RGD Reference Report - Retinal horizontal cells reduced in a rat model of congenital stationary night blindness. - Rat Genome Database

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Retinal horizontal cells reduced in a rat model of congenital stationary night blindness.

Authors: Zheng, Lijuan  Yan, Yili  An, Jing  Zhang, Lei  Liu, Wei  Xia, Feng  Zhang, Zuoming 
Citation: Zheng L, etal., Neurosci Lett. 2012 Jul 11;521(1):26-30. doi: 10.1016/j.neulet.2012.05.049. Epub 2012 May 24.
RGD ID: 13782386
Pubmed: PMID:22634626   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2012.05.049   (Journal Full-text)

This work was conducted to determine whether congenital stationary night blindness (CSNB), which is caused by a Cacna1f mutation, could affect development of second-order neurons in the retina, such as horizontal cells (HCs). The CSNB rats and age-matched wild type rats were sacrificed at postnatal days (PND) 15, 30 and 60. Morphometric analyses of HCs, which were labeled by a primary antibody to calbindin D-28K, were performed at the light microscopic level on retinal cross sections and whole mount retinas. Calbindin D-28K was measured by western blotting in retinal samples. We found that the average number and density of HCs, Calbindin level and thickness of OPL were all decreased significantly in CSNB group compared to control group. These results indicated that second-order retinal neurons, such as horizontal cells, are affected by retinal degeneration. The relationship between the absence of HCs and the gene defect of CSNB requires further research.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cacna1fRatabnormal retina horizontal cell morphology  IAGP DNA:mutation:cds: c.2941C>T ratRGD 
Cacna1f csnbRatabnormal retina horizontal cell morphology  IAGP DNA:mutation:cds: c.2941C>T ratRGD 
SD-Cacna1f csnbRatabnormal retina horizontal cell morphology  IAGP DNA:mutation:cds: c.2941C>T ratRGD 
Cacna1fRatthin retina outer plexiform layer  IAGP DNA:mutation:cds: c.2941C>T ratRGD 
Cacna1f csnbRatthin retina outer plexiform layer  IAGP DNA:mutation:cds: c.2941C>T ratRGD 
SD-Cacna1f csnbRatthin retina outer plexiform layer  IAGP DNA:mutation:cds: c.2941C>T ratRGD 
Objects Annotated

Genes (Rattus norvegicus)
Cacna1f  (calcium voltage-gated channel subunit alpha1 F)
Cacna1f csnb  (calcium voltage-gated channel subunit alpha1 F; congenital stationary night blindness mutant)

Strains
SD-Cacna1f csnb  (congenital stationary night blindness rat)


Additional Information