RGD Reference Report - The myelin vacuolation (mv) rat with a null mutation in the attractin gene. - Rat Genome Database

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The myelin vacuolation (mv) rat with a null mutation in the attractin gene.

Authors: Kuwamura, M  Maeda, M  Kuramoto, T  Kitada, K  Kanehara, T  Moriyama, M  Nakane, Y  Yamate, J  Ushijima, T  Kotani, T  Serikawa, T 
Citation: Kuwamura M, etal., Lab Invest 2002 Oct;82(10):1279-86.
RGD ID: 1299186
Pubmed: (View Article at PubMed) PMID:12379762

We recently found a spontaneous tremor mutant in an outbred colony of Sprague-Dawley rats. The tremor behavior was exhibited from around 3 weeks of age and inherited as an autosomal recessive trait. The mutant rats had variously sized vacuoles in the neuropil and white matter throughout the central nervous system, especially in the brain stem, cerebellum, and spinal cord. Ultrastructurally these vacuoles mainly consisted of splitting of myelin lamella both in the periaxonal and intermyelinic spaces. Linkage analysis using intercross progeny between the myelin vacuolation (mv) rat, named after the pathologic characteristics, and normal control rat strains showed that the mv phenotypes were cosegregated with polymorphic markers adjacent to the Atrn (Attractin, formerly zi [zitter]) locus on rat chromosome 3. A test for allelism suggested that the mv mutation was a new allele in ATRN: In comparison with a marked decrease of Atrn(zi)/Arn(zi), Northern blot analysis revealed no expression of Atrn mRNA in the brain of the mv rats. Finally, a genomic deletion including exon 1 of the mv rats was detected by genomic and sequence analyses. Discovery of the rat null mutation Atrn(mv), different from Atrn(zi), provides a new animal model for studying the functions of the attractin protein.

Annotation

Disease Annotations    
Tremor  (IAGP,ISO)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Atrn  (attractin)
Atrnmv  (attractin; myelin vacuolation mutant)

Genes (Mus musculus)
Atrn  (attractin)

Genes (Homo sapiens)
ATRN  (attractin)

Strains
MV/Opu  (myelin vacuolation rat)

Objects referenced in this article
0 Batf basic leucine zipper ATF-like transcription factor All species
0 Lpcat3 lysophosphatidylcholine acyltransferase 3 All species

Additional Information