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Gene: Cyfip1 (cytoplasmic FMR1 interacting protein 1) Rattus norvegicus
Symbol: Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
RGD ID: 1310332
Description: Exhibits RNA 7-methylguanosine cap binding activity. Predicted to contribute to Rac GTPase binding activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; and positive regulation of cell projection organization. Localizes to several cellular components, including dendritic spine; distal axon; and filopodium tip. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; T-2 Toxin.
Type: protein-coding
Also known as: cytoplasmic FMR1-interacting protein 1; LOC308666
Homo sapiens (human) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyfip1 (cytoplasmic FMR1 interacting protein 1)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
Canis lupus familiaris (dog) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyfip1 (cytoplasmic FMR1 interacting protein 1)
Sus scrofa (pig) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
Chlorocebus sabaeus (African green monkey) : CYFIP1 (cytoplasmic FMR1 interacting protein 1)
Heterocephalus glaber (naked mole-rat) : Cyfip1 (cytoplasmic FMR1 interacting protein 1)
more info ...
Allele / Splice: Cyfip1em1Sage  
Genetic Models: LE-Cyfip1em1Sage+/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01114,258,773 - 114,347,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,258,719 - 114,347,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01115,265,128 - 115,353,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41107,245,993 - 107,334,337 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11107,324,324 - 107,412,679 (+)NCBI
Celera1100,921,447 - 101,009,775 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Cyfip1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310332
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.