PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html ).
Term: thyroid cancer pathway
Accession: PW:0000698
browse the term
Definition: Thyroid cancer refers to one of several types of malignant tumors of the thyroid gland of which papillary thyroid cancer is the most frequent, accounting for almost 80% of all cases. The other types include follicular, medullary and anaplastic.
Synonyms: exact_synonym: malignant neoplasm of thyroid gland pathway; malignant tumor of thyroid gland pathway
related_synonym: KEGG:05216; thyroid neoplasm pathway
Symbol
Object Name
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05216
NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
G
Ccdc6
coiled-coil domain containing 6
IEA
KEGG
rno:05216
NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,433,695...18,528,658
G
Ccnd1
cyclin D1
IEA
KEGG
rno:05216
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
G
Cdh1
cadherin 1
IEA
KEGG
rno:05216
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
G
Ctnnb1
catenin beta 1
IEA
KEGG
rno:05216
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
G
Hras
HRas proto-oncogene, GTPase
IEA
KEGG
rno:05216
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
G
Kras
KRAS proto-oncogene, GTPase
IEA
KEGG
rno:05216
NCBI chr 4:179,916,255...179,949,613
G
Lef1
lymphoid enhancer binding factor 1
IEA
KEGG
rno:05216
NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794
G
Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:05216
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
G
Map2k2
mitogen activated protein kinase kinase 2
IEA
KEGG
rno:05216
NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
G
Mapk1
mitogen activated protein kinase 1
IEA
KEGG
rno:05216
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
IEA
KEGG
rno:05216
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Myc
MYC proto-oncogene, bHLH transcription factor
IEA
KEGG
rno:05216
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
G
Ncoa4
nuclear receptor coactivator 4
IEA
KEGG
rno:05216
NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
G
Nras
NRAS proto-oncogene, GTPase
IEA
KEGG
rno:05216
NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:190,582,918...190,591,626
G
Ntrk1
neurotrophic receptor tyrosine kinase 1
IEA
KEGG
rno:05216
NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770
G
Pax8
paired box 8
IEA
KEGG
rno:05216
NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:7,185,723...7,242,363
G
Pparg
peroxisome proliferator-activated receptor gamma
IEA
KEGG
rno:05216
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Ret
ret proto-oncogene
IEA
KEGG
rno:05216
NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176
G
Rxra
retinoid X receptor alpha
IEA
KEGG
rno:05216
NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712
G
Rxrb
retinoid X receptor beta
IEA
KEGG
rno:05216
NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,816,815...4,828,773
G
Rxrg
retinoid X receptor gamma
IEA
KEGG
rno:05216
NCBI chr13:82,276,330...82,318,097
Ensembl chr13:79,743,563...79,785,167
G
Tcf3
transcription factor 3
IEA
KEGG
rno:05216
NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314
G
Tcf7
transcription factor 7
IEA
KEGG
rno:05216
NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535
G
Tcf7l2
transcription factor 7 like 2
IEA
KEGG
rno:05216
NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967
G
Tfg
trafficking from ER to golgi regulator
IEA
KEGG
rno:05216
NCBI chr11:57,354,607...57,381,071
Ensembl chr11:43,885,661...43,911,976
G
Tp53
tumor protein p53
IEA
KEGG
rno:05216
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Tpm3
tropomyosin 3
IEA
KEGG
rno:05216
NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013
G
Tpr
translocated promoter region, nuclear basket protein
IEA
KEGG
rno:05216
NCBI chr13:64,974,419...65,037,604
Ensembl chr13:62,424,312...62,487,496
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