Park7<sup>em1Sage</sup> (parkinson protein 7; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Park7em1Sage (parkinson protein 7; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Park7em1Sage
Name: parkinson protein 7; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 7241042
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 9-bp deletion with 1-bp insertion in exon 5 (TTGGTGAAGA)
ASSOCIATED WITH abnormal gait; abnormal motor coordination/balance; abnormal muscle tone; ASSOCIATED WITH Parkinson's disease
Type: allele  of Park7  
Previously known as: Park7^[em1Sage]; Park7em1Sage
Is Marker For: Strains:   LE-Park7em1Sage   LE-Park7em1Sage-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map5 RGD


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
2. Data registered by Sigma Advanced Genetic Engineering Labs Personal communication with SAGE Labs and RGD curators
3. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.

Genomics


Related Rat Strains
The following Strains have been annotated to Park7em1Sage
LE-Park7em1Sage-/-     LE-Park7em1Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information