SPP1 (secreted phosphoprotein 1) - Rat Genome Database

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Keyword

Gene: SPP1 (secreted phosphoprotein 1) Homo sapiens

Symbol:

SPP1

Name:

secreted phosphoprotein 1

Description:

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

BNSP; bone sialoprotein 1; bone sialoprotein I; BSPI; early T-lymphocyte activation 1; ETA-1; MGC110940; nephropontin; OPN; osteopontin; osteopontin-C; osteopontin-D; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; OTTHUMP00000161173; OTTHUMP00000161174; OTTHUMP00000218555; OTTHUMP00000218556; secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein); SPP-1; SPP1/CALPHA1 fusion; urinary stone protein; uropontin

Orthologs:

Mus musculus : Spp1 (secreted phosphoprotein 1) MGI
Rattus norvegicus : Spp1 (secreted phosphoprotein 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	4	88,705,381 - 88,713,139	+	NCBI
Human Genome Assembly HuRef	4	84,643,231 - 84,650,994	+	NCBI
Human Genome Assembly GRCh37	4	88,896,802 - 88,904,563	+	NCBI
Human Genome Assembly Build 36	4	89,115,826 - 89,123,587	+	NCBI
Human Cytogenetic Map	4	q22.1		NCBI
Human Genome Assembly	4	89,253,980 - 89,261,741		NCBI