ACTR3 (actin related protein 3) - Rat Genome Database

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Gene: ACTR3 (actin related protein 3) Sus scrofa
Analyze
Symbol: ACTR3
Name: actin related protein 3
RGD ID: 13854198
Description: ENCODES a protein that exhibits actin binding (ortholog); ATPase binding (ortholog); INVOLVED IN astrocyte differentiation (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Cognitive Dysfunction (ortholog); colorectal carcinoma (ortholog); FOUND IN actin filament (ortholog); apical ectoplasmic specialization (ortholog); apical tubulobulbar complex (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-related protein 3; ARP3; ARP3 actin related protein 3 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1520,104,812 - 20,167,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21522,725,584 - 22,786,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
Arp2/3 complex-mediated actin nucleation  (IBA,IEA)
astrocyte differentiation  (ISO)
asymmetric cell division  (IEA)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to pyrimidine ribonucleotide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to triterpenoid  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (IEA)
cilium assembly  (IEA)
establishment or maintenance of cell polarity  (IEA)
meiotic cell cycle  (IEA)
meiotic chromosome movement towards spindle pole  (IEA)
meiotic cytokinesis  (IEA)
negative regulation of axon extension  (ISO)
negative regulation of bleb assembly  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of dendrite morphogenesis  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
postsynapse organization  (ISO)
postsynaptic actin cytoskeleton organization  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of myosin II filament organization  (ISO)
response to estradiol  (ISO)
response to heparin  (ISO)
Sertoli cell barrier remodeling  (ISO)
spermatogenesis  (ISO)
spindle localization  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:30032202  


Genomics

Comparative Map Data
ACTR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1520,104,812 - 20,167,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21522,725,584 - 22,786,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,889,934 - 113,962,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,890,063 - 113,962,596 (+)EnsemblGRCh38hg38GRCh38
GRCh372114,647,511 - 114,720,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,364,007 - 114,432,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342114,363,766 - 114,432,397NCBI
Celera2107,963,979 - 108,036,693 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,964,108 - 107,039,652 (+)NCBIHuRef
CHM1_12114,651,066 - 114,722,668 (+)NCBICHM1_1
T2T-CHM13v2.02114,314,590 - 114,387,240 (+)NCBIT2T-CHM13v2.0
Actr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391125,320,642 - 125,363,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1125,320,642 - 125,363,464 (-)EnsemblGRCm39 Ensembl
GRCm381125,392,905 - 125,435,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1125,392,905 - 125,435,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371127,289,483 - 127,332,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361127,220,452 - 127,263,036 (-)NCBIMGSCv36mm8
Celera1128,040,526 - 128,085,756 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map154.7NCBI
Actr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81339,353,413 - 39,396,509 (-)NCBIGRCr8
mRatBN7.21336,800,739 - 36,843,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1336,800,093 - 36,844,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1339,401,982 - 39,443,515 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01340,689,982 - 40,731,516 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01337,949,578 - 37,992,708 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01341,695,520 - 41,738,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1341,695,183 - 41,738,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01346,808,187 - 46,850,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41337,861,558 - 37,904,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11337,876,286 - 37,879,398 (-)NCBI
Celera1336,607,886 - 36,650,420 (-)NCBICelera
Cytogenetic Map13q12NCBI
Actr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545915,216,914 - 15,284,013 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545915,216,914 - 15,284,013 (-)NCBIChiLan1.0ChiLan1.0
ACTR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21315,875,990 - 15,952,268 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B15,893,498 - 15,967,239 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B827,184 - 900,424 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B114,373,392 - 114,445,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B114,373,392 - 114,445,729 (+)Ensemblpanpan1.1panPan2
ACTR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11935,097,968 - 35,133,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1935,098,639 - 35,169,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1935,329,635 - 35,387,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01936,533,033 - 36,590,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1936,533,040 - 36,591,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11935,181,031 - 35,238,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01935,342,002 - 35,399,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01936,561,512 - 36,619,469 (-)NCBIUU_Cfam_GSD_1.0
Actr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530385,918,173 - 85,977,081 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646955,639,068 - 55,699,640 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646955,639,345 - 55,699,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11016,296,350 - 16,369,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1016,297,502 - 16,369,220 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660616,176,980 - 6,250,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473231,361,147 - 31,427,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473231,360,804 - 31,427,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACTR3
1702 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000017110   ⟹   ENSSSCP00000016650
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,105,045 - 20,167,097 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000038794   ⟹   ENSSSCP00000031356
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,125,888 - 20,166,424 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000043395   ⟹   ENSSSCP00000033638
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,125,888 - 20,166,415 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000053589   ⟹   ENSSSCP00000058908
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,104,812 - 20,161,989 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000090441   ⟹   ENSSSCP00000063037
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,104,846 - 20,137,487 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000100546   ⟹   ENSSSCP00000075643
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,126,248 - 20,167,421 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000104875   ⟹   ENSSSCP00000081009
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,125,888 - 20,166,305 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000106304   ⟹   ENSSSCP00000077658
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1520,129,449 - 20,162,257 (+)Ensembl
RefSeq Acc Id: NM_001134343   ⟹   NP_001127815
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11520,105,161 - 20,166,305 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339000
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11520,104,808 - 20,171,721 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001127815   ⟸   NM_001134343
- UniProtKB: B5APU4 (UniProtKB/TrEMBL),   A0A8D1QE84 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000063037   ⟸   ENSSSCT00000090441
Ensembl Acc Id: ENSSSCP00000016650   ⟸   ENSSSCT00000017110
Ensembl Acc Id: ENSSSCP00000058908   ⟸   ENSSSCT00000053589
Ensembl Acc Id: ENSSSCP00000031356   ⟸   ENSSSCT00000038794
Ensembl Acc Id: ENSSSCP00000033638   ⟸   ENSSSCT00000043395
Ensembl Acc Id: ENSSSCP00000081009   ⟸   ENSSSCT00000104875
Ensembl Acc Id: ENSSSCP00000075643   ⟸   ENSSSCT00000100546
Ensembl Acc Id: ENSSSCP00000077658   ⟸   ENSSSCT00000106304


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015710 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00055012528 UniProtKB/TrEMBL
  ENSSSCG00060044702 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017110.4 UniProtKB/TrEMBL
  ENSSSCT00000038794 ENTREZGENE
  ENSSSCT00000038794.3 UniProtKB/TrEMBL
  ENSSSCT00000043395.3 UniProtKB/TrEMBL
  ENSSSCT00000053589.3 UniProtKB/TrEMBL
  ENSSSCT00000100546 ENTREZGENE
  ENSSSCT00000100546.1 UniProtKB/TrEMBL
  ENSSSCT00000104875.1 UniProtKB/TrEMBL
  ENSSSCT00000106304.1 UniProtKB/TrEMBL
  ENSSSCT00055025050.1 UniProtKB/TrEMBL
  ENSSSCT00060060758.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Actin, Chain A, domain 2 UniProtKB/TrEMBL
  Actin, Chain A, domain 4 UniProtKB/TrEMBL
InterPro Actin UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report ssc:396738 UniProtKB/TrEMBL
NCBI Gene ACTR3 ENTREZGENE
PANTHER PTHR11937 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PROSITE ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A286ZIH7_PIG UniProtKB/TrEMBL
  A0A286ZQ99_PIG UniProtKB/TrEMBL
  A0A287BS06_PIG UniProtKB/TrEMBL
  A0A8D1QE84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F9Y0_PIG UniProtKB/TrEMBL
  A0A8W4FFL3_PIG UniProtKB/TrEMBL
  A0A8W4FPX4_PIG UniProtKB/TrEMBL
  B5APU4 ENTREZGENE, UniProtKB/TrEMBL
  F2Z5D2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:103894 ENTREZGENE