Cyfip1<sup>em1Sage</sup> (cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage) - Rat Genome Database

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Gene: Cyfip1em1Sage (cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage) Rattus norvegicus
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Symbol: Cyfip1em1Sage
Name: cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage
RGD ID: 14985211
Description: The guide RNA (sgRNA) targeting a Protospacer Adjacent Motif (PAM) sequence within exon 7 of the rat Cyfip1gene (GGCAGATCCACAATCCATCCagg) on chromosome 1 (first 21 of 32 exons, Refseq: NC_005100.4, NM_001107517.1) was injected to Long Evans one cell embryos. The resultant mutation is 4 bp out of frame deletion in exon 7 of the rat Cyfip1, resulting an early stop codon in exon 8.
ASSOCIATED WITH abnormal brain white matter morphology; decreased myelin sheath thickness; decreased oligodendrocyte number
Type: allele  of Cyfip1  
Is Marker For: Strains:   LE-Cyfip1em1Sage+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Silva AI, etal., Nat Commun. 2019 Aug 1;10(1):3455. doi: 10.1038/s41467-019-11119-7.

Genomics


Related Rat Strains
The following Strains have been annotated to Cyfip1em1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information