
Synonyms:related_synonym: Formula=C13H18N4O3;   InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3;   InChIKey=BYPFEZZEUUWMEJ-UHFFFAOYSA-N;   SMILES=CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O;   azupentat;   dimethyloxohexylxanthine;   oxpentifylline;   pentoxifyllin
 xref: CAS:6493-05-6;   Drug_Central:2099;   HMDB:HMDB0014944;   KEGG:C07424;   KEGG:D00501;   LINCS:LSM-3285
 xref_mesh: MESH:D010431
 xref: PDBeChem:PNX


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Pentoxifylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
multiple interactions		 EXP Pentoxifylline results in decreased expression of ABCB1 protein
[Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCB1 protein		 CTD PMID:33775688 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions EXP [Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCC1 protein CTD PMID:33775688 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) decreases activity ISO Pentoxifylline results in decreased activity of ACHE protein CTD PMID:11981227 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 ISO
EXP		 Pentoxifylline results in decreased expression of ACTA2 protein
Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]		 CTD PMID:14996430 PMID:18207697 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
decreases expression		 EXP [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein
Pentoxifylline results in decreased expression of BCL2L1 mRNA; Pentoxifylline results in decreased expression of BCL2L1 protein		 CTD PMID:18851957 PMID:20804743 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of BID protein] CTD PMID:20804743 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein CTD PMID:20804743 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions EXP [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC3 protein CTD PMID:20804743 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO [Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased activity of BRAF protein CTD PMID:21693435 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929 		JBrowse link
G CASP1 caspase 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of CASP1 protein] CTD PMID:36690085 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 Pentoxifylline inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
[Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of CASP3 protein
Pentoxifylline results in increased activity of CASP3 protein		 CTD PMID:16317704 PMID:18851957 PMID:33775688 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein] CTD PMID:20804743 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP [Pentoxifylline co-treated with TNFSF10 protein] results in increased activity of CASP9 protein CTD PMID:20804743 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]		 CTD PMID:16703270 PMID:20194575 PMID:23695977 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion
decreases expression		 ISO
EXP		 Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Pentoxifylline results in decreased secretion of CCL2 protein
Pentoxifylline results in decreased expression of CCL2 mRNA		 CTD PMID:14993492 PMID:18617301 PMID:19921414 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 decreases expression ISO Pentoxifylline results in decreased expression of CCL5 mRNA CTD PMID:14993492 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCN2 cellular communication network factor 2 decreases expression ISO Pentoxifylline results in decreased expression of CCN2 mRNA CTD PMID:11788567 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CCNA2 cyclin A2 multiple interactions EXP Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]] CTD PMID:8463339 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]] CTD PMID:8463339 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CD69 CD69 molecule decreases expression ISO Pentoxifylline results in decreased expression of CD69 protein CTD PMID:25433234 NCBI chr12:9,752,486...9,760,901
Ensembl chr12:9,752,486...9,760,901 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]] CTD PMID:8463339 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions EXP Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]] CTD PMID:8463339 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions ISO [Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein CTD PMID:21693435 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions
decreases expression		 EXP [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein
Pentoxifylline results in decreased expression of CFLAR protein		 CTD PMID:18851957 PMID:20804743 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CKM creatine kinase, M-type multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased secretion of CKM protein] CTD PMID:36690085 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
decreases expression		 ISO
EXP		 Pentoxifylline inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]
Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
Pentoxifylline results in decreased expression of COL1A1 mRNA		 CTD PMID:7617123 PMID:11788567 PMID:12419648 PMID:14993492 PMID:17952619 More... NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression ISO Pentoxifylline results in decreased expression of COL3A1 protein CTD PMID:11788567 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CRP C-reactive protein decreases expression EXP Pentoxifylline results in decreased expression of CRP protein CTD PMID:14970111 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein] CTD PMID:17698507 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP Pentoxifylline decreases expression of CXCL8 mRNA in peripheral blood mononuclear cells RGD PMID:16764700 RGD:39939052 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYCS cytochrome c, somatic increases secretion
multiple interactions		 EXP Pentoxifylline results in increased secretion of CYCS protein
Pentoxifylline promotes the reaction [TNFSF10 protein results in increased secretion of CYCS protein]		 CTD PMID:18851957 PMID:20804743 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP Pentoxifylline results in decreased activity of CYP1A2 protein CTD PMID:11465391 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G FAS Fas cell surface death receptor increases expression
decreases expression		 EXP Pentoxifylline results in increased expression of FAS mRNA; Pentoxifylline results in increased expression of FAS protein
Pentoxifylline results in decreased expression of FAS protein		 CTD PMID:14970111 PMID:18851957 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Pentoxifylline results in increased expression of FOS mRNA CTD PMID:18851957 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression EXP Pentoxifylline results in increased expression of GADD45A mRNA CTD PMID:18851957 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GSDMD gasdermin D multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein] CTD PMID:36690085 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of HAVCR1 protein] CTD PMID:32777238 NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396 		JBrowse link
G HMOX1 heme oxygenase 1 decreases expression EXP Pentoxifylline results in decreased expression of HMOX1 protein CTD PMID:22461696 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression ISO Pentoxifylline results in decreased expression of ICAM1 mRNA CTD PMID:14993492 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Pentoxifylline promotes the reaction [Zymosan results in increased expression of IL10 protein] CTD PMID:11301049 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Pentoxifylline promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of IL1B protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]		 CTD PMID:15711975 PMID:16133968 PMID:17167242 PMID:17698507 PMID:23695977 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha multiple interactions
decreases expression
decreases secretion		 EXP
ISO		 N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [Pentoxifylline results in decreased expression of IL2RA protein]
Pentoxifylline results in decreased secretion of IL2RA protein
Pentoxifylline results in decreased expression of IL2RA mRNA; Pentoxifylline results in decreased expression of IL2RA protein		 CTD PMID:1709825 PMID:25433234 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370 		JBrowse link
G IL4 interleukin 4 increases expression ISO Pentoxifylline results in increased expression of IL4 mRNA CTD PMID:7589090 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression		 ISO Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Pentoxifylline results in decreased expression of IL6 mRNA
Acetaldehyde promotes the reaction [Pentoxifylline results in decreased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]		 CTD PMID:12419648 PMID:15711975 PMID:17167242 PMID:17698507 PMID:17952619 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGB2 integrin subunit beta 2 affects expression EXP Pentoxifylline affects the expression of ITGB2 CTD PMID:1976392 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MAP1LC3B protein modified form] CTD PMID:32777238 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 multiple interactions
affects binding		 ISO
EXP		 Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MAP3K7 protein]
Pentoxifylline binds to MAP3K7 protein		 CTD PMID:32777238 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:19697996 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:19697996 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression EXP Pentoxifylline results in increased expression of MAPK8 protein; Pentoxifylline results in increased expression of MAPK8 protein modified form CTD PMID:20804743 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases expression EXP Pentoxifylline results in increased expression of MAPK9 protein; Pentoxifylline results in increased expression of MAPK9 protein modified form CTD PMID:20804743 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member increases expression EXP Pentoxifylline results in increased expression of MCL1 mRNA CTD PMID:18851957 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MIR26B microRNA 26b multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MIR26B mRNA] CTD PMID:32777238 NCBI chr 2:218,402,646...218,402,722
Ensembl chr 2:218,402,646...218,402,722 		JBrowse link
G MIR34A microRNA 34a multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MIR34A mRNA] CTD PMID:32777238 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777 		JBrowse link
G MIRLET7B microRNA let-7b multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MIRLET7B mRNA] CTD PMID:32777238 NCBI chr22:46,113,686...46,113,768
Ensembl chr22:46,113,686...46,113,768 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO Pentoxifylline inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16133968 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MTOR protein] CTD PMID:32777238 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased expression of MYC protein] CTD PMID:36690085 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:17952619 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Pentoxifylline inhibits the reaction [Acetaldehyde results in decreased expression of NFKBIA protein]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] CTD PMID:17952619 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased expression of NLRP3 protein] CTD PMID:36690085 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein] CTD PMID:16133968 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPPB natriuretic peptide B decreases expression EXP Pentoxifylline results in decreased expression of NPPB protein CTD PMID:14970111 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP [Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of PARP1 protein; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
Pentoxifylline results in increased cleavage of PARP1 protein		 CTD PMID:18851957 PMID:20804743 PMID:33775688 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PRF1 perforin 1 decreases secretion EXP Pentoxifylline results in decreased secretion of PRF1 protein CTD PMID:17880773 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
G PSMA1 proteasome 20S subunit alpha 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA1 mRNA] CTD PMID:18801959 NCBI chr11:14,504,876...14,643,662
Ensembl chr11:14,504,874...14,643,635 		JBrowse link
G PSMA3 proteasome 20S subunit alpha 3 multiple interactions ISO Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA] CTD PMID:18801959 NCBI chr14:58,244,843...58,272,004
Ensembl chr14:58,244,843...58,272,012 		JBrowse link
G PSMC6 proteasome 26S subunit, ATPase 6 multiple interactions ISO Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMC6 mRNA] CTD PMID:18801959 NCBI chr14:52,707,200...52,728,590
Ensembl chr14:52,707,178...52,728,590 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Pentoxifylline inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein] CTD PMID:17638016 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RAP1B RAP1B, member of RAS oncogene family multiple interactions EXP
ISO		 [Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate] CTD PMID:21693435 NCBI chr12:68,610,899...68,671,901
Ensembl chr12:68,610,855...68,671,901 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Pentoxifylline inhibits the reaction and results in decreased activity of Ethanol inhibits the reaction and results in decreased activity of RELA protein
[Pentoxifylline co-treated with Doxorubicin] results in decreased phosphorylation of RELA protein
Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]; Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of RELA protein]		 CTD PMID:16317704 PMID:17952619 PMID:32777238 PMID:33775688 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]] CTD PMID:17698507 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SPP1 secreted phosphoprotein 1 decreases expression ISO Pentoxifylline results in decreased expression of SPP1 mRNA CTD PMID:14993492 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression
multiple interactions		 ISO Pentoxifylline results in decreased expression of TGFB1 mRNA
Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]		 CTD PMID:11788567 PMID:32777238 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 multiple interactions
affects binding		 ISO
EXP		 Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFBR1 mRNA]; Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]
Pentoxifylline binds to TGFBR1 protein		 CTD PMID:32777238 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression ISO Pentoxifylline results in increased expression of TIMP1 mRNA CTD PMID:11788567 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased expression of TLR4 protein] CTD PMID:36690085 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
increases expression
decreases secretion		 EXP
ISO		 Pentoxifylline results in decreased expression of TNF mRNA; Pentoxifylline results in decreased expression of TNF protein
Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Glycerol results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[Pentoxifylline results in decreased expression of TNF mRNA] results in decreased susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; Pentoxifylline inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ethanol results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Pentoxifylline inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Pentoxifylline inhibits the reaction [Zymosan results in increased expression of TNF protein]
Pentoxifylline results in increased expression of TNF protein
Pentoxifylline results in decreased secretion of TNF protein		 CTD PMID:1593221 PMID:7589090 PMID:7769305 PMID:8741040 PMID:10773043 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a increases expression EXP Pentoxifylline results in increased expression of TNFRSF10A protein CTD PMID:20804743 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b increases expression EXP Pentoxifylline results in increased expression of TNFRSF10B protein CTD PMID:20804743 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions
increases expression		 EXP [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC3 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [Pentoxifylline co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of BID protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased secretion of CYCS protein]
Pentoxifylline results in increased expression of TNFSF10 mRNA		 CTD PMID:18851957 PMID:20804743 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 decreases expression ISO Pentoxifylline results in decreased expression of VCAM1 mRNA CTD PMID:14720322 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO Pentoxifylline results in decreased expression of VEGFA mRNA CTD PMID:14720322 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:20804743 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      atom 26015
        nonmetal atom 25503
          nitrogen atom 22528
            nitrogen molecular entity 22528
              organonitrogen compound 21922
                organonitrogen heterocyclic compound 20332
                  imidazopyrimidine 8064
                    purines 8063
                      oxopurine 6649
                        Pentoxifylline 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organic heteropolycyclic compound 21317
                                    organic heterobicyclic compound 18560
                                      imidazopyrimidine 8064
                                        purines 8063
                                          oxopurine 6649
                                            Pentoxifylline 84
paths to the root