Cyfip1 (cytoplasmic FMR1 interacting protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cyfip1 (cytoplasmic FMR1 interacting protein 1) Rattus norvegicus
Analyze
Symbol: Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
RGD ID: 1310332
Description: Enables RNA 7-methylguanosine cap binding activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; and positive regulation of cell projection organization. Located in several cellular components, including dendritic spine; distal axon; and filopodium tip. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytoplasmic FMR1-interacting protein 1; LOC308666
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cyfip1em1Sage  
Genetic Models: LE-Cyfip1em1Sage+/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21106,710,924 - 106,799,393 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1106,711,016 - 106,799,386 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1112,100,298 - 112,189,006 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01120,572,167 - 120,660,875 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01113,821,095 - 113,909,828 (+)NCBIRnor_WKY
Rnor_6.01114,258,773 - 114,347,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,258,719 - 114,347,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01115,265,128 - 115,353,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41107,245,993 - 107,334,337 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11107,324,324 - 107,412,679 (+)NCBI
Celera1100,921,447 - 101,009,775 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. Bozdagi O, etal., PLoS One. 2012;7(8):e42422. doi: 10.1371/journal.pone.0042422. Epub 2012 Aug 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Cyfip1 Regulates Presynaptic Activity during Development. Hsiao K, etal., J Neurosci. 2016 Feb 3;36(5):1564-76. doi: 10.1523/JNEUROSCI.0511-15.2016.
4. Up-regulated cytoplasmic FMRP-interacting protein 1 in intractable temporal lobe epilepsy patients and a rat model. Huang Y Int J Neurosci. 2015 Aug 24:1-10.
5. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Kawano Y, etal., Mol Cell Biol. 2005 Nov;25(22):9920-35.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. The Prader-Willi phenotype of fragile X syndrome. Nowicki ST, etal., J Dev Behav Pediatr. 2007 Apr;28(2):133-8.
8. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Panja D, etal., Cell Rep. 2014 Nov 20;9(4):1430-45. doi: 10.1016/j.celrep.2014.10.016. Epub 2014 Nov 6.
9. The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines. Pathania M, etal., Transl Psychiatry. 2014 Mar 25;4:e374. doi: 10.1038/tp.2014.16.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
13. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Silva AI, etal., Nat Commun. 2019 Aug 1;10(1):3455. doi: 10.1038/s41467-019-11119-7.
14. Confirmed rare copy number variants implicate novel genes in schizophrenia. Tam GW, etal., Biochem Soc Trans. 2010 Apr;38(2):445-51. doi: 10.1042/BST0380445.
15. A co-segregating microduplication of chromosome 15q11.2 pinpoints two risk genes for autism spectrum disorder. van der Zwaag B, etal., Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):960-6. doi: 10.1002/ajmg.b.31055.
16. Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders. Waltes R, etal., Hum Genet. 2014 Jun;133(6):781-92. doi: 10.1007/s00439-013-1416-y. Epub 2014 Jan 19.
Additional References at PubMed
PMID:11438699   PMID:14765121   PMID:16025302   PMID:17519220   PMID:18560548   PMID:18805096   PMID:20458337   PMID:21107423   PMID:21423176   PMID:23533145   PMID:24050404   PMID:27605705  
PMID:30361391  


Genomics

Comparative Map Data
Cyfip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21106,710,924 - 106,799,393 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1106,711,016 - 106,799,386 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1112,100,298 - 112,189,006 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01120,572,167 - 120,660,875 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01113,821,095 - 113,909,828 (+)NCBIRnor_WKY
Rnor_6.01114,258,773 - 114,347,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,258,719 - 114,347,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01115,265,128 - 115,353,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41107,245,993 - 107,334,337 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11107,324,324 - 107,412,679 (+)NCBI
Celera1100,921,447 - 101,009,775 (+)NCBICelera
Cytogenetic Map1q22NCBI
CYFIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381522,867,052 - 22,980,898 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1522,867,052 - 22,981,063 (-)EnsemblGRCh38hg38GRCh38
GRCh371522,892,170 - 23,006,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361520,444,125 - 20,555,044 (+)NCBINCBI36Build 36hg18NCBI36
Build 341520,444,124 - 20,555,043NCBI
Celera151,376,209 - 1,487,232 (-)NCBICelera
Cytogenetic Map15q11.2NCBI
HuRef151,205,387 - 1,315,987 (+)NCBIHuRef
CHM1_11522,841,725 - 22,952,892 (+)NCBICHM1_1
T2T-CHM13v2.01520,538,904 - 20,652,761 (-)NCBIT2T-CHM13v2.0
Cyfip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39755,491,556 - 55,582,381 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl755,491,493 - 55,582,350 (+)EnsemblGRCm39 Ensembl
GRCm38755,842,022 - 55,932,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl755,841,745 - 55,932,602 (+)EnsemblGRCm38mm10GRCm38
MGSCv37763,097,441 - 63,188,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,739,875 - 55,798,505 (+)NCBIMGSCv36mm8
Celera753,195,732 - 53,286,248 (+)NCBICelera
Cytogenetic Map7B5NCBI
CYFIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11520,462,755 - 20,573,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1520,462,811 - 20,573,684 (+)Ensemblpanpan1.1panPan2
CYFIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1332,096,471 - 32,170,107 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl332,097,037 - 32,187,781 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha334,509,239 - 34,585,945 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0332,162,887 - 32,239,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl332,117,281 - 32,240,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1331,650,943 - 31,773,999 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0331,945,859 - 32,022,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0332,056,552 - 32,133,289 (+)NCBIUU_Cfam_GSD_1.0
Cyfip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,416,388 - 120,482,622 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647138,267,703 - 38,332,218 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647138,264,455 - 38,331,995 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYFIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1532,064,475 - 32,175,094 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11532,064,431 - 32,175,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYFIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,562,105 - 53,673,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,595,767 - 53,672,977 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605436,289,010 - 36,405,036 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cyfip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248962,723,462 - 2,800,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248962,726,622 - 2,774,671 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyfip1
428 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:372
Count of miRNA genes:207
Interacting mature miRNAs:250
Transcripts:ENSRNOT00000016376
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat


Genetic Models
This gene Cyfip1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016376   ⟹   ENSRNOP00000016376
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1106,711,016 - 106,799,386 (+)Ensembl
Rnor_6.0 Ensembl1114,258,793 - 114,347,137 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088459   ⟹   ENSRNOP00000072931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1106,711,016 - 106,799,386 (+)Ensembl
Rnor_6.0 Ensembl1114,258,719 - 114,346,800 (+)Ensembl
RefSeq Acc Id: NM_001107517   ⟹   NP_001100987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21106,711,048 - 106,799,392 (+)NCBI
Rnor_6.01114,258,793 - 114,347,137 (+)NCBI
Rnor_5.01115,265,128 - 115,353,515 (+)NCBI
RGSC_v3.41107,245,993 - 107,334,337 (+)RGD
Celera1100,921,447 - 101,009,775 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229288   ⟹   XP_006229350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21106,742,524 - 106,799,393 (+)NCBI
Rnor_6.01114,258,773 - 114,347,138 (+)NCBI
Rnor_5.01115,265,128 - 115,353,515 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112486   ⟹   XP_038968414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21106,710,924 - 106,798,857 (+)NCBI
RefSeq Acc Id: XM_039112492   ⟹   XP_038968420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21106,742,524 - 106,793,953 (+)NCBI
RefSeq Acc Id: XM_039112494   ⟹   XP_038968422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21106,742,524 - 106,776,736 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100987   ⟸   NM_001107517
- UniProtKB: D4A8H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229350   ⟸   XM_006229288
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K472 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016376   ⟸   ENSRNOT00000016376
RefSeq Acc Id: ENSRNOP00000072931   ⟸   ENSRNOT00000088459
RefSeq Acc Id: XP_038968414   ⟸   XM_039112486
- Peptide Label: isoform X2
- UniProtKB: D4A8H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968420   ⟸   XM_039112492
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038968422   ⟸   XM_039112494
- Peptide Label: isoform X4
Protein Domains
CYRIA-B_Rac1-bd

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8H8-F1-model_v2 AlphaFold D4A8H8 1-1253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690084
Promoter ID:EPDNEW_R608
Type:initiation region
Name:Cyfip1_1
Description:cytoplasmic FMR1 interacting protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01114,258,808 - 114,258,868EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310332 AgrOrtholog
BioCyc Gene G2FUF-59463 BioCyc
Ensembl Genes ENSRNOG00000011945 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016376 ENTREZGENE
  ENSRNOP00000016376.5 UniProtKB/TrEMBL
  ENSRNOP00000072931 ENTREZGENE
  ENSRNOP00000072931.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016376 ENTREZGENE
  ENSRNOT00000016376.6 UniProtKB/TrEMBL
  ENSRNOT00000088459 ENTREZGENE
  ENSRNOT00000088459.2 UniProtKB/TrEMBL
InterPro Cytoplasmic_FMR1-int UniProtKB/TrEMBL
  DUF1394 UniProtKB/TrEMBL
KEGG Report rno:308666 UniProtKB/TrEMBL
NCBI Gene 308666 ENTREZGENE
PANTHER FragX_IP UniProtKB/TrEMBL
Pfam DUF1394 UniProtKB/TrEMBL
  FragX_IP UniProtKB/TrEMBL
PhenoGen Cyfip1 PhenoGen
PIRSF FMR1_interacting UniProtKB/TrEMBL
PRINTS CYTOFMRPINTP UniProtKB/TrEMBL
UniProt A0A0G2K472 ENTREZGENE, UniProtKB/TrEMBL
  D4A8H8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyfip1  cytoplasmic FMR1 interacting protein 1   Cyfip1_predicted  cytoplasmic FMR1 interacting protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyfip1_predicted  cytoplasmic FMR1 interacting protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED