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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of JNK cascade
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Accession:GO:0046329 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
Synonyms:exact_synonym: down regulation of JNK cascade;   downregulation of JNK cascade
 narrow_synonym: inhibition of JNK cascade


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negative regulation of JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated involved_in ISO UniProtKB:O35625 (PMID:17681137) RGD PMID:17681137 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA RGD PMID:17064355 RGD:2298577 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO
ISS
IBA		 (PMID:29291351)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:29291351 GO_REF:0000024 GO_REF:0000033 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 involved_in ISO
IBA		 (PMID:17197390)
GO_REF:0000033		 RGD
GO_Central		 PMID:17197390 GO_REF:0000033 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:10391943)
MGI:3052343 (PMID:15306813)
GO_REF:0000033		 RGD
GO_Central		 PMID:10391943 PMID:15306813 GO_REF:0000033 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (PMID:11959862) RGD PMID:11959862 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO
IBA		 (PMID:11085983), (PMID:19010898)
GO_REF:0000033		 RGD
GO_Central		 PMID:11085983 PMID:19010898 GO_REF:0000033 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Fktn fukutin involved_in ISO (PMID:18808525) RGD PMID:18808525 NCBI chr 5:68,339,803...68,396,412
Ensembl chr 5:68,340,028...68,396,409 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (PMID:11931768)
(PMID:22424771)		 RGD PMID:11931768 PMID:22424771 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650 		JBrowse link
G Hdac3 histone deacetylase 3 involved_in ISO (PMID:11931768) RGD PMID:11931768 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase involved_in ISO (PMID:18246070) RGD PMID:18246070 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Klhl31 kelch-like family member 31 involved_in ISO
IBA		 (PMID:18719355)
GO_REF:0000033		 RGD
GO_Central		 PMID:18719355 GO_REF:0000033 NCBI chr 8:78,515,514...78,538,873
Ensembl chr 8:78,515,514...78,538,873 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP RGD PMID:12064607 RGD:1299562 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Marveld3 MARVEL domain containing 3 acts_upstream_of_or_within ISO (PMID:24567356) RGD PMID:24567356 NCBI chr19:37,908,727...37,923,420
Ensembl chr19:37,905,638...37,923,420 		JBrowse link
G Mecom MDS1 and EVI1 complex locus involved_in ISO (PMID:10856240) RGD PMID:10856240 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Men1 menin 1 involved_in ISO
IEA		 (PMID:12226747)
GO_REF:0000107		 RGD
Ensembl		 PMID:12226747 GO_REF:0000107 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 involved_in ISO
IEA		 (PMID:11931768)
GO_REF:0000107		 RGD
Ensembl		 PMID:11931768 GO_REF:0000107 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 acts_upstream_of_or_within ISO MGI:1100089 (PMID:22073305) RGD PMID:22073305 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
G Per1 period circadian regulator 1 involved_in IMP PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in ISO
ISS		 (PMID:22095282)
GO_REF:0000024		 RGD
UniProt		 PMID:22095282 GO_REF:0000024 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 IDA RGD PMID:18567805 RGD:4107045 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in IMP PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr18:34,045,715...34,148,342
Ensembl chr18:34,046,879...34,146,856 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (PMID:17954568) RGD PMID:17954568 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Taok3 TAO kinase 3 involved_in ISO
IEA		 (PMID:10559204)
GO_REF:0000107		 RGD
Ensembl		 PMID:10559204 GO_REF:0000107 NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 involved_in ISO (PMID:20732415) RGD PMID:20732415 NCBI chr17:60,542,669...60,631,913
Ensembl chr17:60,543,077...60,631,902 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated acts_upstream_of_or_within ISO (PMID:17681137) RGD PMID:17681137 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24512202)		 UniProt
RGD		 PMID:24512202 GO_REF:0000024 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within		 ISO (PMID:10391943)
MGI:3052343 (PMID:15306813)		 RGD PMID:10391943 PMID:15306813 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (PMID:11959862) RGD PMID:11959862 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO (PMID:16636664) RGD PMID:16636664 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 involved_in ISO (PMID:11034606) RGD PMID:11034606 NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in IMP PMID:21076496 RGD
UniProt		 PMID:12064607 PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Serpinb3 serpin family B member 3 involved_in ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within ISO MGI:108078|MGI:1860298 (PMID:19300477) RGD PMID:19300477 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:1860298|MGI:892014 (PMID:19300477) RGD PMID:19300477 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 acts_upstream_of_or_within ISO MGI:108078|MGI:892014 (PMID:19300477) RGD PMID:19300477 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    negative regulation of biological process 5770
      negative regulation of signaling 1616
        negative regulation of signal transduction 1471
          negative regulation of intracellular signal transduction 768
            negative regulation of MAPK cascade 195
              negative regulation of JNK cascade 37
                negative regulation of JUN kinase activity 14
Path 2
Term Annotations click to browse term
  biological_process 20076
    biological regulation 13559
      regulation of biological process 13136
        regulation of cellular process 12773
          signal transduction 7183
            intracellular signal transduction 3075
              intracellular signaling cassette 2003
                MAPK cascade 864
                  regulation of MAPK cascade 768
                    negative regulation of MAPK cascade 195
                      negative regulation of JNK cascade 37
                        negative regulation of JUN kinase activity 14
paths to the root