Aars2 (alanyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Aars2 (alanyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
RGD ID: 1310617
Description: Predicted to have anion binding activity; catalytic activity, acting on a tRNA; and tRNA binding activity. Predicted to be involved in mitochondrial alanyl-tRNA aminoacylation and tRNA modification. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial); PARTICIPATES IN alanine metabolic pathway; lactic acidosis pathway; primary hyperoxaluria type 1 pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 1,2-dimethylhydrazine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aarsl; alanine--tRNA ligase; alanine--tRNA ligase, mitochondrial; alanyl-tRNA synthetase 2, mitochondrial (putative); alanyl-tRNA synthetase like; alanyl-tRNA synthetase, mitochondrial; AlaRS; LOC301254; probable alanyl-tRNA synthetase, mitochondrial
Orthologs:
Homo sapiens (human) : AARS2 (alanyl-tRNA synthetase 2, mitochondrial)  HGNC  Alliance
Mus musculus (house mouse) : Aars2 (alanyl-tRNA synthetase 2, mitochondrial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aars2 (alanyl-tRNA synthetase 2, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : AARS2 (alanyl-tRNA synthetase 2, mitochondrial)
Canis lupus familiaris (dog) : AARS2 (alanyl-tRNA synthetase 2, mitochondrial)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aars2 (alanyl-tRNA synthetase 2, mitochondrial)
Sus scrofa (pig) : AARS2 (alanyl-tRNA synthetase 2, mitochondrial)
Chlorocebus sabaeus (African green monkey) : AARS2 (alanyl-tRNA synthetase 2, mitochondrial)
Heterocephalus glaber (naked mole-rat) : Aars2 (alanyl-tRNA synthetase 2, mitochondrial)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0917,869,301 - 17,881,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,869,124 - 17,880,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,755,842 - 16,769,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,085,368 - 11,096,426 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,083,044 - 11,093,739 (-)NCBI
Celera913,228,189 - 13,239,255 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:21549344  


Genomics

Comparative Map Data
Aars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0917,869,301 - 17,881,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,869,124 - 17,880,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,755,842 - 16,769,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,085,368 - 11,096,426 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,083,044 - 11,093,739 (-)NCBI
Celera913,228,189 - 13,239,255 (-)NCBICelera
Cytogenetic Map9q12NCBI
AARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl644,298,731 - 44,313,347 (-)EnsemblGRCh38hg38GRCh38
GRCh38644,297,850 - 44,313,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37644,266,463 - 44,281,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,374,441 - 44,389,041 (-)NCBINCBI36hg18NCBI36
Celera645,819,616 - 45,834,241 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef643,988,550 - 44,003,170 (-)NCBIHuRef
CHM1_1644,270,095 - 44,284,719 (-)NCBICHM1_1
Aars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,817,473 - 45,831,769 (+)NCBI
GRCm381745,503,515 - 45,520,843 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,506,841 - 45,520,843 (+)EnsemblGRCm38mm10GRCm38
MGSCv371745,643,790 - 45,657,792 (+)NCBIGRCm37mm9NCBIm37
MGSCv361744,970,422 - 44,984,424 (+)NCBImm8
Celera1748,939,666 - 48,953,555 (+)NCBICelera
Cytogenetic Map17B3NCBI
Aars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,913,867 - 9,924,886 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,915,371 - 9,924,886 (-)NCBIChiLan1.0ChiLan1.0
AARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1645,176,773 - 45,191,505 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,176,773 - 45,191,505 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0643,895,255 - 43,909,347 (-)NCBIMhudiblu_PPA_v0panPan3
AARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1212,704,983 - 12,718,821 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11212,706,043 - 12,718,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Aars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647615,772,203 - 15,784,316 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,299,460 - 39,313,778 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1739,301,020 - 39,314,296 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,170,590 - 45,183,842 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AARS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1727,855,713 - 27,870,409 (+)Ensembl
ChlSab1.11727,855,688 - 27,869,427 (+)NCBI
Aars2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475415,563,878 - 15,573,538 (+)NCBI

Position Markers
AU047834  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0917,874,005 - 17,874,140NCBIRnor6.0
Rnor_5.0916,762,840 - 16,762,975UniSTSRnor5.0
RGSC_v3.4911,089,668 - 11,089,803UniSTSRGSC3.4
Celera913,232,493 - 13,232,632UniSTS
Cytogenetic Map9q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9129467098Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9140383872Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9140383872Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9140383872Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9145029794Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9235572247355722Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9235572247355722Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9288097747375681Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9288097747880977Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9498609549986095Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9498609549986095Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9572425425692342Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)91221677157216771Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)91242546357425463Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)91242546357425463Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91555490147249201Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:132
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000031549
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 13 6 10 6 1 55 21 34 3
Low 3 19 44 35 9 35 8 10 19 14 7 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031549   ⟹   ENSRNOP00000037568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl917,869,124 - 17,880,706 (-)Ensembl
RefSeq Acc Id: NM_001106891   ⟹   NP_001100361
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,869,705 - 17,880,763 (-)NCBI
Rnor_5.0916,755,842 - 16,769,796 (-)NCBI
RGSC_v3.4911,085,368 - 11,096,426 (-)RGD
Celera913,228,189 - 13,239,255 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244513   ⟹   XP_006244575
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,869,301 - 17,881,762 (-)NCBI
Rnor_5.0916,755,842 - 16,769,796 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244515   ⟹   XP_006244577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,869,301 - 17,881,758 (-)NCBI
Rnor_5.0916,755,842 - 16,769,796 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100361 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244575 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244577 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66719 (Get FASTA)   NCBI Sequence Viewer  
  D3ZX08 (Get FASTA)   NCBI Sequence Viewer  
  EDM18733 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100361   ⟸   NM_001106891
- UniProtKB: D3ZX08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244575   ⟸   XM_006244513
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006244577   ⟸   XM_006244515
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000037568   ⟸   ENSRNOT00000031549
Protein Domains
AA_TRNA_LIGASE_II_ALA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696547
Promoter ID:EPDNEW_R7070
Type:multiple initiation site
Name:Aars2_1
Description:alanyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,880,767 - 17,880,827EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 16763900 16763901 T C snv ZFDM (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310617 AgrOrtholog
Ensembl Genes ENSRNOG00000025808 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037568 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031549 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932249 IMAGE-MGC_LOAD
InterPro Ala-tRNA-lgiase_IIc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ala-tRNA-ligase_IIc_anticod-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ala-tRNA-synth_IIc_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ala-tRNA-synth_IIc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ala_tRNA_ligase_euk/bac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301254 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188431 IMAGE-MGC_LOAD
NCBI Gene 301254 ENTREZGENE
Pfam tRNA-synt_2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aars2 PhenoGen
PRINTS TRNASYNTHALA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_II_ALA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART tRNA_SAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55186 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs alaS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.109849 ENTREZGENE
UniProt A0A0H2UHV7_RAT UniProtKB/TrEMBL
  B2RYB6_RAT UniProtKB/TrEMBL
  D3ZX08 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-07 Aars2  alanyl-tRNA synthetase 2, mitochondrial  Aars2  alanyl-tRNA synthetase 2, mitochondrial (putative)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Aars2  alanyl-tRNA synthetase 2, mitochondrial (putative)  Aars2  alanyl-tRNA synthetase 2, mitochondrial   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Aars2  alanyl-tRNA synthetase 2, mitochondrial   Aarsl_predicted  alanyl-tRNA synthetase like (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Aarsl_predicted  alanyl-tRNA synthetase like (predicted)      Symbol and Name status set to approved 70820 APPROVED