MECP2 (methyl-CpG binding protein 2) - Rat Genome Database

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Gene: MECP2 (methyl-CpG binding protein 2) Sus scrofa
Analyze
Symbol: MECP2
Name: methyl-CpG binding protein 2
RGD ID: 14291696
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); double-stranded methylated DNA binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); behavioral fear response (ortholog); biogenic amine metabolic process (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); Angelman syndrome (ortholog); Animal Disease Models (ortholog); FOUND IN chromatin (ortholog); glutamatergic synapse (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyl CpG binding protein 2 (Rett syndrome); methyl-CpG-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,735,656 - 124,738,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,295,001 - 142,349,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Angelman syndrome  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal hemophilia A  (ISO)
Barth syndrome  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
Chromosome Xq28 Duplication Syndrome  (ISO)
Cocaine-Related Disorders  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 2  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
dyskeratosis congenita  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
epilepsy  (ISO)
Facial Hypertrichosis  (ISO)
factor VIII deficiency  (ISO)
favism  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
focal epilepsy  (ISO)
frontometaphyseal dysplasia  (ISO)
gastrointestinal system disease  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
immunodeficiency 33  (ISO)
intellectual disability  (ISO)
Juberg Hayward Syndrome  (ISO)
learning disability  (ISO)
Melnick-Needles syndrome  (ISO)
methylmalonic acidemia and homocysteinemia cblX type  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Muscle Hypotonia  (ISO)
Myoclonus  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
non-syndromic X-linked intellectual disability  (ISO)
otopalatodigital syndrome type 2  (ISO)
paraplegia  (ISO)
periventricular nodular heterotopia  (ISO)
Periventricular Nodular Heterotopia 4  (ISO)
pervasive developmental disorder  (ISO)
Psychomotor Disorders  (ISO)
pulmonary fibrosis  (ISO)
respiratory failure  (ISO)
Rett syndrome  (ISO)
Rett Syndrome, Atypical  (ISO)
Rett Syndrome, Zappella Variant  (ISO)
schizophrenia  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Smith-Magenis syndrome  (ISO)
Splenomegaly  (ISO)
stereotypic movement disorder  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
transient cerebral ischemia  (ISO)
visual epilepsy  (ISO)
X-Linked Intellectual Developmental Disorders  (ISO)
X-linked intellectual disability-psychosis-macroorchidism syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IEA,ISO)
associative learning  (IEA)
behavioral fear response  (IEA,ISO)
biogenic amine metabolic process  (IEA,ISO)
brain development  (IEA,ISO)
cardiolipin metabolic process  (IEA,ISO)
catecholamine secretion  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to potassium ion  (ISO)
cerebellum development  (IEA,ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IEA,ISO)
dendrite development  (IEA,ISO)
epigenetic regulation of gene expression  (IEA,ISO)
excitatory postsynaptic potential  (IEA,ISO)
gene expression  (IEA)
genomic imprinting  (IEA,ISO)
glial cell proliferation  (IEA,ISO)
glucocorticoid metabolic process  (IEA,ISO)
glutamine metabolic process  (IEA,ISO)
heterochromatin formation  (IEA,ISO)
hippocampus development  (ISO)
inositol metabolic process  (IEA,ISO)
learning  (IEA,ISO)
long-term memory  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung alveolus development  (ISO)
memory  (IEA,ISO)
multicellular organismal response to stress  (IEA,ISO)
negative regulation of angiogenesis  (IEA)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of gene expression via chromosomal CpG island methylation  (IEA)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of primary miRNA processing  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of respiratory gaseous exchange  (ISO)
negative regulation of smooth muscle cell differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (IEA,ISO)
neuromuscular process  (IEA,ISO)
neuromuscular process controlling posture  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuron maturation  (IEA,ISO)
neuron projection development  (IEA,ISO)
Notch signaling pathway  (IEA)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
phosphatidylcholine metabolic process  (IEA,ISO)
positive regulation of anterograde dense core granule transport  (ISO)
positive regulation of branching morphogenesis of a nerve  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IEA,ISO)
positive regulation of microtubule nucleation  (IEA)
positive regulation of retrograde dense core granule transport  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
post-embryonic development  (IEA,ISO)
principal sensory nucleus of trigeminal nerve development  (ISO)
proprioception  (IEA,ISO)
protein localization  (IEA,ISO)
regulation of action potential firing threshold  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of respiratory gaseous exchange by nervous system process  (IEA,ISO)
regulation of synapse organization  (ISO)
regulation of synaptic plasticity  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to alcohol  (ISO)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to hypoxia  (IEA,ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to organic cyclic compound  (ISO)
response to other organism  (IEA,ISO)
sensory perception of pain  (IEA,ISO)
social behavior  (IEA,ISO)
spinal cord development  (ISO)
startle response  (IEA,ISO)
striatum development  (ISO)
synapse assembly  (IEA,ISO)
thalamus development  (ISO)
trans-synaptic signaling by BDNF  (IEA,ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular system development  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MECP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,735,656 - 124,738,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,295,001 - 142,349,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MECP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,021,573 - 154,097,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,287,024 - 153,363,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
T2T-CHM13v2.0X152,295,254 - 152,371,375 (-)NCBIT2T-CHM13v2.0
Mecp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,070,198 - 73,129,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,070,198 - 73,129,296 (-)EnsemblGRCm39 Ensembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,026,592 - 74,135,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBIMGSCv36mm8
CeleraX65,279,211 - 65,338,021 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.63NCBI
Mecp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,932,481 - 156,995,981 (-)NCBIGRCr8
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,931,091 - 153,985,757 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,494,308 - 157,548,973 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,166,123 - 155,220,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
Mecp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580679,109 - 735,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBIChiLan1.0ChiLan1.0
MECP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,061,838 - 154,137,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,065,444 - 154,140,771 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,571,864 - 143,647,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,458,248 - 153,527,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,465,204 - 153,527,854 (-)Ensemblpanpan1.1panPan2
MECP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,866,721 - 121,876,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBIUU_Cfam_GSD_1.0
Mecp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,165,167 - 119,228,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809911,764 - 966,839 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809902,938 - 967,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MECP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,445,028 - 128,519,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,453,577 - 128,455,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,318,831 - 66,395,535 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mecp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946628,284 - 685,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946620,581 - 685,339 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MECP2
650 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000013989   ⟹   ENSSSCP00000013606
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX124,735,656 - 124,738,141 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000077209   ⟹   ENSSSCP00000061907
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX124,735,656 - 124,738,659 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000087920   ⟹   ENSSSCP00000073717
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX124,736,574 - 124,737,941 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000090595   ⟹   ENSSSCP00000062824
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX124,735,656 - 124,789,110 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000090669   ⟹   ENSSSCP00000070124
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX124,736,106 - 124,737,941 (-)Ensembl
RefSeq Acc Id: XM_021080802   ⟹   XP_020936461
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020936461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000013606.6
  ENSSSCP00000061907.2
  ENSSSCP00000070124.2
  ENSSSCP00000073717.2
  ENSSSCP00050040543.1
RefSeq Acc Id: XP_020936461   ⟸   XM_021080802
- UniProtKB: A0A8D1NND6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000062824   ⟸   ENSSSCT00000090595
Ensembl Acc Id: ENSSSCP00000070124   ⟸   ENSSSCT00000090669
Ensembl Acc Id: ENSSSCP00000061907   ⟸   ENSSSCT00000077209
Ensembl Acc Id: ENSSSCP00000073717   ⟸   ENSSSCT00000087920
Ensembl Acc Id: ENSSSCP00000013606   ⟸   ENSSSCT00000013989
Protein Domains
MBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034742 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00050068856 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013989.6 UniProtKB/TrEMBL
  ENSSSCT00000077209.2 UniProtKB/TrEMBL
  ENSSSCT00000087920.2 UniProtKB/TrEMBL
  ENSSSCT00000090669.2 UniProtKB/TrEMBL
  ENSSSCT00050093979.1 UniProtKB/TrEMBL
InterPro DNA-bd_dom_sf UniProtKB/TrEMBL
  Me_CpG-bd_MeCP2 UniProtKB/TrEMBL
  MeCP2/MBD4 UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/TrEMBL
NCBI Gene MECP2 ENTREZGENE
PANTHER METHYL-CPG-BINDING PROTEIN 2 UniProtKB/TrEMBL
  PTHR15074 UniProtKB/TrEMBL
Pfam MBD UniProtKB/TrEMBL
PIRSF Methyl_CpG_bd_MeCP2 UniProtKB/TrEMBL
PROSITE MBD UniProtKB/TrEMBL
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP SSF54171 UniProtKB/TrEMBL
UniProt A0A5G2QE26_PIG UniProtKB/TrEMBL
  A0A5G2RFS3_PIG UniProtKB/TrEMBL
  A0A5G2RG52_PIG UniProtKB/TrEMBL
  A0A8D1NND6 ENTREZGENE, UniProtKB/TrEMBL
  F1RZT9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90101 ENTREZGENE