MPP7 (membrane palmitoylated protein 7) - Rat Genome Database

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Gene: MPP7 (membrane palmitoylated protein 7) Homo sapiens
Analyze
Symbol: MPP7
Name: membrane palmitoylated protein 7
RGD ID: 1344792
HGNC Page HGNC
Description: Exhibits molecular adaptor activity and protein domain specific binding activity. Involved in bicellular tight junction assembly; positive regulation of protein-containing complex assembly; and protein localization to adherens junction. Localizes to MPP7-DLG1-LIN7 complex; bicellular tight junction; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ32798; MAGUK p55 subfamily member 7; membrane protein, palmitoylated 7; membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); RP11-218D6.5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1028,050,993 - 28,334,486 (-)EnsemblGRCh38hg38GRCh38
GRCh381028,050,993 - 28,303,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371028,339,922 - 28,591,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361028,379,928 - 28,611,073 (-)NCBINCBI36hg18NCBI36
Build 341028,382,995 - 28,611,021NCBI
Celera1028,103,324 - 28,334,425 (-)NCBI
Cytogenetic Map10p12.1NCBI
HuRef1028,057,989 - 28,289,085 (-)NCBIHuRef
CHM1_11028,339,855 - 28,591,938 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:14702039   PMID:14719143   PMID:16385451   PMID:16678097   PMID:17237226   PMID:17332497   PMID:17616219   PMID:19208380   PMID:19216786   PMID:19615732   PMID:20379614   PMID:20702775  
PMID:21116278   PMID:21145499   PMID:22005930   PMID:22171069   PMID:22258158   PMID:22504420   PMID:23251661   PMID:23355945   PMID:23951440   PMID:24038936   PMID:24249740   PMID:24255178  
PMID:24366813   PMID:24877562   PMID:24945404   PMID:25073539   PMID:25468996   PMID:25544563   PMID:26109466   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26638075   PMID:27001270  
PMID:27880917   PMID:28330616   PMID:28514442   PMID:28675297   PMID:29395067   PMID:29568061   PMID:30194290   PMID:30639242   PMID:31527615   PMID:31586073   PMID:31678930   PMID:31772230  
PMID:31822558   PMID:31980649   PMID:32296183   PMID:32457219  


Genomics

Comparative Map Data
MPP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1028,050,993 - 28,334,486 (-)EnsemblGRCh38hg38GRCh38
GRCh381028,050,993 - 28,303,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371028,339,922 - 28,591,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361028,379,928 - 28,611,073 (-)NCBINCBI36hg18NCBI36
Build 341028,382,995 - 28,611,021NCBI
Celera1028,103,324 - 28,334,425 (-)NCBI
Cytogenetic Map10p12.1NCBI
HuRef1028,057,989 - 28,289,085 (-)NCBIHuRef
CHM1_11028,339,855 - 28,591,938 (-)NCBICHM1_1
Mpp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,347,962 - 7,627,017 (-)NCBIGRCm39mm39
GRCm39 Ensembl187,347,959 - 7,626,866 (-)Ensembl
GRCm38187,347,962 - 7,626,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,347,959 - 7,626,866 (-)EnsemblGRCm38mm10GRCm38
MGSCv37187,347,960 - 7,626,861 (-)NCBIGRCm37mm9NCBIm37
MGSCv36187,350,735 - 7,626,861 (-)NCBImm8
Celera187,393,501 - 7,674,355 (-)NCBICelera
Cytogenetic Map18A1NCBI
Mpp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21755,439,939 - 55,706,810 (-)NCBI
Rnor_6.0 Ensembl1760,059,949 - 60,250,352 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01760,057,077 - 60,250,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01761,830,031 - 62,034,038 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41763,992,348 - 64,282,603 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11764,003,180 - 64,293,387 (-)NCBI
Celera1756,783,242 - 56,969,313 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Mpp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554621,938,424 - 2,154,507 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554621,933,364 - 2,154,473 (-)NCBIChiLan1.0ChiLan1.0
MPP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11028,560,675 - 28,812,299 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1028,560,859 - 28,764,212 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01028,202,057 - 28,453,950 (-)NCBIMhudiblu_PPA_v0panPan3
MPP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,793,164 - 18,104,268 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,885,581 - 18,101,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24,773,528 - 4,994,243 (-)NCBI
ROS_Cfam_1.0216,043,130 - 16,356,765 (+)NCBI
UMICH_Zoey_3.1215,482,047 - 15,788,491 (+)NCBI
UNSW_CanFamBas_1.0215,368,847 - 15,676,345 (+)NCBI
UU_Cfam_GSD_1.0215,397,180 - 16,078,932 (+)NCBI
Mpp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093447,821,348 - 8,053,181 (-)NCBI
SpeTri2.0NW_0049366132,371,923 - 2,603,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1039,532,377 - 39,798,356 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11039,532,374 - 39,798,357 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21053,000,189 - 53,222,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPP7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1927,622,837 - 27,875,190 (-)NCBI
ChlSab1.1 Ensembl927,622,672 - 27,827,622 (-)Ensembl
Mpp7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248056,430,817 - 6,636,865 (-)NCBI

Position Markers
D10S588  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,488,767 - 28,488,908UniSTSGRCh37
GRCh371028,488,789 - 28,488,907UniSTSGRCh37
Build 361028,528,795 - 28,528,913RGDNCBI36
Celera1028,252,145 - 28,252,263RGD
Celera1028,252,123 - 28,252,264UniSTS
Cytogenetic Map10p12.1UniSTS
HuRef1028,206,816 - 28,206,934UniSTS
HuRef1028,206,794 - 28,206,935UniSTS
Marshfield Genetic Map1054.23UniSTS
Marshfield Genetic Map1054.23RGD
Genethon Genetic Map1053.4UniSTS
TNG Radiation Hybrid Map1014735.0UniSTS
deCODE Assembly Map1052.23UniSTS
Stanford-G3 RH Map101453.0UniSTS
GeneMap99-GB4 RH Map10174.91UniSTS
Whitehead-RH Map10199.3UniSTS
Whitehead-YAC Contig Map10 UniSTS
GeneMap99-G3 RH Map101453.0UniSTS
STS-H97962  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,340,109 - 28,340,294UniSTSGRCh37
Build 361028,380,115 - 28,380,300RGDNCBI36
Celera1028,103,511 - 28,103,696RGD
Cytogenetic Map10p12.1UniSTS
HuRef1028,058,176 - 28,058,361UniSTS
GeneMap99-GB4 RH Map10173.0UniSTS
SHGC-81652  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,369,870 - 28,370,142UniSTSGRCh37
Build 361028,409,876 - 28,410,148RGDNCBI36
Celera1028,133,272 - 28,133,544RGD
Cytogenetic Map10p12.1UniSTS
HuRef1028,087,943 - 28,088,215UniSTS
TNG Radiation Hybrid Map1014685.0UniSTS
SHGC-81705  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,562,332 - 28,562,631UniSTSGRCh37
Build 361028,602,338 - 28,602,637RGDNCBI36
Celera1028,325,690 - 28,325,989RGD
Cytogenetic Map10p12.1UniSTS
HuRef1028,280,350 - 28,280,649UniSTS
TNG Radiation Hybrid Map1014804.0UniSTS
RH122845  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,528,967 - 28,529,239UniSTSGRCh37
Build 361028,568,973 - 28,569,245RGDNCBI36
Celera1028,292,326 - 28,292,598RGD
Cytogenetic Map10p12.1UniSTS
HuRef1028,246,995 - 28,247,267UniSTS
TNG Radiation Hybrid Map1014774.0UniSTS
RH118971  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,550,080 - 28,550,375UniSTSGRCh37
Build 361028,590,086 - 28,590,381RGDNCBI36
Celera1028,313,438 - 28,313,733RGD
Cytogenetic Map10p12.1UniSTS
HuRef1028,268,107 - 28,268,402UniSTS
TNG Radiation Hybrid Map1014793.0UniSTS
SHGC-33447  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,341,063 - 28,341,163UniSTSGRCh37
Build 361028,381,069 - 28,381,169RGDNCBI36
Celera1028,104,465 - 28,104,565RGD
Cytogenetic Map10p12.1UniSTS
HuRef1028,059,130 - 28,059,230UniSTS
Stanford-G3 RH Map101427.0UniSTS
GeneMap99-GB4 RH Map10192.39UniSTS
Whitehead-RH Map10200.4UniSTS
NCBI RH Map10462.5UniSTS
GeneMap99-G3 RH Map101427.0UniSTS
MPP7  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371028,409,192 - 28,409,308UniSTSGRCh37
Celera1028,172,596 - 28,172,712UniSTS
STS-H72934  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10p12.1UniSTS
HuRef1028,188,936 - 28,189,197UniSTS
GeneMap99-GB4 RH Map10173.31UniSTS
D10S588  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10p12.1UniSTS
TNG Radiation Hybrid Map1014735.0UniSTS
Stanford-G3 RH Map101453.0UniSTS
GeneMap99-G3 RH Map101453.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4737
Count of miRNA genes:948
Interacting mature miRNAs:1106
Transcripts:ENST00000337532, ENST00000375719, ENST00000375732, ENST00000441595, ENST00000445954, ENST00000474682, ENST00000474731, ENST00000481244, ENST00000496637, ENST00000540098
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1442 1306 269 51 136 14 2043 721 164 112 368 505 44 59 1337 4
Low 984 1578 1316 449 1435 328 2231 1382 3062 294 1069 1082 125 1143 1451
Below cutoff 7 100 138 121 340 121 65 89 482 12 13 20 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001318170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_134518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005252369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011519337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011519338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC022021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL390866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG542434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ774044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY040628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000337532   ⟹   ENSP00000337907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,050,993 - 28,280,142 (-)Ensembl
RefSeq Acc Id: ENST00000375719   ⟹   ENSP00000364871
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,054,061 - 28,282,089 (-)Ensembl
RefSeq Acc Id: ENST00000375732   ⟹   ENSP00000364884
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,050,993 - 28,282,138 (-)Ensembl
RefSeq Acc Id: ENST00000441595   ⟹   ENSP00000398319
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,054,143 - 28,334,486 (-)Ensembl
RefSeq Acc Id: ENST00000474682
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,236,601 - 28,238,700 (-)Ensembl
RefSeq Acc Id: ENST00000474731
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,125,010 - 28,203,232 (-)Ensembl
RefSeq Acc Id: ENST00000481244
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,124,072 - 28,282,106 (-)Ensembl
RefSeq Acc Id: ENST00000496637   ⟹   ENSP00000473899
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1028,051,168 - 28,238,737 (-)Ensembl
RefSeq Acc Id: NM_001318170   ⟹   NP_001305099
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,050,993 - 28,303,064 (-)NCBI
CHM1_11028,339,855 - 28,591,938 (-)NCBI
Sequence:
RefSeq Acc Id: NM_173496   ⟹   NP_775767
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,050,993 - 28,282,123 (-)NCBI
GRCh371028,339,922 - 28,591,953 (-)NCBI
Build 361028,379,928 - 28,611,073 (-)NCBI Archive
Celera1028,103,324 - 28,334,425 (-)RGD
HuRef1028,057,989 - 28,289,085 (-)ENTREZGENE
CHM1_11028,339,855 - 28,570,969 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134517
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,050,993 - 28,303,064 (-)NCBI
CHM1_11028,339,855 - 28,591,938 (-)NCBI
Sequence:
RefSeq Acc Id: NR_134518
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,050,993 - 28,303,064 (-)NCBI
CHM1_11028,339,855 - 28,591,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005252369   ⟹   XP_005252426
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,118,859 - 28,303,024 (-)NCBI
GRCh371028,339,922 - 28,591,953 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011519337   ⟹   XP_011517639
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,051,168 - 28,282,099 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011519338   ⟹   XP_011517640
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,051,168 - 28,303,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017015741   ⟹   XP_016871230
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,051,168 - 28,281,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017015742   ⟹   XP_016871231
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,051,168 - 28,303,011 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017015743   ⟹   XP_016871232
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381028,118,859 - 28,281,067 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_775767   ⟸   NM_173496
- UniProtKB: Q5T2T1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005252426   ⟸   XM_005252369
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011517640   ⟸   XM_011519338
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011517639   ⟸   XM_011519337
- Peptide Label: isoform X2
- UniProtKB: Q5T2T1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001305099   ⟸   NM_001318170
- UniProtKB: Q5T2T1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016871231   ⟸   XM_017015742
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016871230   ⟸   XM_017015741
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016871232   ⟸   XM_017015743
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000364871   ⟸   ENST00000375719
RefSeq Acc Id: ENSP00000364884   ⟸   ENST00000375732
RefSeq Acc Id: ENSP00000337907   ⟸   ENST00000337532
RefSeq Acc Id: ENSP00000398319   ⟸   ENST00000441595
RefSeq Acc Id: ENSP00000473899   ⟸   ENST00000496637
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10p12.1-11.23(chr10:27046685-30228891)x1 copy number loss See cases [RCV000052503] Chr10:27046685..30228891 [GRCh38]
Chr10:27335614..30517820 [GRCh37]
Chr10:27375620..30557826 [NCBI36]
Chr10:10p12.1-11.23
pathogenic
GRCh38/hg38 10p12.1-11.23(chr10:27767970-30046085)x3 copy number gain See cases [RCV000053556] Chr10:27767970..30046085 [GRCh38]
Chr10:28056899..30335014 [GRCh37]
Chr10:28096905..30375020 [NCBI36]
Chr10:10p12.1-11.23
pathogenic
GRCh38/hg38 10p15.3-12.1(chr10:90421-29058318)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|See cases [RCV000053512] Chr10:90421..29058318 [GRCh38]
Chr10:224406..29347247 [GRCh37]
Chr10:126361..29387253 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
NM_173496.3(MPP7):c.420C>T (p.Ile140=) single nucleotide variant Malignant melanoma [RCV000068912] Chr10:28131587 [GRCh38]
Chr10:28420516 [GRCh37]
Chr10:28460522 [NCBI36]
Chr10:10p12.1
not provided
NM_173496.3(MPP7):c.953-4288C>T single nucleotide variant Lung cancer [RCV000108937] Chr10:28094129 [GRCh38]
Chr10:28383058 [GRCh37]
Chr10:10p12.1
uncertain significance
GRCh38/hg38 10p12.31-11.22(chr10:19088161-32732293)x3 copy number gain See cases [RCV000139427] Chr10:19088161..32732293 [GRCh38]
Chr10:19377090..33021221 [GRCh37]
Chr10:19417096..33061227 [NCBI36]
Chr10:10p12.31-11.22
likely pathogenic
GRCh38/hg38 10p12.1(chr10:27729990-28399765)x4 copy number gain See cases [RCV000139645] Chr10:27729990..28399765 [GRCh38]
Chr10:28018919..28688694 [GRCh37]
Chr10:28058925..28728700 [NCBI36]
Chr10:10p12.1
uncertain significance
GRCh38/hg38 10p12.1-11.23(chr10:26823016-30248926)x1 copy number loss See cases [RCV000139515] Chr10:26823016..30248926 [GRCh38]
Chr10:27111945..30537855 [GRCh37]
Chr10:27151951..30577861 [NCBI36]
Chr10:10p12.1-11.23
pathogenic
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22
benign
GRCh37/hg19 10p15.3-11.23(chr10:100026-30278548)x3 copy number gain See cases [RCV000447131] Chr10:100026..30278548 [GRCh37]
Chr10:10p15.3-11.23
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q11.23(chr10:100026-50961640)x3 copy number gain See cases [RCV000510893] Chr10:100026..50961640 [GRCh37]
Chr10:10p15.3-q11.23
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p12.1(chr10:28505423-28511507)x1 copy number loss not provided [RCV000737059] Chr10:28505423..28511507 [GRCh37]
Chr10:10p12.1
benign
GRCh37/hg19 10p12.1(chr10:28564732-28572424)x1 copy number loss not provided [RCV000737060] Chr10:28564732..28572424 [GRCh37]
Chr10:10p12.1
benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_173496.5(MPP7):c.316G>A (p.Ala106Thr) single nucleotide variant not provided [RCV000960050] Chr10:28131691 [GRCh38]
Chr10:28420620 [GRCh37]
Chr10:10p12.1
likely benign
GRCh37/hg19 10p12.1(chr10:28415411-28567868)x1 copy number loss not provided [RCV000847237] Chr10:28415411..28567868 [GRCh37]
Chr10:10p12.1
uncertain significance
GRCh37/hg19 10p12.1(chr10:28400603-28471614)x3 copy number gain not provided [RCV000848609] Chr10:28400603..28471614 [GRCh37]
Chr10:10p12.1
uncertain significance
GRCh37/hg19 10p12.1(chr10:27302866-28355945)x3 copy number gain not provided [RCV001006302] Chr10:27302866..28355945 [GRCh37]
Chr10:10p12.1
uncertain significance
GRCh37/hg19 10p12.1(chr10:27265783-28643506)x1 copy number loss not provided [RCV001259541] Chr10:27265783..28643506 [GRCh37]
Chr10:10p12.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26542 AgrOrtholog
COSMIC MPP7 COSMIC
Ensembl Genes ENSG00000150054 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000337907 UniProtKB/Swiss-Prot
  ENSP00000364871 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000364884 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000398319 UniProtKB/TrEMBL
  ENSP00000473899 UniProtKB/TrEMBL
Ensembl Transcript ENST00000337532 UniProtKB/Swiss-Prot
  ENST00000375719 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000375732 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000441595 UniProtKB/TrEMBL
  ENST00000496637 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000150054 GTEx
HGNC ID HGNC:26542 ENTREZGENE
Human Proteome Map MPP7 Human Proteome Map
InterPro GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPP7_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:143098 UniProtKB/Swiss-Prot
NCBI Gene 143098 ENTREZGENE
OMIM 610973 OMIM
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134985345 PharmGKB
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MPP7_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  S4R337_HUMAN UniProtKB/TrEMBL
  U5GXS2_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2RCC9 UniProtKB/Swiss-Prot
  B4DWL9 UniProtKB/Swiss-Prot
  B5MDZ3 UniProtKB/Swiss-Prot
  D3DRW3 UniProtKB/Swiss-Prot
  Q5T2T0 UniProtKB/Swiss-Prot
  Q8IY28 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 MPP7  membrane palmitoylated protein 7  MPP7  membrane protein, palmitoylated 7  Symbol and/or name change 5135510 APPROVED
2015-11-17 MPP7  membrane protein, palmitoylated 7  MPP7  membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)  Symbol and/or name change 5135510 APPROVED