CDK1 (cyclin-dependent kinase 1) - Rat Genome Database

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Keyword

Gene: CDK1 (cyclin-dependent kinase 1) Homo sapiens

Symbol:

CDK1

Name:

cyclin-dependent kinase 1

Description:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CDC2; CDC28A; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2 homolog a (s. pombe); cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; OTTHUMP00000019659; OTTHUMP00000019660; OTTHUMP00000223862; p34 protein kinase; P34CDC2

Orthologs:

Mus musculus : Cdk1 (cyclin-dependent kinase 1) MGI
Rattus norvegicus : Cdk1 (cyclin-dependent kinase 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	10	62,910,540 - 62,927,054	+	NCBI
Human Genome Assembly HuRef	10	56,527,463 - 56,544,301	+	NCBI
Human Genome Assembly GRCh37	10	62,538,089 - 62,554,610	+	NCBI
Human Genome Assembly Build 36	10	62,205,690 - 62,223,930	+	NCBI
Human Cytogenetic Map	10	q21.1		NCBI
Human Genome Assembly	10	62,209,916 - 62,223,930		NCBI