BW287_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: BW287_H (Body Weight QTL 287 (human)) Homo sapiens

Symbol: BW287_H
Name: Body Weight QTL 287 (human)
RGD ID: 1643515
Trait: Body weight
Measurement Type: BMI
LOD Score: 2.45
P Value: 4.0E-4
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381018,424,110 - 44,424,110RGD_MAPPER_PIPELINEGRCh38
GRCh371026,526,893 - 36,189,680RGDGRCh37
Build 361026,566,899 - 36,229,686RGDNCBI36
Population Stats: obesity study of 93 German nuclear families
JBrowse: View Region in Genome Browser (JBrowse)
Model



ZEB1 is a candidate Gene for BW287_H


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BW287_HHumanobesity  IAGP 1298038 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BW287_HHumanObesity  IAGP 1298038 RGD 

#
Reference Title
Reference Citation
1. Independent confirmation of a major locus for obesity on chromosome 10. Hinney A, etal., J Clin Endocrinol Metab 2000 Aug;85(8):2962-5.
2. Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Kraja AT, etal., Hypertension. 2005 Oct;46(4):751-7. Epub 2005 Sep 19.

Related QTL Description Reference
BW286_H maps to same region RGD:1298038
BW22_H maps to same region RGD:1298038



1 to 20 of 1447 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
732576CACNB2calcium voltage-gated channel auxiliary subunit beta 2101814042418543557Human
329843889LOC130003456ATAC-STARR-seq lymphoblastoid active region 3112101847199418472213Human
151675307CACNB2-AS1CACNB2 antisense RNA 1101851261618539276Human
151670104LOC124902387uncharacterized LOC124902387101853184918534796Human
1344487NSUN6NOP2/Sun RNA methyltransferase 6101854556118659327Human
155770406LOC127817345NANOG hESC enhancer GRCh37_chr10:18841481-18841982101855255218553053Human
329824100LOC130003457ATAC-STARR-seq lymphoblastoid active region 3113101862769818627907Human
329834625LOC130003458ATAC-STARR-seq lymphoblastoid active region 3114101865172718651826Human
329826060LOC130003459ATAC-STARR-seq lymphoblastoid active region 3115101865826018658379Human
329822471LOC130003460ATAC-STARR-seq lymphoblastoid active region 3116101865908018659209Human
1313675ARL5BARF like GTPase 5B101865943118681639Human
329822058LOC130003461ATAC-STARR-seq lymphoblastoid silent region 2184101865952018659599Human
38632225LOC105376440uncharacterized LOC105376440101871029418836543Human
7205112AIFM1P1AIFM1 pseudogene 1101873567518738839Human
155230380LOC126860874BRD4-independent group 4 enhancer GRCh37_chr10:19041189-19042388101875226018753459Human
329329533LOC129390147MPRA-validated peak892 silencer101882225618822456Human
38635685LOC107984180uncharacterized LOC107984180101892913818930701Human
1346421MALRD1MAM and LDL receptor class A domain containing 1101904692719734478Human
7204912UBE2V2P1ubiquitin conjugating enzyme E2 V2 pseudogene 1101905145519052172Human
155774488LOC127817346H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:19382617-19383196101909368819094267Human

1 to 20 of 1447 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match

Flank 1: (D10S197)
Human AssemblyChrPosition (strand)Source
GRCh371026,526,893 - 26,527,063UniSTS
GRCh371026,527,050 - 26,527,138UniSTS
Build 361026,566,899 - 26,567,069RGD
Celera1026,238,651 - 26,238,821RGD
Celera1026,238,808 - 26,238,896UniSTS
Cytogenetic Map10p11.23UniSTS
HuRef1026,186,475 - 26,186,563UniSTS
HuRef1026,186,316 - 26,186,488UniSTS
Marshfield Genetic Map1052.1UniSTS
Marshfield Genetic Map1052.1RGD
Genethon Genetic Map1050.5UniSTS
deCODE Assembly Map1050.04UniSTS
Stanford-G3 RH Map101269.0UniSTS
GeneMap99-GB4 RH Map10163.28UniSTS
Whitehead-RH Map10170.1UniSTS
Whitehead-YAC Contig Map10 UniSTS
NCBI RH Map10419.6UniSTS
GeneMap99-G3 RH Map101269.0UniSTS
Peak: (ZEB1)
Human AssemblyChrPosition (strand)Source
GRCh381031,318,417 - 31,529,804 (+)NCBI
GRCh38.p14 Ensembl1031,318,495 - 31,529,814 (+)Ensembl
GRCh371031,607,346 - 31,818,732 (+)NCBI
Build 361031,648,148 - 31,856,742 (+)NCBI
Build 341031,648,147 - 31,856,740NCBI
Celera1031,373,372 - 31,583,958 (+)NCBI
Cytogenetic Map10p11.22NCBI
HuRef1031,330,231 - 31,538,974 (+)NCBI
CHM1_11031,608,067 - 31,818,701 (+)NCBI
T2T-CHM13v2.01031,348,155 - 31,559,554 (+)NCBI
Flank 2: (D10S1768)
Human AssemblyChrPosition (strand)Source
GRCh371036,189,504 - 36,189,680UniSTS
Build 361036,229,510 - 36,229,686RGD
Celera1035,955,782 - 35,955,958RGD
HuRef1035,909,512 - 35,909,688UniSTS
Marshfield Genetic Map1062.23UniSTS
Marshfield Genetic Map1062.23RGD
Genethon Genetic Map1062.0UniSTS
TNG Radiation Hybrid Map1018849.0UniSTS
deCODE Assembly Map1062.33UniSTS
Whitehead-YAC Contig Map10 UniSTS


1 to 10 of 2481 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597316506GWAS1412580_Hdiastolic blood pressure, systolic blood pressure QTL GWAS1412580 (human)0.000002diastolic blood pressure, systolic blood pressuresystolic blood pressure (CMO:0000004)101995053019950531Human
597291929GWAS1388003_Hbody mass index QTL GWAS1388003 (human)3e-09body mass indexbody mass index (BMI) (CMO:0000105)103462295134622952Human
597316507GWAS1412581_Hdiastolic blood pressure, systolic blood pressure QTL GWAS1412581 (human)4e-09diastolic blood pressure, systolic blood pressuresystolic blood pressure (CMO:0000004)101995056619950567Human
597255064GWAS1351138_Hage at first sexual intercourse measurement QTL GWAS1351138 (human)1e-19age at first sexual intercourse measurement102296392222963928Human
597291928GWAS1388002_Hbody mass index QTL GWAS1388002 (human)2e-09body mass indexbody mass index (BMI) (CMO:0000105)103397472533974726Human
596988823GWAS1108342_Hmemory performance QTL GWAS1108342 (human)0.000006memory performance102288788322887884Human
597615514GWAS1672374_Hprostate specific antigen amount QTL GWAS1672374 (human)3e-18prostate specific antigen amount102311146423111465Human
597263261GWAS1359335_H1-Methylhistidine measurement QTL GWAS1359335 (human)0.0000031-Methylhistidine measurement103389747733897478Human
597615515GWAS1672375_Hprostate specific antigen amount QTL GWAS1672375 (human)2e-25prostate specific antigen amount102780782527807826Human
597615513GWAS1672373_Hprostate specific antigen amount QTL GWAS1672373 (human)4e-18prostate specific antigen amount102203126422031265Human

1 to 10 of 2481 rows


Note Type Note Reference
qtl_map Chromosome 10, 60.64 cM 1298038
qtl_population obesity study of 93 German nuclear families 1298038
qtl_population_details 386 individuals 1298038
qtl_statistics_details two point and multipoint analyses using the maximum likelihood binomial (MLB) statistics as implemented in MLBGH 1298038