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ONTOLOGY REPORT - ANNOTATIONS

Term:cGAS/STING signaling pathway
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Accession:GO:0140896 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.


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cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:32911482), (PMID:32912999), (PMID:33542149), (PMID:35322803), (PMID:35438208), (PMID:35460603), (PMID:39322678)
(PMID:39322678)		 RGD PMID:32911482 PMID:32912999 PMID:33542149 PMID:35322803 PMID:35438208 More... NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Ddx41 DEAD-box helicase 41 involved_in ISO (PMID:35613581) RGD PMID:35613581 NCBI chr17:9,108,030...9,113,562
Ensembl chr17:9,103,010...9,108,415 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:37832545)
(PMID:25636800), (PMID:30842659), (PMID:30842662), (PMID:35388221), (PMID:37832545)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:25636800 PMID:30842659 PMID:30842662 PMID:35388221 PMID:37832545 GO_REF:0000024 GO_REF:0000107 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
negative regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars2 alanyl-tRNA synthetase 2, mitochondrial involved_in ISO
ISS
IEA		 (PMID:39322678)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:39322678 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:22,981,880...22,993,536
Ensembl chr 9:15,297,531...15,496,090 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12172553), (PMID:26440888)		 Ensembl
RGD		 PMID:12172553 PMID:26440888 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aurkb aurora kinase B involved_in IEA
ISO		 GO_REF:0000107
(PMID:33542149)		 Ensembl
RGD		 PMID:33542149 GO_REF:0000107 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Banf1 barrier to autointegration nuclear assembly factor 1 involved_in ISO (PMID:32792394) RGD PMID:32792394 NCBI chr 1:212,101,523...212,103,568
Ensembl chr 1:202,671,305...202,674,188 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:32911482), (PMID:32912999) RGD PMID:32911482 PMID:32912999 NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:32715615) RGD PMID:32715615 NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Lyplal1 lysophospholipase-like 1 involved_in ISO (PMID:37802025) RGD PMID:37802025 NCBI chr13:100,158,060...100,189,339
Ensembl chr13:97,626,451...97,657,867 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in ISO (PMID:35460603) RGD PMID:35460603 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 involved_in ISO (PMID:35322803) RGD PMID:35322803 NCBI chr 7:135,483,702...135,508,254
Ensembl chr 7:133,605,573...133,629,863 		JBrowse link
G Ppp6c protein phosphatase 6, catalytic subunit involved_in ISO (PMID:32474700) RGD PMID:32474700 NCBI chr 3:43,339,521...43,371,807
Ensembl chr 3:22,931,577...22,962,113 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (PMID:33273464) RGD PMID:33273464 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A involved_in ISS
ISO		 GO_REF:0000024
(PMID:37890481)		 UniProt
RGD		 PMID:37890481 GO_REF:0000024 NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,132,592...37,155,567 		JBrowse link
G Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 involved_in ISO (PMID:38418882) RGD PMID:38418882 NCBI chr10:14,411,692...14,417,357
Ensembl chr10:13,907,253...13,912,841 		JBrowse link
G Trex1 three prime repair exonuclease 1 involved_in ISO (PMID:33476576) RGD PMID:33476576 NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 involved_in IEA
ISO		 GO_REF:0000107
(PMID:35438208)		 Ensembl
RGD		 PMID:35438208 GO_REF:0000107 NCBI chr 5:151,105,303...151,143,843
Ensembl chr 5:145,831,446...145,859,993 		JBrowse link
positive regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase involved_in ISO (PMID:25704810) RGD PMID:25704810 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (PMID:37832545) RGD PMID:37832545 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Rnf39 ring finger protein 39 involved_in ISO (PMID:39255680) RGD PMID:39255680 NCBI chr20:1,610,027...1,615,516
Ensembl chr20:1,604,794...1,610,283 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 involved_in ISO (PMID:36745868) RGD PMID:36745868 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 involved_in ISO (PMID:37832545) RGD PMID:37832545 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Zdhhc9 zinc finger DHHC-type palmitoyltransferase 9 involved_in ISO (PMID:37802025) RGD PMID:37802025 NCBI chr  X:132,230,243...132,266,139
Ensembl chr  X:127,352,345...127,388,245 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      signal transduction 7262
        intracellular signal transduction 3155
          intracellular receptor signaling pathway 410
            cytoplasmic pattern recognition receptor signaling pathway 185
              cGAS/STING signaling pathway 23
                negative regulation of cGAS/STING signaling pathway 15
                positive regulation of cGAS/STING signaling pathway 6
Path 2
Term Annotations click to browse term
  biological_process 20553
    response to stimulus 11038
      response to biotic stimulus 1936
        response to external biotic stimulus 1888
          response to other organism 1872
            defense response to other organism 1330
              defense response to symbiont 1103
                innate immune response 1016
                  regulation of innate immune response 484
                    positive regulation of innate immune response 392
                      activation of innate immune response 322
                        innate immune response-activating signaling pathway 294
                          pattern recognition receptor signaling pathway 283
                            cytoplasmic pattern recognition receptor signaling pathway 185
                              cGAS/STING signaling pathway 23
                                negative regulation of cGAS/STING signaling pathway 15
                                positive regulation of cGAS/STING signaling pathway 6
paths to the root