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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:tumor necrosis factor-mediated signaling pathway
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Accession:GO:0033209 term browser browse the term
Definition:The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: tumor necrosis factor-mediated signalling pathway
 narrow_synonym: TNF-alpha-mediated signaling pathway;   tumor necrosis factor alpha-mediated signaling pathway
 related_synonym: adipocytokine signaling pathway


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tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN4 actinin alpha 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,493,834...47,565,999
Ensembl chr 6:47,493,919...47,565,998 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 involved_in IMP (PMID:23389627) AgBase PMID:23389627 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in IMP (PMID:23389627) AgBase PMID:23389627 NCBI chr 4:94,026,391...94,082,206
Ensembl chr 4:94,026,386...94,080,420 		JBrowse link
G CARD14 caspase recruitment domain family member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,248,337...2,275,015
Ensembl chr12:2,255,038...2,271,588 		JBrowse link
G CD70 CD70 molecule involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:72,528,988...72,531,950
Ensembl chr 2:72,528,400...72,532,951 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G EIF5A eukaryotic translation initiation factor 5A involved_in ISO (PMID:17187778) UniProt PMID:17187778 NCBI chr12:52,659,040...52,664,686 JBrowse link
G FAS Fas cell surface death receptor involved_in IEA GOC GO_REF:0000108 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FOXO3 forkhead box O3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,218...74,760,325 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549 		JBrowse link
G ILK integrin linked kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858 		JBrowse link
G JAK2 Janus kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G KRT18 keratin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10747083) Ensembl
MGI		 PMID:10747083 GO_REF:0000107 NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429 		JBrowse link
G KRT8 keratin 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10747083) Ensembl
MGI		 PMID:10747083 GO_REF:0000107 NCBI chr 5:18,172,423...18,180,277
Ensembl chr 5:18,167,553...18,180,404 		JBrowse link
G LIMS1 LIM zinc finger domain containing 1 involved_in ISO (PMID:21343177) CAFA PMID:21343177 NCBI chr 3:47,607,737...47,704,921
Ensembl chr 3:47,606,230...47,672,884 		JBrowse link
G LOC100627067 tumor necrosis factor receptor superfamily member 26-like involved_in IEA GOC GO_REF:0000108 NCBI chr 2:2,163,609...2,177,107 JBrowse link
G LOC102158193 tumor necrosis factor receptor superfamily member 6-like involved_in IEA GOC GO_REF:0000108 NCBI chr 2:2,186,250...2,198,845 JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in ISO (PMID:25038658) CAFA PMID:25038658 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NOL4L nucleolar protein 4 like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:36,070,836...36,201,035
Ensembl chr17:36,073,655...36,201,145 		JBrowse link
G NOL4L nucleolar protein 4 like involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:36,256,243...36,325,479
Ensembl chr17:36,300,087...36,324,918 		JBrowse link
G NSMAF neutral sphingomyelinase activation associated factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:74,231,488...74,296,681
Ensembl chr 4:74,236,826...74,298,193 		JBrowse link
G PLVAP plasmalemma vesicle associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:60,324,565...60,344,450
Ensembl chr 2:60,324,560...60,344,443 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G RRAGA Ras related GTP binding A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:203,772,063...203,774,580
Ensembl chr 1:203,772,759...203,774,577 		JBrowse link
G ST18 ST18 C2H2C-type zinc finger transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:77,707,143...78,002,016
Ensembl chr 4:77,897,737...78,002,009 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
G TIFA TRAF interacting protein with forkhead associated domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:110,377,817...110,394,190
Ensembl chr 8:110,377,892...110,389,604 		JBrowse link
G TMSB4X thymosin beta 4 X-linked acts_upstream_of_or_within_positive_effect ISO (PMID:21343177) CAFA PMID:21343177 NCBI chr  X:9,649,516...9,651,662
Ensembl chr  X:9,650,179...9,651,661 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:3898078) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:3898078 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a involved_in IEA
IBA		 Ensembl
GO_Central
GOC		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000108 NCBI chr 1:159,128,039...159,187,476
Ensembl chr 1:159,128,038...159,187,481 		JBrowse link
G TNFRSF13C TNF receptor superfamily member 13C involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:6,699,812...6,703,403
Ensembl chr 5:6,699,878...6,703,656 		JBrowse link
G TNFRSF17 TNF receptor superfamily member 17 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:31,137,672...31,141,862
Ensembl chr 3:31,137,682...31,141,735 		JBrowse link
G TNFRSF18 TNF receptor superfamily member 18 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:63,516,037...63,519,323
Ensembl chr 6:63,516,045...63,518,405 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2152007|PMID:11588035) RGD
GOC
Ensembl
InterPro		 PMID:11588035 PMID:20967881 GO_REF:0000002 GO_REF:0000107 MGI:2152007 RGD:5130945 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B involved_in IEA GOC GO_REF:0000108 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147 		JBrowse link
G TNFRSF4 TNF receptor superfamily member 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2683815|PMID:14635034) GOC
GOC		 PMID:14635034 GO_REF:0000108 MGI:2683815 NCBI chr 6:63,523,850...63,526,672
Ensembl chr 6:63,523,804...63,526,666 		JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17442941), (PMID:18269914), (PMID:22437732) Ensembl
MGI		 PMID:17442941 PMID:18269914 PMID:22437732 GO_REF:0000107 NCBI chr11:24,468,011...24,505,421
Ensembl chr11:24,468,110...24,505,477 		JBrowse link
G TNFSF13B TNF superfamily member 13b involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:75,599,296...75,633,044
Ensembl chr11:75,599,598...75,633,041 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in IEA
IBA		 InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:115,447,438...115,460,649
Ensembl chr 9:115,448,973...115,460,950 		JBrowse link
G TP53 tumor protein p53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TRADD TNFRSF1A associated via death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:27,797,594...27,804,654
Ensembl chr 6:27,797,607...27,804,423 		JBrowse link
G TRAF1 TNF receptor associated factor 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:260,948,191...260,973,978
Ensembl chr 1:260,949,111...260,973,709 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in ISO
IEA
IBA		 RGD
TreeGrafter
GO_Central
Ensembl
InterPro		 PMID:10713108 PMID:20967881 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:2298798 RGD:5130945
G TRAF3 TNF receptor associated factor 3 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
G TRAF3IP2 TRAF3 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:77,483,997...77,541,557
Ensembl chr 1:77,487,577...77,541,198 		JBrowse link
G TRAF4 TNF receptor associated factor 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:44,975,639...44,981,650
Ensembl chr12:44,975,632...44,987,104 		JBrowse link
G TRAF5 TNF receptor associated factor 5 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:131,772,810...131,822,555
Ensembl chr 9:131,775,470...131,822,529 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072 		JBrowse link
G TXNDC17 thioredoxin domain containing 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:50,734,669...50,737,309
Ensembl chr12:50,734,619...50,737,078 		JBrowse link
G UMOD uromodulin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28990932) Ensembl
MGI		 PMID:28990932 GO_REF:0000107 NCBI chr 3:25,473,048...25,492,286
Ensembl chr 3:25,473,162...25,492,278 		JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G APOA1 apolipoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chr17:62,351,663...62,356,220 JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr13:78,794,573...78,823,761
Ensembl chr13:78,794,580...78,822,796 		JBrowse link
G DICER1 dicer 1, ribonuclease III involved_in
acts_upstream_of		 IEA
ISO		 (PMID:26435691) Ensembl
ARUK-UCL		 PMID:26435691 GO_REF:0000107 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,848,797...78,880,733
Ensembl chr11:78,848,797...78,881,284 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,664,869...52,667,643
Ensembl chr12:52,664,875...52,667,610 		JBrowse link
G H2BC11 H2B clustered histone 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:21,219,729...21,220,563
Ensembl chr 7:21,220,123...21,220,503 		JBrowse link
G LOC100510975 coiled-coil domain-containing protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:59,052,979...59,144,791
Ensembl chr10:59,052,915...59,144,797 		JBrowse link
G MIR125B-1 microRNA mir-125b-1 acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 9:49,109,435...49,109,514
Ensembl chr 9:49,109,435...49,109,514 		JBrowse link
G MIR130A microRNA mir-130a acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 2:13,296,695...13,296,773
Ensembl chr 2:13,296,695...13,296,773 		JBrowse link
G MIR152 microRNA mir-152 involved_in ISO (PMID:24813629) BHF-UCL PMID:24813629 NCBI chr12:24,292,249...24,292,328
Ensembl chr12:24,292,251...24,292,336 		JBrowse link
G MIR27B microRNA mir-27b acts_upstream_of_or_within ISO (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr10:27,079,963...27,080,042
Ensembl chr10:27,079,954...27,080,056 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chr16:47,700,869...47,710,036 JBrowse link
G NLRP2B NLR family pyrin domain containing 2B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:59,186,265...59,186,402 JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24113711)
(PMID:23950925)		 MGI
Ensembl		 PMID:23950925 PMID:24113711 GO_REF:0000107 NCBI chr 2:5,950,552...5,959,786
Ensembl chr 2:5,948,849...5,959,734 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr 2:74,702,915...74,729,792
Ensembl chr 2:74,702,945...74,729,775 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta acts_upstream_of
involved_in		 ISO
IEA		 (PMID:28159925) ARUK-UCL
Ensembl		 PMID:28159925 GO_REF:0000107 NCBI chr15:54,295,786...54,325,220
Ensembl chr15:54,296,113...54,325,213 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:40,075,259...40,151,034
Ensembl chr12:40,075,337...40,151,043 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:67,970,972...68,048,681
Ensembl chr15:67,952,173...68,048,963 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125 		JBrowse link
G TRAIP TRAF interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:32,332,336...32,380,988
Ensembl chr13:32,345,599...32,379,766 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:101,399,374...101,440,021
Ensembl chr  X:101,399,812...101,440,013 		JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995 		JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase involved_in ISO (PMID:16920334) UniProt PMID:16920334 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328 		JBrowse link
G CPNE1 copine 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:38,956,489...38,997,189
Ensembl chr17:38,956,673...38,964,890 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818) ARUK-UCL PMID:22733818 MGI:6391873 NCBI chr 6:87,363,911...87,390,371
Ensembl chr 6:87,363,912...87,390,288 		JBrowse link
G LOC100522887 caspase-13 involved_in ISO (PMID:16920334) UniProt PMID:16920334 NCBI chr 9:35,167,567...35,185,791 JBrowse link
G MMP8 matrix metallopeptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:33,384,034...33,397,637
Ensembl chr 9:33,384,033...33,396,947 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in IEA Ensembl GO_REF:0000107
G TRIM32 tripartite motif containing 32 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr 1:257,051,421...257,066,911
Ensembl chr 1:257,054,228...257,066,909 		JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:30,887,784...30,961,685
Ensembl chr 8:30,887,830...30,963,762 		JBrowse link
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,081...34,121,264 		JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 4:20,645,002...20,935,769
Ensembl chr 4:20,645,610...20,935,540 		JBrowse link
G HIPK1 homeodomain interacting protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:106,570,950...106,627,114
Ensembl chr 4:106,572,755...106,627,418 		JBrowse link
G NKIRAS1 NFKB inhibitor interacting Ras like 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr13:10,686,480...10,716,162
Ensembl chr13:10,686,488...10,716,099 		JBrowse link
G NKIRAS2 NFKB inhibitor interacting Ras like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr12:20,717,545...20,723,141
Ensembl chr12:20,717,547...20,723,704 		JBrowse link
G OTULIN OTU deubiquitinase with linear linkage specificity involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr16:4,063,037...4,097,112
Ensembl chr16:4,063,071...4,093,198 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17442941) Ensembl
MGI		 PMID:17442941 GO_REF:0000107 NCBI chr 4:99,463,418...99,475,141
Ensembl chr 4:99,465,690...99,475,140 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G SHARPIN SHANK associated RH domain interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:600,698...605,711
Ensembl chr 4:600,698...605,701 		JBrowse link
G SPATA2 spermatogenesis associated 2 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:51,489,696...51,500,900
Ensembl chr17:51,489,701...51,500,669 		JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,114,946...5,122,580
Ensembl chr12:5,114,947...5,120,083 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    cellular process 16826
      signal transduction 6963
        cell surface receptor signaling pathway 2809
          cytokine-mediated signaling pathway 498
            tumor necrosis factor-mediated signaling pathway 99
              negative regulation of tumor necrosis factor-mediated signaling pathway 27
              positive regulation of tumor necrosis factor-mediated signaling pathway 11
              regulation of tumor necrosis factor-mediated signaling pathway + 51
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to chemical 5803
        response to peptide 1209
          response to cytokine 1185
            cellular response to cytokine stimulus 1055
              cytokine-mediated signaling pathway 498
                tumor necrosis factor-mediated signaling pathway 99
                  negative regulation of tumor necrosis factor-mediated signaling pathway 27
                  positive regulation of tumor necrosis factor-mediated signaling pathway 11
                  regulation of tumor necrosis factor-mediated signaling pathway + 51
paths to the root