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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal neuron morphology
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Accession:MP:0002882 term browser browse the term
Definition:any structural anomaly of the cells of the nervous system that receive, conduct, and transmit impulses
Synonyms:exact_synonym: neuron dysplasia


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abnormal neuron morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit IMP RGD PMID:26873552 RGD:11573213 NCBI chr14:83,089,000...83,219,576
Ensembl chr14:83,089,000...83,219,464
JBrowse link
G Depdc5em1Kyo DEP domain containing 5, GATOR1 subcomplex subunit; TALEN induced mutant1, Kyo IMP RGD PMID:26873552 RGD:11573213
G Depdc5em2Kyo DEP domain containing 5, GATOR1 subcomplex subunit; TALEN induced mutant2, Kyo IMP RGD PMID:26873552 RGD:11573213
abnormal axon morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrn attractin IAGP RGD PMID:12379762 RGD:1299186 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
JBrowse link
G Atrnmv attractin; myelin vacuolation mutant IAGP RGD PMID:12379762 RGD:1299186
abnormal dendrite morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase IMP inhibition in the nucleus accumbens decreases dendrite density of medium spiny neurons RGD PMID:18602949 RGD:2301736 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
abnormal hippocampal pyramidal neuron dendrite morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shank2 SH3 and multiple ankyrin repeat domains 2 IMP RGD PMID:29970986 RGD:126790534 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Shank2em13Sage SH3 and multiple ankyrin repeat domains 2; ZFN induced mutant13, Sage IMP RGD PMID:29970986 RGD:126790534
abnormal motor neuron dendrite morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cplx1 complexin 1 IMP RGD PMID:31875236 RGD:127285808 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598
JBrowse link
abnormal neuron number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir195 microRNA 195 IMP in hippocampus RGD PMID:32272873 RGD:45073134 NCBI chr10:56,845,301...56,845,387
Ensembl chr10:56,845,301...56,845,387
JBrowse link
abnormal postsynaptic density morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf5 Kruppel-like factor 5 IMP RGD PMID:32272873 RGD:45073134 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Mir195 microRNA 195 IMP RGD PMID:32272873 RGD:45073134 NCBI chr10:56,845,301...56,845,387
Ensembl chr10:56,845,301...56,845,387
JBrowse link
abnormal retinal horizontal cell morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1f calcium voltage-gated channel subunit alpha1 F IAGP DNA:mutation:cds: c.2941C>T (rat) RGD PMID:22634626 RGD:13782386 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Cacna1f csnb calcium voltage-gated channel subunit alpha1 F; congenital stationary night blindness mutant IAGP DNA:mutation:cds: c.2941C>T (rat) RGD PMID:22634626 RGD:13782386
abnormal synaptic vesicle number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pclo piccolo (presynaptic cytomatrix protein) IMP RGD PMID:31074746 RGD:41408338 NCBI chr 4:16,454,904...17,058,921
Ensembl chr 4:16,454,904...17,058,921
JBrowse link
G PcloTn(sb-B-Geo)Fkh presynaptic cytomatrix protein; sleeping beauty transposon induced mutant, Fkh IMP RGD PMID:31074746 RGD:41408338
decreased motor neuron number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP DNA:deletion:exon: RGD PMID:28007901 RGD:12879399 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
decreased myelin sheath amount term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrn attractin IAGP RGD PMID:12379762 RGD:1299186 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
JBrowse link
G Atrnmv attractin; myelin vacuolation mutant IAGP RGD PMID:12379762 RGD:1299186
decreased myelin sheath thickness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrn attractin IAGP RGD PMID:12379762 RGD:1299186 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
JBrowse link
G Atrnmv attractin; myelin vacuolation mutant IAGP RGD PMID:12379762 RGD:1299186
G Bace1 beta-secretase 1 IMP RGD PMID:28281673 RGD:13782149 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bace1em1Sage IMP RGD PMID:28281673 RGD:13782149
G Cyfip1 cytoplasmic FMR1 interacting protein 1 IMP RGD PMID:31371763 RGD:14981598 NCBI chr 1:114,258,773...114,347,138
Ensembl chr 1:114,258,719...114,347,137
JBrowse link
G Cyfip1em1Sage cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage IMP RGD PMID:31371763 RGD:14981598
decreased neuron number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf5 Kruppel-like factor 5 IMP in hippocampus RGD PMID:32272873 RGD:45073134 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
loss of dopaminergic neurons term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase IMP RGD PMID:24969022 RGD:13210569 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Park7em1Sage parkinson protein 7; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24969022 RGD:13210569
G Pink1 PTEN induced kinase 1 IMP RGD PMID:24969022 RGD:13210569 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pink1em1Sage PTEN induced putative kinase 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24969022 RGD:13210569
photoreceptor outer segment degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmem67 transmembrane protein 67 IAGP RGD PMID:23516626 RGD:11535084 NCBI chr 5:25,666,138...25,721,056
Ensembl chr 5:25,666,137...25,721,072
JBrowse link
retinal photoreceptor degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mertk MER proto-oncogene, tyrosine kinase treatment IAGP RGD PMID:11592982 RGD:69668 NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444
JBrowse link
G Mertkrdy MER proto-oncogene, tyrosine kinase; retinal dystrophy mutant treatment IAGP RGD PMID:11592982 RGD:69668
G Pde6b phosphodiesterase 6B IMP compared to wild-type RGD PMID:31009522 RGD:40924664 NCBI chr14:2,328,690...2,371,913
Ensembl chr14:2,328,750...2,371,883
JBrowse link
G Pde6bem1Baek phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek IMP compared to wild-type RGD PMID:31009522 RGD:40924664

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5165
    nervous system phenotype 337
      abnormal nervous system morphology 190
        abnormal neuron morphology 61
          abnormal Cajal-Retzius cell morphology + 0
          abnormal GABAergic neuron morphology + 0
          abnormal Purkinje cell morphology + 1
          abnormal adrenergic neuron morphology 0
          abnormal cerebral cortex pyramidal cell morphology + 0
          abnormal cholinergic neuron morphology + 0
          abnormal dopaminergic neuron morphology + 7
          abnormal enteric neuron morphology + 0
          abnormal glutaminergic neuron morphology + 0
          abnormal glycinergic neuron morphology 0
          abnormal hippocampus neuron morphology + 0
          abnormal medium spiny neuron morphology 1
          abnormal motor neuron morphology + 13
          abnormal neurite morphology + 17
          abnormal neuroendocrine cell morphology + 0
          abnormal neuron differentiation + 0
          abnormal neuron number + 11
          abnormal neuron polarity 0
          abnormal neuron specification 0
          abnormal peptidergic neuron morphology 0
          abnormal sensory neuron morphology + 15
          abnormal serotonergic neuron morphology 0
          abnormal synapse morphology + 4
          abnormal thalamus neuron morphology 0
          chromatolysis 0
          ectopic neuron + 0
          neuron degeneration + 16
          neuron hypertrophy 0
          neuronal cytoplasmic inclusions 0
          neuronal intranuclear inclusions 1
paths to the root