OPA1 (OPA1 mitochondrial dynamin like GTPase) - Rat Genome Database
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Gene: OPA1 (OPA1 mitochondrial dynamin like GTPase) Sus scrofa
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Symbol: OPA1
Name: OPA1 mitochondrial dynamin like GTPase
RGD ID: 14297845
Description: ENCODES a protein that exhibits kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aging (ortholog); calcium import into the mitochondrion (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN mitochondria fusion pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); Behr syndrome (ortholog); FOUND IN extrinsic component of mitochondrial inner membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH cyclosporin A; deoxynivalenol; vitamin E
Type: protein-coding
RefSeq Status: MODEL
Also known as: dynamin-like 120 kDa protein, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13130,624,823 - 130,719,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113130,624,771 - 130,718,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,148,025 - 140,230,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
apoptotic process  (IEA)
calcium import into the mitochondrion  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to L-glutamate  (ISO)
cellular senescence  (IEA)
cochlea development  (ISO)
dynamin family protein polymerization involved in mitochondrial fission  (IBA)
GTP metabolic process  (IEA)
inner mitochondrial membrane organization  (IEA)
intracellular distribution of mitochondria  (ISO)
membrane fusion  (IBA)
membrane tubulation  (IEA)
mitochondrial fission  (IBA)
mitochondrial fusion  (IEA)
mitochondrial genome maintenance  (IEA)
mitochondrion morphogenesis  (ISO)
mitochondrion organization  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA)
neural tube closure  (IEA)
organelle fission  (IBA)
positive regulation of cellular response to insulin stimulus  (ISO)
positive regulation of dendrite development  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of mitochondrial fusion  (ISO)
positive regulation of neuron maturation  (ISO)
protein complex oligomerization  (IEA)
response to curcumin  (ISO)
response to electrical stimulus  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
retina development in camera-type eye  (ISO)
visual perception  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
OPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13130,624,823 - 130,719,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113130,624,771 - 130,718,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,148,025 - 140,230,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3193,593,144 - 193,697,811 (+)EnsemblGRCh38hg38GRCh38
GRCh383193,593,149 - 193,697,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373193,310,933 - 193,415,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363194,793,806 - 194,898,009 (+)NCBINCBI36hg18NCBI36
Build 343194,793,813 - 194,898,017NCBI
Celera3191,726,124 - 191,830,778 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3190,698,074 - 190,803,338 (+)NCBIHuRef
CHM1_13193,273,732 - 193,378,486 (+)NCBICHM1_1
Opa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,398,099 - 29,481,924 (+)NCBIGRCm39mm39
GRCm381629,579,281 - 29,663,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1629,579,334 - 29,654,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv371629,579,428 - 29,652,576 (+)NCBIGRCm37mm9NCBIm37
MGSCv361629,499,089 - 29,572,237 (+)NCBImm8
Celera1630,084,446 - 30,156,121 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1620.65NCBI
Opa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Celera1170,077,956 - 70,151,932 (-)NCBICelera
Cytogenetic Map11q22NCBI
Opa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,927,490 - 15,007,082 (-)NCBIChiLan1.0ChiLan1.0
OPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13201,207,609 - 201,312,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,207,607 - 201,312,358 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03190,890,242 - 190,995,133 (+)NCBIMhudiblu_PPA_v0panPan3
OPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2352,068,118 - 52,151,593 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12352,068,123 - 52,154,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Opa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367111,027,531 - 1,113,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1587,679,077 - 87,779,102 (+)Ensembl
ChlSab1.11587,679,656 - 87,778,767 (+)NCBI
Opa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473063,911,066 - 63,994,886 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 3 3 5 2 23 2 2 3
Low 2 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012934   ⟹   ENSSSCP00000012593
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,624,832 - 130,717,986 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045045   ⟹   ENSSSCP00000032255
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,624,832 - 130,719,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000052175   ⟹   ENSSSCP00000040877
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,624,832 - 130,719,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071202   ⟹   ENSSSCP00000070261
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,629,867 - 130,697,467 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077973   ⟹   ENSSSCP00000063843
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,629,867 - 130,697,467 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085946   ⟹   ENSSSCP00000060068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,624,823 - 130,697,432 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000086142   ⟹   ENSSSCP00000066387
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13130,625,137 - 130,716,457 (+)Ensembl
RefSeq Acc Id: XM_021070063   ⟹   XP_020925722
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113130,624,779 - 130,718,345 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021070064   ⟹   XP_020925723
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113130,624,771 - 130,718,345 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021070065   ⟹   XP_020925724
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113130,624,779 - 130,718,345 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021070066   ⟹   XP_020925725
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113130,624,774 - 130,718,345 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020925722 (Get FASTA)   NCBI Sequence Viewer  
  XP_020925723 (Get FASTA)   NCBI Sequence Viewer  
  XP_020925724 (Get FASTA)   NCBI Sequence Viewer  
  XP_020925725 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020925723   ⟸   XM_021070064
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020925725   ⟸   XM_021070066
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020925722   ⟸   XM_021070063
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020925724   ⟸   XM_021070065
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000032255   ⟸   ENSSSCT00000045045
RefSeq Acc Id: ENSSSCP00000040877   ⟸   ENSSSCT00000052175
RefSeq Acc Id: ENSSSCP00000066387   ⟸   ENSSSCT00000086142
RefSeq Acc Id: ENSSSCP00000070261   ⟸   ENSSSCT00000071202
RefSeq Acc Id: ENSSSCP00000012593   ⟸   ENSSSCT00000012934
RefSeq Acc Id: ENSSSCP00000060068   ⟸   ENSSSCT00000085946
RefSeq Acc Id: ENSSSCP00000063843   ⟸   ENSSSCT00000077973
Protein Domains
Dynamin-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011822 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014631 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000012593 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000032255 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000040877 UniProtKB/TrEMBL
  ENSSSCP00000060068 UniProtKB/TrEMBL
  ENSSSCP00000063843 UniProtKB/TrEMBL
  ENSSSCP00000066387 UniProtKB/TrEMBL
  ENSSSCP00000070261 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070024352 UniProtKB/TrEMBL
  ENSSSCP00070024362 UniProtKB/TrEMBL
  ENSSSCP00070024380 UniProtKB/TrEMBL
  ENSSSCP00070024386 UniProtKB/TrEMBL
  ENSSSCP00070024394 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012934 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045045 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000052175 UniProtKB/TrEMBL
  ENSSSCT00000071202 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000077973 UniProtKB/TrEMBL
  ENSSSCT00000085946 UniProtKB/TrEMBL
  ENSSSCT00000086142 UniProtKB/TrEMBL
  ENSSSCT00070029219 UniProtKB/TrEMBL
  ENSSSCT00070029232 UniProtKB/TrEMBL
  ENSSSCT00070029255 UniProtKB/TrEMBL
  ENSSSCT00070029262 UniProtKB/TrEMBL
  ENSSSCT00070029271 UniProtKB/TrEMBL
InterPro Dynamin_GTPase UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  Opa1 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene OPA1 ENTREZGENE
PANTHER PTHR11566 UniProtKB/TrEMBL
  PTHR11566:SF67 UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/TrEMBL
PRINTS DYNAMIN UniProtKB/TrEMBL
PROSITE G_DYNAMIN_2 UniProtKB/TrEMBL
SMART DYNc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniGene Ssc.34434 ENTREZGENE
UniProt A0A286ZLB3_PIG UniProtKB/TrEMBL
  A0A287AAF5_PIG UniProtKB/TrEMBL
  A0A4X1U3X3_PIG UniProtKB/TrEMBL
  A0A4X1U890_PIG UniProtKB/TrEMBL
  A0A4X1U8A3_PIG UniProtKB/TrEMBL
  A0A4X1U8X7_PIG UniProtKB/TrEMBL
  A0A4X1U938_PIG UniProtKB/TrEMBL
  A0A5G2Q9R6_PIG UniProtKB/TrEMBL
  A0A5G2QP34_PIG UniProtKB/TrEMBL
  A0A5G2QQR2_PIG UniProtKB/TrEMBL
  A0A5G2QZE5_PIG UniProtKB/TrEMBL
  F1SFG7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91045 ENTREZGENE