FGD4 (FYVE, RhoGEF and PH domain containing 4) - Rat Genome Database

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Gene: FGD4 (FYVE, RhoGEF and PH domain containing 4) Sus scrofa
Analyze
Symbol: FGD4
Name: FYVE, RhoGEF and PH domain containing 4
RGD ID: 13936768
Description: ENCODES a protein that exhibits BH2 domain binding (ortholog); clathrin binding (ortholog); GTP-dependent protein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); cellular response to lipid (ortholog); cellular response to oxygen-glucose deprivation (ortholog); PARTICIPATES IN mitochondria fission pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); Charcot-Marie-Tooth disease type 4 (ortholog); FOUND IN brush border (ortholog); clathrin coat of trans-Golgi network vesicle (ortholog); clathrin-coated pit (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; cyclosporin A
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNM1L; dynamin 1 like; dynamin-1-like protein; dynamin-1-like protein-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1541,571,054 - 41,636,058 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,756,967 - 44,785,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (ISO)
cellular response to lipid  (ISO)
cellular response to oxygen-glucose deprivation  (ISO)
cellular response to thapsigargin  (ISO)
dynamin family protein polymerization involved in mitochondrial fission  (ISO)
endocytosis  (IEA)
endoplasmic reticulum organization  (ISO)
heart contraction  (ISO)
intracellular distribution of mitochondria  (ISO)
membrane fusion  (ISO)
mitochondrial fission  (IEA,ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrial membrane fission  (ISO)
mitochondrion morphogenesis  (ISO)
mitochondrion organization  (ISO)
necroptotic process  (ISO)
negative regulation of mitochondrial fusion  (ISO)
peroxisome fission  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of synaptic vesicle exocytosis  (ISO)
protein complex oligomerization  (ISO)
protein localization to mitochondrion  (ISO)
protein-containing complex assembly  (ISO)
regulation of ATP metabolic process  (ISO)
regulation of autophagy of mitochondrion  (ISO)
regulation of catalytic activity  (IEA)
regulation of gene expression  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of peroxisome organization  (ISO)
regulation of ubiquitin protein ligase activity  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to flavonoid  (ISO)
response to hypobaric hypoxia  (ISO)
rhythmic process  (IEA)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle recycling via endosome  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
FGD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1541,571,054 - 41,636,058 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,756,967 - 44,785,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1232,679,200 - 32,745,650 (+)EnsemblGRCh38hg38GRCh38
GRCh381232,679,296 - 32,745,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371232,832,235 - 32,898,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,723,491 - 32,788,621 (+)NCBINCBI36hg18NCBI36
Build 341232,723,490 - 32,787,810NCBI
Celera1212,653,086 - 12,719,281 (+)NCBI
Cytogenetic Map12p11.21NCBI
HuRef1232,584,423 - 32,651,060 (+)NCBIHuRef
CHM1_11232,798,646 - 32,865,086 (+)NCBICHM1_1
Dnm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,130,092 - 16,176,902 (-)NCBIGRCm39mm39
GRCm39 Ensembl1616,130,094 - 16,176,823 (-)Ensembl
GRCm381616,312,228 - 16,359,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,312,230 - 16,358,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371616,312,326 - 16,359,123 (-)NCBIGRCm37mm9NCBIm37
MGSCv361616,225,811 - 16,272,608 (-)NCBImm8
Celera1616,883,274 - 16,930,064 (-)NCBICelera
Cytogenetic Map16A2NCBI
Dnm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21184,581,216 - 84,632,382 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1184,581,216 - 84,631,482 (+)Ensembl
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
Dnm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBIChiLan1.0ChiLan1.0
DNM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11256,077,504 - 56,142,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,077,504 - 56,142,376 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01253,476,553 - 53,541,421 (-)NCBIMhudiblu_PPA_v0panPan3
DNM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,161,855 - 16,211,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,163,357 - 16,211,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2730,213,206 - 30,264,757 (+)NCBI
ROS_Cfam_1.02716,342,630 - 16,394,291 (-)NCBI
UMICH_Zoey_3.12716,151,140 - 16,202,287 (-)NCBI
UNSW_CanFamBas_1.02716,183,766 - 16,235,121 (-)NCBI
UU_Cfam_GSD_1.02730,361,257 - 30,412,627 (+)NCBI
Dnm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,743,024 - 76,799,054 (-)NCBI
SpeTri2.0NW_0049366073,576,357 - 3,632,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,114,642 - 32,178,330 (+)NCBI
ChlSab1.1 Ensembl1132,114,675 - 32,177,661 (+)Ensembl
Vero_WHO_p1.0NW_0236660692,716,938 - 2,783,519 (-)NCBI
Dnm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 1 4 19 2 3 3
Low 2 2 2 1 2 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: XM_021092056   ⟹   XP_020947715
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092057   ⟹   XP_020947716
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092058   ⟹   XP_020947717
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092060   ⟹   XP_020947719
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,058 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092061   ⟹   XP_020947720
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092062   ⟹   XP_020947721
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092063   ⟹   XP_020947722
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092064   ⟹   XP_020947723
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1541,571,054 - 41,636,042 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020947719   ⟸   XM_021092060
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020947720   ⟸   XM_021092061
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020947716   ⟸   XM_021092057
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020947715   ⟸   XM_021092056
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020947723   ⟸   XM_021092064
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020947722   ⟸   XM_021092063
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020947717   ⟸   XM_021092058
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020947721   ⟸   XM_021092062
- Peptide Label: isoform X6
- Sequence:
Protein Domains
DH   Dynamin-type G   FYVE-type   GED   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000530 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026228 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000030301 UniProtKB/TrEMBL
  ENSSSCP00000041362 UniProtKB/TrEMBL
  ENSSSCP00000049804 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000052678 UniProtKB/TrEMBL
  ENSSSCP00000057851 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070045257 UniProtKB/TrEMBL
  ENSSSCP00070045329 UniProtKB/TrEMBL
  ENSSSCP00070045394 UniProtKB/TrEMBL
  ENSSSCP00070045405 UniProtKB/TrEMBL
  ENSSSCP00070045414 UniProtKB/TrEMBL
  ENSSSCP00070045421 UniProtKB/TrEMBL
  ENSSSCP00070045440 UniProtKB/TrEMBL
  ENSSSCP00070045452 UniProtKB/TrEMBL
  ENSSSCP00070045466 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033918 UniProtKB/TrEMBL
  ENSSSCT00000051863 UniProtKB/TrEMBL
  ENSSSCT00000054204 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000062556 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000064276 UniProtKB/TrEMBL
  ENSSSCT00070053407 UniProtKB/TrEMBL
  ENSSSCT00070053484 UniProtKB/TrEMBL
  ENSSSCT00070053549 UniProtKB/TrEMBL
  ENSSSCT00070053562 UniProtKB/TrEMBL
  ENSSSCT00070053571 UniProtKB/TrEMBL
  ENSSSCT00070053581 UniProtKB/TrEMBL
  ENSSSCT00070053604 UniProtKB/TrEMBL
  ENSSSCT00070053618 UniProtKB/TrEMBL
  ENSSSCT00070053632 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  DNM1L UniProtKB/TrEMBL
  Dynamin_central UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/TrEMBL
  FDG4_N_PH UniProtKB/TrEMBL
  FGD1-4_PH2 UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  GED_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene DNM1L ENTREZGENE
PANTHER PTHR11566 UniProtKB/TrEMBL
  PTHR11566:SF39 UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  FYVE UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PRINTS DYNAMIN UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  G_DYNAMIN_1 UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART DYNc UniProtKB/TrEMBL
  FYVE UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF48065 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A287AC26_PIG UniProtKB/TrEMBL
  A0A287B0Q6_PIG UniProtKB/TrEMBL
  A0A287B878_PIG UniProtKB/TrEMBL
  A0A287BMW9_PIG UniProtKB/TrEMBL
  A0A4X1VPA8_PIG UniProtKB/TrEMBL
  A0A4X1VPD5_PIG UniProtKB/TrEMBL
  A0A4X1VTU1_PIG UniProtKB/TrEMBL
  A0A4X1VTW4_PIG UniProtKB/TrEMBL
  A0A4X1VTZ3_PIG UniProtKB/TrEMBL
  A0A4X1VUC4_PIG UniProtKB/TrEMBL
  A0A4X1VUX6_PIG UniProtKB/TrEMBL
  A0A4X1VVX2_PIG UniProtKB/TrEMBL
  K7GQX7_PIG UniProtKB/TrEMBL
UniProt Secondary F1SGD1 UniProtKB/TrEMBL
  K7GRZ1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-26 FGD4  FYVE, RhoGEF and PH domain containing 4  DNM1L  dynamin 1 like  Symbol and/or name change 19259463 PROVISIONAL