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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of dendritic spine development
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Accession:GO:0060999 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


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positive regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24328732) Alzheimers_University_of_Toronto
Ensembl		 PMID:24328732 GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G ARF1 ADP ribosylation factor 1 ISO RGD PMID:23889934 RGD:8553918 NCBI chr 2:51,219,597...51,237,640
Ensembl chr 2:51,219,667...51,237,639 		JBrowse link
G C13H21orf91 chromosome 13 C21orf91 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:182,374,587...182,409,062
Ensembl chr13:182,374,587...182,409,289 		JBrowse link
G CAMK1 calcium/calmodulin dependent protein kinase I involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:66,044,713...66,055,290
Ensembl chr13:66,044,720...66,055,295 		JBrowse link
G CDKL5 cyclin dependent kinase like 5 ISO RGD PMID:23671101 RGD:12791021 NCBI chr  X:14,858,826...15,096,969
Ensembl chr  X:14,952,225...15,078,855 		JBrowse link
G CFL1 cofilin 1 ISO RGD PMID:25723479 RGD:11570400 NCBI chr 2:6,471,558...6,475,019
Ensembl chr 2:6,469,254...6,475,035 		JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 involved_in ISO (PMID:22153079) UniProt PMID:22153079 NCBI chr14:103,675,164...103,871,245
Ensembl chr14:103,675,175...103,871,227 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:32206715 RGD:126848802 NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224 		JBrowse link
G DLG5 discs large MAGUK scaffold protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:80,249,693...80,377,496
Ensembl chr14:80,249,697...80,377,064 		JBrowse link
G EIF4G2 eukaryotic translation initiation factor 4 gamma 2 ISO RGD PMID:22514323 RGD:10755512 NCBI chr 2:48,666,590...48,678,656
Ensembl chr 2:48,666,520...48,678,950 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 involved_in ISO (PMID:18539120) UniProt PMID:18539120 NCBI chr  X:120,361,232...120,400,282
Ensembl chr  X:120,361,367...120,399,831 		JBrowse link
G FOXO6 forkhead box O6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:169,858,711...169,880,005
Ensembl chr 6:169,858,603...169,880,069 		JBrowse link
G GRN granulin precursor ISO RGD PMID:21813674 RGD:5509044 NCBI chr12:18,893,772...18,900,444
Ensembl chr12:18,893,770...18,900,446 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K ISO RGD PMID:24990929 RGD:10002784 NCBI chr10:30,975,639...30,987,955
Ensembl chr10:30,975,702...30,987,956 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:20225203 RGD:5147914 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G ITSN1 intersectin 1 ISO RGD PMID:19258322 RGD:13461864 NCBI chr13:197,301,515...197,492,537
Ensembl chr13:197,249,061...197,481,245 		JBrowse link
G LLPH LLP homolog, long-term synaptic facilitation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:30,478,545...30,485,534
Ensembl chr 5:30,474,375...30,485,057 		JBrowse link
G LPAR1 lysophosphatidic acid receptor 1 ISO RGD PMID:16638019 RGD:2317707 NCBI chr 1:251,811,583...251,979,828
Ensembl chr 1:251,811,584...251,979,159 		JBrowse link
G MAPK6 mitogen-activated protein kinase 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22508986) Ensembl
MGI		 PMID:22508986 GO_REF:0000107 NCBI chr 1:119,725,026...119,770,988
Ensembl chr 1:119,725,029...119,771,312 		JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22508986) Ensembl
MGI		 PMID:22508986 GO_REF:0000107 NCBI chr14:39,852,537...39,885,898
Ensembl chr14:39,849,413...39,886,455 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:24188180 RGD:12789443 NCBI chr  X:124,735,523...124,789,063
Ensembl chr  X:124,735,656...124,738,659 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:21683721 RGD:10040994 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:114,436,887...114,515,713
Ensembl chr14:114,437,045...114,516,721 		JBrowse link
G NLGN1 neuroligin 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15681343 GO_REF:0000107 RGD:8553420 NCBI chr13:111,851,007...112,727,202
Ensembl chr13:112,035,854...112,725,618 		JBrowse link
G NLGN3 neuroligin 3 ISO RGD PMID:15681343 RGD:8553420 NCBI chr  X:57,174,506...57,204,770
Ensembl chr  X:57,176,103...57,201,461 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:22509272 RGD:7174739 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451 		JBrowse link
G PALM paralemmin involved_in ISO (PMID:18287537) UniProt PMID:18287537 NCBI chr 2:77,619,199...77,644,561
Ensembl chr 2:77,619,199...77,644,673 		JBrowse link
G PBRM1 polybromo 1 ISO RGD PMID:31723243 RGD:150340632 NCBI chr13:34,689,718...34,821,117
Ensembl chr13:34,689,726...34,820,952 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:12052877 RGD:1299363 NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,403...74,940,362 		JBrowse link
G PSEN1 presenilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:96,478,179...96,567,884
Ensembl chr 7:96,478,190...96,569,130 		JBrowse link
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:25865668) MGI PMID:25865668 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 involved_in ISO PMID:18287537 UniProt PMID:18287537 RGD:8553517 NCBI chr 6:55,452,095...55,496,304
Ensembl chr 6:55,451,094...55,499,031 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in ISO (PMID:21795692) BHF-UCL PMID:21795692 NCBI chr 5:41,376...93,033
Ensembl chr 5:41,786...93,177 		JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD PMID:16595860 RGD:11568665 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,925...39,937,371 		JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 ISO RGD PMID:24117785 RGD:8554267 NCBI chr17:49,258,543...49,390,418
Ensembl chr17:49,258,542...49,390,399 		JBrowse link
positive regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 ISO RGD PMID:23441206 RGD:11530033 NCBI chr 3:76,691,275...76,729,269
Ensembl chr 3:76,691,280...76,729,252 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:23441206 RGD:11530033 NCBI chr15:20,104,808...20,171,721
Ensembl chr15:20,104,812...20,167,421 		JBrowse link
G AFDN afadin, adherens junction formation factor ISO RGD PMID:22948147 RGD:13838731 NCBI chr 1:1,569,652...1,698,475
Ensembl chr 1:1,570,272...1,698,694 		JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:15673667 RGD:9684988 NCBI chr12:1,609,420...1,666,965
Ensembl chr12:1,603,540...1,670,075 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta involved_in ISO PMID:12873385 UniProt PMID:12873385 RGD:8553829 NCBI chr18:50,862,225...50,956,263
Ensembl chr18:50,861,466...50,956,225 		JBrowse link
G CAPRIN1 cell cycle associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:26,830,987...26,875,425
Ensembl chr 2:26,830,267...26,875,357 		JBrowse link
G CAPRIN2 caprin family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:43,042,910...43,087,644
Ensembl chr 5:43,044,266...43,087,748 		JBrowse link
G CASK calcium/calmodulin dependent serine protein kinase ISO RGD PMID:18606847 RGD:11576294 NCBI chr  X:37,166,973...37,535,723
Ensembl chr  X:37,167,577...37,536,160 		JBrowse link
G CUX2 cut like homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:32,311,781...32,587,194
Ensembl chr14:32,311,188...32,587,203 		JBrowse link
G DBN1 drebrin 1 involved_in ISO
IEA
IBA		 RGD
Ensembl
GO_Central		 PMID:19174472 GO_REF:0000033 GO_REF:0000107 RGD:10398809 NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796 		JBrowse link
G DBNL drebrin like involved_in IBA GO_Central GO_REF:0000033 NCBI chr18:48,713,335...48,725,692
Ensembl chr18:48,713,340...48,725,697 		JBrowse link
G DHX36 DEAH-box helicase 36 involved_in ISO PMID:23651854 UniProt PMID:23651854 RGD:13792545 NCBI chr13:94,298,790...94,350,333
Ensembl chr13:94,298,794...94,350,308 		JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase ISO RGD PMID:20427644 RGD:10401235 NCBI chr 3:23,887,120...23,980,231
Ensembl chr 3:23,887,125...23,956,373 		JBrowse link
G EPHB2 EPH receptor B2 ISO RGD PMID:21364901 RGD:127285794 NCBI chr 6:80,649,098...80,849,979
Ensembl chr 6:80,650,740...80,843,567 		JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 ISO RGD PMID:19605646 RGD:7800727 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028 		JBrowse link
G GPRASP3 G protein-coupled receptor associated sorting protein family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:83,895,554...83,911,573 JBrowse link
G IL1RAPL1 interleukin 1 receptor accessory protein like 1 involved_in ISO (PMID:21940441) BHF-UCL PMID:21940441 NCBI chr  X:24,408,092...25,811,129
Ensembl chr  X:24,409,327...25,806,680 		JBrowse link
G ITPKA inositol-trisphosphate 3-kinase A acts_upstream_of_or_within ISO PMID:19890013 MGI PMID:19890013 RGD:8553536 NCBI chr 1:129,867,261...129,877,762
Ensembl chr 1:129,867,642...129,875,639 		JBrowse link
G KALRN kalirin RhoGEF kinase acts_upstream_of_or_within ISO (PMID:19625617) MGI PMID:19625617 NCBI chr13:135,653,795...136,277,072 JBrowse link
G LRP8 LDL receptor related protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:158,905,464...158,984,743
Ensembl chr 6:158,905,410...158,983,382 		JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate ISO RGD PMID:16202710 RGD:9685333 NCBI chr 1:79,789,796...79,795,895
Ensembl chr 1:79,789,815...79,795,760 		JBrowse link
G MFN1 mitofusin 1 ISO RGD PMID:19605646 RGD:7800727 NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:19605646 RGD:7800727 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO RGD PMID:19605646 RGD:7800727 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:48,567,329...48,735,836
Ensembl chr12:48,628,816...48,735,834 		JBrowse link
G PAK3 p21 (RAC1) activated kinase 3 ISO RGD PMID:18481281 RGD:7775053 NCBI chr  X:90,941,976...91,244,331
Ensembl chr  X:90,942,077...91,238,565 		JBrowse link
G PTPRD protein tyrosine phosphatase receptor type D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:211,832,409...214,013,013
Ensembl chr 1:213,483,348...214,009,893 		JBrowse link
G RELN reelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,863...103,963,883 		JBrowse link
G SLC30A1 solute carrier family 30 member 1 ISO RGD PMID:25319628 RGD:11057402 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672 		JBrowse link
G STAU2 staufen double-stranded RNA binding protein 2 ISO RGD PMID:16418534 RGD:10043163 NCBI chr 4:62,139,456...62,455,509
Ensembl chr 4:62,139,464...62,455,499 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 ISO RGD PMID:16474385 RGD:10043325 NCBI chr13:194,774,495...195,235,750
Ensembl chr13:194,774,497...195,005,089 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17668
    developmental process 6687
      positive regulation of developmental process 1512
        positive regulation of dendritic spine development 66
          positive regulation of dendritic spine morphogenesis 31
Path 2
Term Annotations click to browse term
  biological_process 17668
    developmental process 6687
      anatomical structure development 6284
        multicellular organism development 5080
          system development 4427
            nervous system development 2770
              neurogenesis 2057
                generation of neurons 1764
                  neuron differentiation 1681
                    neuron development 1380
                      neuron projection development 1210
                        dendrite development 331
                          dendritic spine development 136
                            regulation of dendritic spine development 86
                              positive regulation of dendritic spine development 66
                                positive regulation of dendritic spine morphogenesis 31
paths to the root