MIR125B-1 (microRNA mir-125b-1) - Rat Genome Database

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Gene: MIR125B-1 (microRNA mir-125b-1) Sus scrofa
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Symbol: MIR125B-1 (Ensembl: ssc-mir-125b-1)
Name: microRNA mir-125b-1 (Ensembl:ssc-mir-125b-1)
RGD ID: 14070173
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 125b-1; ssc-mir-125b-1
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,109,435 - 49,109,514 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,109,435 - 49,109,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,334,908 - 54,334,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (ISO)
cellular response to forskolin  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin D  (ISO)
common myeloid progenitor cell proliferation  (ISO)
hematopoietic stem cell differentiation  (ISO)
juxtaglomerular apparatus development  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
ossification  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:19917043   PMID:21312241   PMID:24499489  


Genomics

Comparative Map Data
MIR125B-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,109,435 - 49,109,514 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,109,435 - 49,109,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,334,908 - 54,334,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIR125B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,099,757 - 122,099,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,099,757 - 122,099,844 (-)EnsemblGRCh38hg38GRCh38
GRCh3711121,970,465 - 121,970,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611121,475,674 - 121,475,761 (-)NCBINCBI36Build 36hg18NCBI36
Celera11119,131,144 - 119,131,231 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,917,003 - 117,917,090 (-)NCBIHuRef
CHM1_111121,857,766 - 121,857,853 (-)NCBICHM1_1
T2T-CHM13v2.011122,128,759 - 122,128,846 (-)NCBIT2T-CHM13v2.0
Mir125b-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,493,222 - 41,493,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,493,222 - 41,493,298 (+)EnsemblGRCm39 Ensembl
GRCm38941,581,926 - 41,582,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,581,926 - 41,582,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv37941,390,009 - 41,390,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera938,821,699 - 38,821,775 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.41NCBI
Mir125b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,850,036 - 50,850,122 (+)NCBIGRCr8
mRatBN7.2841,952,966 - 41,953,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,952,966 - 41,953,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx847,445,457 - 47,445,543 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,724,100 - 45,724,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,591,670 - 43,591,756 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0845,798,260 - 45,798,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,798,260 - 45,798,346 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0844,272,846 - 44,272,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera841,551,438 - 41,551,524 (+)NCBICelera
Cytogenetic Map8q22NCBI
MIR125B-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1512,097,672 - 12,097,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl512,097,658 - 12,097,745 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha512,152,730 - 12,152,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0512,047,627 - 12,047,687 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl512,047,613 - 12,047,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1512,151,360 - 12,151,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0512,090,768 - 12,090,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0512,129,464 - 12,129,524 (+)NCBIUU_Cfam_GSD_1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 2 11 1
Low 2 2 3 3 1 11 1 1
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000026883
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl949,109,435 - 49,109,514 (-)Ensembl
RefSeq Acc Id: NR_038579
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1949,109,435 - 49,109,514 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025183 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000026883 ENTREZGENE
miRBase MI0013172 ENTREZGENE
NCBI Gene MIR125B-1 ENTREZGENE
RNAcentral URS0000209905 RNACentral
  URS000075D53E RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR125B-1  microRNA mir-125b-1    microRNA 125b-1  Symbol and/or name change 5135510 APPROVED