Pclo (piccolo (presynaptic cytomatrix protein)) - Rat Genome Database

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Gene: Pclo (piccolo (presynaptic cytomatrix protein)) Rattus norvegicus
Analyze
Symbol: Pclo
Name: piccolo (presynaptic cytomatrix protein)
RGD ID: 69406
Description: Enables calcium ion binding activity; calcium-dependent phospholipid binding activity; and transcription corepressor binding activity. Involved in several processes, including positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; and regulation of endosome size. Located in several cellular components, including cytoplasmic vesicle; distal axon; and rod spherule. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aczonin; LOC108350654; multidomain presynaptic cytomatrix protein Piccolo; presynaptic cytomatrix protein; protein piccolo; protein piccolo-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: PcloTn(sb-B-Geo)Fkh  
Genetic Models: WI.SD-PcloTn(sb-B-Geo)Fkh
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: This gene aligns across a gap in the Rnor_6.0 reference genome assembly, and therefore, the 5' end of this gene was annotated on NW_007905776.1 and the 3' end was annotated on NW_007905775.1 in NCBI's Rattus norvegicus Annotation Release 105. [15 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2419,691,439 - 20,050,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl419,695,315 - 20,049,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx424,865,942 - 25,222,133 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0420,697,245 - 21,053,987 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0419,078,298 - 19,437,003 (-)NCBIRnor_WKY
Rnor_6.0416,454,904 - 17,058,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl416,454,904 - 17,058,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0416,923,700 - 17,031,648 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0416,428,814 - 16,661,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4415,911,051 - 16,269,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1415,911,050 - 16,269,090 (-)NCBI
Celera415,219,539 - 15,569,109 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, etal., Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629.
2. Localization of the presynaptic cytomatrix protein Piccolo at ribbon and conventional synapses in the rat retina: comparison with Bassoon. Dick O, etal., J Comp Neurol. 2001 Oct 15;439(2):224-34.
3. Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment. Dresbach T, etal., J Biol Chem. 2006 Mar 3;281(9):6038-47. Epub 2005 Dec 21.
4. Gene structure and genetic localization of the PCLO gene encoding the presynaptic active zone protein Piccolo. Fenster SD and Garner CC, Int J Dev Neurosci 2002 Jun-Aug;20(3-5):161-71.
5. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Fenster SD, etal., Neuron 2000 Jan;25(1):203-14.
6. A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Garcia J, etal., Nat Struct Mol Biol. 2004 Jan;11(1):45-53. Epub 2003 Dec 29.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release. Gerber SH, etal., EMBO J 2001 Apr 2;20(7):1605-19.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. Ivanova D, etal., EMBO J. 2015 Apr 15;34(8):1056-77. doi: 10.15252/embj.201488796. Epub 2015 Feb 4.
11. Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification. Juranek J, etal., Eur J Neurosci. 2006 Dec;24(11):3043-52.
12. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
13. Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site. Limbach C, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):E392-401. doi: 10.1073/pnas.1101707108. Epub 2011 Jun 28.
14. Formation of Golgi-derived active zone precursor vesicles. Maas C, etal., J Neurosci. 2012 Aug 8;32(32):11095-108. doi: 10.1523/JNEUROSCI.0195-12.2012.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Immunogold labeling of synaptic vesicle proteins in developing hippocampal neurons. Tao-Cheng JH, Mol Brain. 2020 Jan 20;13(1):9. doi: 10.1186/s13041-020-0549-x.
21. Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation. Waites CL, etal., EMBO J. 2013 Apr 3;32(7):954-69. doi: 10.1038/emboj.2013.27. Epub 2013 Feb 12.
22. Assembling the presynaptic active zone: a characterization of an active one precursor vesicle. Zhai RG, etal., Neuron. 2001 Jan;29(1):131-43.
Additional References at PubMed
PMID:10508862   PMID:12401793   PMID:17114649   PMID:18519737   PMID:18570454   PMID:19812333   PMID:20127803   PMID:20332206   PMID:21144999   PMID:21700703   PMID:23936420   PMID:25897839  
PMID:26793095   PMID:27907191   PMID:29194628   PMID:29476059   PMID:30053369   PMID:32122952  


Genomics

Comparative Map Data
Pclo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2419,691,439 - 20,050,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl419,695,315 - 20,049,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx424,865,942 - 25,222,133 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0420,697,245 - 21,053,987 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0419,078,298 - 19,437,003 (-)NCBIRnor_WKY
Rnor_6.0416,454,904 - 17,058,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl416,454,904 - 17,058,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0416,923,700 - 17,031,648 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0416,428,814 - 16,661,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4415,911,051 - 16,269,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1415,911,050 - 16,269,090 (-)NCBI
Celera415,219,539 - 15,569,109 (-)NCBICelera
Cytogenetic Map4q12NCBI
PCLO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38782,754,012 - 83,162,884 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl782,754,012 - 83,162,930 (-)EnsemblGRCh38hg38GRCh38
GRCh37782,383,328 - 82,792,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36782,225,378 - 82,630,133 (-)NCBINCBI36Build 36hg18NCBI36
Build 34782,188,346 - 82,224,200NCBI
Celera777,083,829 - 77,492,761 (-)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef776,984,730 - 77,393,999 (-)NCBIHuRef
CHM1_1782,313,403 - 82,722,210 (-)NCBICHM1_1
T2T-CHM13v2.0784,005,231 - 84,414,103 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2781,715,437 - 82,124,409 (-)NCBI
Pclo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39514,564,924 - 14,913,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl514,564,932 - 14,913,473 (+)EnsemblGRCm39 Ensembl
GRCm38514,514,906 - 14,863,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl514,514,918 - 14,863,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37514,514,918 - 14,863,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36514,520,924 - 14,801,999 (+)NCBIMGSCv36mm8
Celera1224,890,712 - 25,239,859 (+)NCBICelera
Cytogenetic Map5A1- A2NCBI
Pclo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554103,152,202 - 3,292,920 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554102,998,345 - 3,334,056 (+)NCBIChiLan1.0ChiLan1.0
PCLO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1788,378,218 - 88,789,302 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0774,714,364 - 75,126,518 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PCLO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11822,385,102 - 22,701,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1822,385,100 - 22,706,793 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,995,716 - 22,385,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01822,770,098 - 23,160,278 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1822,770,852 - 22,983,764 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11822,405,472 - 22,795,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01821,940,459 - 22,330,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01822,596,545 - 22,986,291 (-)NCBIUU_Cfam_GSD_1.0
Pclo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511864,071,317 - 64,473,183 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367341,277,591 - 1,479,521 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367341,273,055 - 1,674,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCLO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl997,114,511 - 97,513,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1997,114,503 - 97,513,081 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29107,331,780 - 107,730,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCLO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12165,729,762 - 66,129,806 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604237,825,087 - 38,233,533 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pclo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473931,143,872 - 31,448,524 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pclo
1889 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:656
Count of miRNA genes:183
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000007608, ENSRNOT00000008637
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat

Markers in Region
D4Rat150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2419,944,524 - 19,944,727 (+)MAPPERmRatBN7.2
Rnor_6.0416,721,186 - 16,721,388NCBIRnor6.0
Rnor_5.0416,697,210 - 16,697,412UniSTSRnor5.0
RGSC_v3.4416,163,196 - 16,163,399RGDRGSC3.4
RGSC_v3.4416,163,197 - 16,163,399UniSTSRGSC3.4
RGSC_v3.1416,163,193 - 16,163,553RGD
Celera415,463,961 - 15,464,163UniSTS
SHRSP x BN Map47.92UniSTS
SHRSP x BN Map47.92RGD
Cytogenetic Map4q12UniSTS
RH132306  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2419,753,275 - 19,753,463 (+)MAPPERmRatBN7.2
Rnor_6.0416,517,622 - 16,517,809NCBIRnor6.0
Rnor_5.0416,491,458 - 16,491,645UniSTSRnor5.0
RGSC_v3.4415,969,717 - 15,969,904UniSTSRGSC3.4
Celera415,277,119 - 15,277,306UniSTS
Cytogenetic Map4q12UniSTS
BE121235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2419,762,347 - 19,762,524 (+)MAPPERmRatBN7.2
Rnor_6.0416,526,692 - 16,526,868NCBIRnor6.0
Rnor_5.0416,500,528 - 16,500,704UniSTSRnor5.0
RGSC_v3.4415,978,787 - 15,978,963UniSTSRGSC3.4
Celera415,286,190 - 15,286,366UniSTS
Cytogenetic Map4q12UniSTS


Genetic Models
This gene Pclo is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 56
Low 2 12 4 7 4 2 2 18 25 15 10 2
Below cutoff 1 30 41 33 12 33 6 6 10 25 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007608   ⟹   ENSRNOP00000007608
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl419,754,934 - 20,049,885 (-)Ensembl
Rnor_6.0 Ensembl416,496,895 - 16,669,368 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000008637   ⟹   ENSRNOP00000008637
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl419,695,315 - 20,049,885 (-)Ensembl
Rnor_6.0 Ensembl416,519,487 - 16,654,811 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093412
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl416,454,904 - 17,058,921 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl416,519,487 - 17,058,921 (-)Ensembl
RefSeq Acc Id: NM_001110797   ⟹   NP_001104267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,755,141 - 20,049,885 (-)NCBI
Rnor_6.0416,519,487 - 17,058,921 (-)NCBI
Rnor_5.0416,428,814 - 16,661,584 (-)NCBI
Rnor_5.0416,923,700 - 17,031,648 (-)NCBI
RGSC_v3.4415,911,051 - 16,269,090 (-)RGD
Celera415,278,984 - 15,569,109 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020098   ⟹   NP_064483
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,695,315 - 20,049,885 (-)NCBI
Rnor_6.0416,454,904 - 17,058,921 (-)NCBI
Rnor_5.0416,428,814 - 16,661,584 (-)NCBI
Rnor_5.0416,923,700 - 17,031,648 (-)NCBI
RGSC_v3.4415,911,051 - 16,269,090 (-)RGD
Celera415,219,539 - 15,569,109 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108289   ⟹   XP_038964217
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,691,439 - 20,050,015 (-)NCBI
RefSeq Acc Id: XM_039108290   ⟹   XP_038964218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,691,439 - 20,050,015 (-)NCBI
RefSeq Acc Id: XM_039108291   ⟹   XP_038964219
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,691,439 - 20,050,015 (-)NCBI
RefSeq Acc Id: XM_039108294   ⟹   XP_038964222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,691,439 - 20,050,015 (-)NCBI
RefSeq Acc Id: XM_039108295   ⟹   XP_038964223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2419,691,439 - 20,050,015 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_064483   ⟸   NM_020098
- Peptide Label: isoform 1
- UniProtKB: D3Z9C7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104267   ⟸   NM_001110797
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: ENSRNOP00000008637   ⟸   ENSRNOT00000008637
RefSeq Acc Id: ENSRNOP00000007608   ⟸   ENSRNOT00000007608
RefSeq Acc Id: XP_038964223   ⟸   XM_039108295
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038964219   ⟸   XM_039108291
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964218   ⟸   XM_039108290
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964222   ⟸   XM_039108294
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038964217   ⟸   XM_039108289
- Peptide Label: isoform X1
Protein Domains
C2   PDZ

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69406 AgrOrtholog
BioCyc Gene G2FUF-45890 BioCyc
Ensembl Genes ENSRNOG00000005726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007608 ENTREZGENE
  ENSRNOP00000007608.8 UniProtKB/TrEMBL
  ENSRNOP00000008637 ENTREZGENE
  ENSRNOP00000008637.8 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007608 ENTREZGENE
  ENSRNOT00000007608.8 UniProtKB/TrEMBL
  ENSRNOT00000008637 ENTREZGENE
  ENSRNOT00000008637.9 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCLO_FYVE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piccolo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_piccolo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56768 UniProtKB/Swiss-Prot
NCBI Gene 56768 ENTREZGENE
PANTHER PTHR14113:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-piccolo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pclo PhenoGen
PRINTS C2DOMAIN UniProtKB/TrEMBL
  SYNAPTOTAGMN UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt D3Z9C7 ENTREZGENE, UniProtKB/TrEMBL
  F1M7V4_RAT UniProtKB/TrEMBL
  PCLO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JLT1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pclo  piccolo (presynaptic cytomatrix protein)  LOC108350654  protein piccolo-like  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108350654  protein piccolo-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Pclo  piccolo (presynaptic cytomatrix protein)    presynaptic cytomatrix protein  Name updated 1299863 APPROVED
2002-06-10 Pclo  presynaptic cytomatrix protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the presynaptic cytoskeletal matrix 69383
gene_function binds Ca2+ by virtue of its C(2)A-domain 68715
gene_process may function as a Ca2+ sensor in short-term synaptic plasticity when high Ca2+ concentrations accumulate during repetitive stimulation 68715
gene_process may function as a Ca2+ sensor in short-term synaptic plasticity when high Ca2+ concentrations accumulate during repetitive stimulation 69383
gene_process involved in the assembly and function of presynaptic active zones as sites of neurotransmitter release 1299209