UMOD (uromodulin) - Rat Genome Database

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Gene: UMOD (uromodulin) Sus scrofa
Analyze
Symbol: UMOD
Name: uromodulin
RGD ID: 14205436
Description: ENCODES a protein that exhibits calcium ion binding (inferred); IgG binding (inferred); INVOLVED IN apoptotic process (ortholog); apoptotic signaling pathway (ortholog); autophagy (ortholog); ASSOCIATED WITH Autosomal Dominant Tubulointerstitial Kidney Disease 1 (ortholog); chronic kidney disease (ortholog); essential hypertension (ortholog); FOUND IN apical part of cell (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,473,162 - 25,492,278 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1325,473,048 - 25,492,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,195,083 - 26,205,810 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA)
apoptotic process  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
autophagy  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
cellular response to unfolded protein  (IEA,ISO)
chaperone-mediated protein folding  (IEA,ISO)
chemical homeostasis  (IEA,ISO)
chloride ion homeostasis  (IEA,ISO)
citric acid secretion  (IEA,ISO)
collecting duct development  (IEA,ISO)
connective tissue replacement  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
endoplasmic reticulum organization  (IEA,ISO)
ERAD pathway  (IEA,ISO)
gene expression  (IEA,ISO)
glomerular filtration  (IEA,ISO)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA)
immune system process  (IEA)
inflammatory response  (IEA,ISO)
innate immune response  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular chloride ion homeostasis  (IEA,ISO)
intracellular phosphate ion homeostasis  (IEA,ISO)
intracellular sodium ion homeostasis  (IEA,ISO)
juxtaglomerular apparatus development  (IEA,ISO)
kidney development  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA)
lipid metabolic process  (IEA,ISO)
loop of Henle development  (IEA,ISO)
metanephric ascending thin limb development  (IEA)
metanephric distal convoluted tubule development  (IEA)
metanephric thick ascending limb development  (IEA)
micturition  (IEA,ISO)
monoatomic ion homeostasis  (IEA)
multicellular organismal response to stress  (IEA,ISO)
multicellular organismal-level homeostasis  (IEA,ISO)
multicellular organismal-level water homeostasis  (IEA,ISO)
neutrophil migration  (IBA,IEA)
organ or tissue specific immune response  (IEA,ISO)
phosphate ion homeostasis  (IEA,ISO)
potassium ion homeostasis  (IEA,ISO)
protein localization to vacuole  (IEA,ISO)
protein transport into plasma membrane raft  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of protein transport  (IEA,ISO)
regulation of urine volume  (IEA,ISO)
renal sodium ion absorption  (IEA,ISO)
renal urate salt excretion  (IEA,ISO)
renal water homeostasis  (IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to organic substance  (ISO)
response to unfolded protein  (IEA,ISO)
response to water deprivation  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
RNA splicing  (IEA,ISO)
sodium ion homeostasis  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
urate transport  (IEA,ISO)
urea transmembrane transport  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UMOD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,473,162 - 25,492,278 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1325,473,048 - 25,492,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,195,083 - 26,205,810 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UMOD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381620,333,051 - 20,356,301 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1620,333,051 - 20,356,301 (-)EnsemblGRCh38hg38GRCh38
GRCh371620,344,373 - 20,364,037 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361620,251,874 - 20,271,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 341620,251,874 - 20,271,538NCBI
Celera1619,493,555 - 19,513,244 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,881,007 - 18,900,856 (-)NCBIHuRef
CHM1_11620,432,269 - 20,452,397 (-)NCBICHM1_1
T2T-CHM13v2.01620,264,004 - 20,287,315 (-)NCBIT2T-CHM13v2.0
Umod
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,061,931 - 119,078,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,061,934 - 119,078,505 (-)EnsemblGRCm39 Ensembl
GRCm387119,462,708 - 119,479,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7119,462,711 - 119,479,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv377126,606,380 - 126,622,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,254,013 - 119,270,404 (-)NCBIMGSCv36mm8
Celera7119,386,384 - 119,402,859 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map763.88NCBI
Umod
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,247,676 - 183,261,665 (-)NCBIGRCr8
mRatBN7.21173,816,341 - 173,829,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,816,339 - 173,830,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,127,287 - 182,141,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,313,389 - 189,327,107 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,048,615 - 182,062,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,186,027 - 189,199,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,186,026 - 189,199,376 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,127,939 - 196,141,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,729,212 - 177,742,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11177,868,457 - 177,881,798 (-)NCBI
Celera1171,569,071 - 171,582,409 (-)NCBICelera
Cytogenetic Map1q35NCBI
Umod
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554423,985,308 - 3,999,598 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554423,986,936 - 4,001,155 (-)NCBIChiLan1.0ChiLan1.0
UMOD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,594,038 - 21,613,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,115,698 - 26,135,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,960,456 - 17,980,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11620,429,822 - 20,449,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1620,430,085 - 20,449,121 (-)Ensemblpanpan1.1panPan2
UMOD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,991,459 - 25,006,735 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,991,459 - 25,006,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha626,355,935 - 26,369,584 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0625,145,508 - 25,160,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl625,145,508 - 25,160,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,946,350 - 24,961,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,841,732 - 24,857,098 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0625,229,622 - 25,244,770 (+)NCBIUU_Cfam_GSD_1.0
Umod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344117,735,331 - 117,748,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365015,833,391 - 5,846,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365015,833,391 - 5,846,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UMOD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1518,620,927 - 18,641,312 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl518,619,895 - 18,638,719 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606811,265,375 - 11,285,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Umod
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,640,214 - 3,652,324 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,639,955 - 3,654,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UMOD
618 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system renal system reproductive system respiratory system
High
Medium 2
Low 1 1
Below cutoff 2 3 3 1

Sequence


RefSeq Acc Id: ENSSSCT00000008610   ⟹   ENSSSCP00000008389
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl325,473,162 - 25,492,278 (+)Ensembl
RefSeq Acc Id: XM_021086524   ⟹   XP_020942183
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1325,473,048 - 25,492,286 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020942183   ⟸   XM_021086524
- UniProtKB: F1RPA9 (UniProtKB/TrEMBL),   A0A8D0M8S3 (UniProtKB/TrEMBL),   A0A8D0TC81 (UniProtKB/TrEMBL),   A0A8D1TI07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000008389   ⟸   ENSSSCT00000008610
Protein Domains
EGF-like   ZP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005045934 UniProtKB/TrEMBL
  ENSSSCG00025073258 UniProtKB/TrEMBL
  ENSSSCG00030018535 UniProtKB/TrEMBL
  ENSSSCG00035017169 UniProtKB/TrEMBL
  ENSSSCG00040024252 UniProtKB/TrEMBL
  ENSSSCG00045017522 UniProtKB/TrEMBL
  ENSSSCG00050049419 UniProtKB/TrEMBL
  ENSSSCG00055013020 UniProtKB/TrEMBL
  ENSSSCG00065073554 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008610 ENTREZGENE
  ENSSSCT00000008610.5 UniProtKB/TrEMBL
  ENSSSCT00005074344.1 UniProtKB/TrEMBL
  ENSSSCT00025100824.1 UniProtKB/TrEMBL
  ENSSSCT00030025590.1 UniProtKB/TrEMBL
  ENSSSCT00035022024.1 UniProtKB/TrEMBL
  ENSSSCT00040032452.1 UniProtKB/TrEMBL
  ENSSSCT00045029851.1 UniProtKB/TrEMBL
  ENSSSCT00050067236.1 UniProtKB/TrEMBL
  ENSSSCT00055025605.1 UniProtKB/TrEMBL
  ENSSSCT00065101255.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  ZP-C UniProtKB/TrEMBL
  ZP_chr UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/TrEMBL
NCBI Gene UMOD ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/TrEMBL
  UROMODULIN UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/TrEMBL
PRINTS ZPELLUCIDA UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  ZP_1 UniProtKB/TrEMBL
  ZP_2 UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SM00241 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8D0M8S3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TC81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0VWA8_PIG UniProtKB/TrEMBL
  A0A8D0YZ04_PIG UniProtKB/TrEMBL
  A0A8D1K6M9_PIG UniProtKB/TrEMBL
  A0A8D1QDZ7_PIG UniProtKB/TrEMBL
  A0A8D1TI07 ENTREZGENE, UniProtKB/TrEMBL
  F1RPA9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94698 ENTREZGENE