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ONTOLOGY REPORT - ANNOTATIONS

Term:thyroid hormone metabolic process
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Accession:GO:0042403 term browser browse the term
Definition:The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
Synonyms:exact_synonym: thyroid hormone metabolism


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thyroid hormone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crym crystallin, mu involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:3703787 (PMID:17264173)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:17264173 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633 		JBrowse link
G Dio1 iodothyronine deiodinase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 involved_in TAS
IBA
ISO
IDA		 GO_REF:0000033
(PMID:19651899)		 GO_Central
RGD		 PMID:19651899 PMID:11934678 PMID:15550511 GO_REF:0000033, RGD:628323, RGD:1626436 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 involved_in TAS
IBA
ISO		 GO_REF:0000033
UniProtKB:P36021 (PMID:26305885)		 GO_Central
RGD		 PMID:26305885 PMID:7622463 GO_REF:0000033, RGD:68236 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Duox2 dual oxidase 2 acts_upstream_of_or_within ISO MGI:3712359 (PMID:17440044) RGD PMID:17440044 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 acts_upstream_of_or_within ISO MGI:3849682 (PMID:19349303) RGD PMID:19349303 NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082 		JBrowse link
G Iyd iodotyrosine deiodinase involved_in ISO
IBA
ISS		 (PMID:25395621)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:25395621 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 acts_upstream_of_or_within ISO MGI:1856525 RGD MGI:85368 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Reln reelin acts_upstream_of_or_within ISO MGI:1856398 RGD MGI:85368 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 acts_upstream_of ISO UniProtKB:P55073 (PMID:26305885) RGD PMID:26305885 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 IDA RGD PMID:11316767 RGD:727314 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 involved_in ISO
IDA		 (PMID:11368519)
PMID:8530477
(MGI:1276823|PMID:9644246)
(PMID:9443824), (PMID:9463486)		 RGD PMID:9443824 PMID:9463486 PMID:9644246 PMID:11368519 PMID:8530477 MGI:1276823, RGD:1299515 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 involved_in ISO (PMID:10199779) RGD PMID:10199779 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tg thyroglobulin acts_upstream_of_or_within ISO MGI:1856829 (PMID:3803305) RGD PMID:3803305 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Ttr transthyretin TAS RGD PMID:11995998 RGD:737655 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
positive regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:35695380 RGD:155630629 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Gata3 GATA binding protein 3 involved_in ISO (PMID:19248180), (PMID:19723756) RGD PMID:19248180 PMID:19723756 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hpn hepsin involved_in ISS
ISO		 GO_REF:0000024
(MGI:3719967|PMID:17620368)		 UniProt
RGD		 PMID:17620368 GO_REF:0000024 MGI:3719967 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Pax8 paired box 8 involved_in ISO
ISS		 (PMID:15356023)
(MGI:3691903|PMID:12586753)
GO_REF:0000024		 RGD
UniProt		 PMID:12586753 PMID:15356023 GO_REF:0000024 MGI:3691903 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 involved_in ISO
IEA		 (PMID:18566113)
GO_REF:0000107		 RGD
Ensembl		 PMID:18566113 GO_REF:0000107 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:1914061 (PMID:22301785) RGD PMID:22301785 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO MGI:2384861 (PMID:22301785) RGD PMID:22301785 NCBI chr 3:109,245,337...109,249,055
Ensembl chr 3:109,245,476...109,248,968 		JBrowse link
thyroid hormone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio2 iodothyronine deiodinase 2 acts_upstream_of_or_within ISO MGI:2182450 (PMID:11731615) RGD PMID:11731615 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:20203194)
MGI:2664293 (PMID:16410833), (PMID:20203194), (PMID:25002520)		 RGD PMID:16410833 PMID:20203194 PMID:25002520 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cga glycoprotein hormones, alpha polypeptide involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1857152 (PMID:12114718)		 GO_Central
RGD		 PMID:12114718 GO_REF:0000033 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Cpq carboxypeptidase Q involved_in IDA
IBA		 PMID:22127294
GO_REF:0000033		 GO_Central PMID:22127294 GO_REF:0000033, RGD:8554022 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546 		JBrowse link
G Ctsb cathepsin B involved_in IEA
ISO		 GO_REF:0000107
(MGI:2664014|PMID:12782676)		 Ensembl
RGD		 PMID:12782676 GO_REF:0000107 MGI:2664014 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsk cathepsin K involved_in ISO
ISS		 (PMID:11082042)
(MGI:2664014|PMID:12782676)
GO_REF:0000024		 RGD
UniProt		 PMID:11082042 PMID:12782676 GO_REF:0000024 MGI:2664014 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L involved_in ISO (MGI:2664014|PMID:12782676) RGD PMID:12782676 MGI:2664014 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Dio2 iodothyronine deiodinase 2 IDA RGD PMID:15550511 RGD:1626436 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Duox1 dual oxidase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 involved_in TAS
IEA		 GO_REF:0000041 UniProt
RGD		 PMID:12538618 GO_REF:0000041, RGD:632568 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Foxe1 forkhead box E1 acts_upstream_of_or_within ISO MGI:2181780 (PMID:9697704) RGD PMID:9697704 NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:1861125 (PMID:10882104) RGD PMID:10882104 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 acts_upstream_of_or_within_negative_effect ISO MGI:1203732 (PMID:24248460) RGD PMID:24248460 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 acts_upstream_of_or_within_negative_effect ISO MGI:1919722|MGI:3710233 (PMID:24248460) RGD PMID:24248460 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771 		JBrowse link
G Slc26a7 solute carrier family 26 member 7 involved_in ISO (MGI:6844647|PMID:30333321) RGD PMID:30333321 MGI:6844647 NCBI chr 5:27,884,400...28,021,865
Ensembl chr 5:27,887,042...28,021,658 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 involved_in TAS
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:8559252 GO_REF:0000002, RGD:68854 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tg thyroglobulin involved_in TAS
IBA
ISO
IEA
IDA		 GO_REF:0000033
(MGI:2664014|PMID:12782676)
GO_REF:0000107
(PMID:11082042), (PMID:12387814)
(PMID:32025030)		 GO_Central
RGD
Ensembl		 PMID:11082042 PMID:12387814 PMID:12782676 PMID:32025030 PMID:11884402 More... GO_REF:0000033 GO_REF:0000107 MGI:2664014, RGD:728752, RGD:1600150 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Tpo thyroid peroxidase involved_in TAS
ISO
IEA		 (PMID:12387814)
GO_REF:0000041		 RGD
UniProt		 PMID:12387814 PMID:15917231 GO_REF:0000041, RGD:1599649 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      hormone metabolic process 251
        thyroid hormone metabolic process 35
          thyroid hormone catabolic process 2
          thyroid hormone generation + 23
Path 2
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      organic substance metabolic process 10971
        organic cyclic compound metabolic process 6031
          phenol-containing compound metabolic process 134
            thyroid hormone metabolic process 35
              thyroid hormone catabolic process 2
              thyroid hormone generation + 23
paths to the root