TRAF3IP2 (TRAF3 interacting protein 2) - Rat Genome Database

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Gene: TRAF3IP2 (TRAF3 interacting protein 2) Sus scrofa
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Symbol: TRAF3IP2
Name: TRAF3 interacting protein 2
RGD ID: 14241979
Description: ENCODES a protein that exhibits signaling receptor binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN B cell apoptotic process (ortholog); B cell mediated immunity (ortholog); cellular response to cytokine stimulus (ortholog); ASSOCIATED WITH Candidiasis, Familial, 8 (ortholog); Discoid Lupus Erythematosus (ortholog); psoriasis (ortholog); FOUND IN cytoplasmic vesicle (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: adapter protein CIKS
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,480,926 - 77,541,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1177,483,997 - 77,541,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,044,462 - 87,102,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell affinity maturation  (IEA)
B cell apoptotic process  (IEA,ISO)
B cell homeostasis  (IEA)
B cell mediated immunity  (ISO)
CD40 signaling pathway  (IEA)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-17  (ISO)
cytokine-mediated signaling pathway  (ISO)
eosinophil homeostasis  (IEA)
eosinophil mediated immunity  (IEA)
establishment of T cell polarity  (IEA)
gene expression  (ISO)
heart development  (IEA)
humoral immune response  (IBA,ISO)
immune response  (ISO)
inflammatory response  (ISO)
interleukin-17-mediated signaling pathway  (IEA)
interleukin-17A-mediated signaling pathway  (IEA)
kidney development  (IEA)
leukocyte activation involved in inflammatory response  (IEA)
lymph node development  (IEA)
mRNA stabilization  (IEA)
mucus secretion  (IEA)
neutrophil activation  (IEA)
positive regulation of defense response to virus by host  (IEA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA)
protein import into nucleus  (IEA)
protein K63-linked ubiquitination  (IEA)
protein localization to nucleus  (ISO)
protein localization to P-body  (IEA)
protein polyubiquitination  (ISO)
protein ubiquitination  (ISO)
response to cytokine  (ISO)
response to xenobiotic stimulus  (IEA)
signal transduction involved in regulation of gene expression  (IEA)
skin development  (IEA)
spleen development  (IEA)
T cell activation  (ISO)
T cell differentiation  (IEA)
T-helper 17 type immune response  (IEA)
transitional two stage B cell differentiation  (IEA)
tumor necrosis factor-mediated signaling pathway  (IEA)
type 2 immune response  (IEA)

Cellular Component
cytoplasmic vesicle  (IEA,ISO)
nucleus  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
TRAF3IP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,480,926 - 77,541,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1177,483,997 - 77,541,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,044,462 - 87,102,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF3IP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6111,555,381 - 111,606,906 (-)EnsemblGRCh38hg38GRCh38
GRCh386111,555,381 - 111,605,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376111,876,584 - 111,927,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,986,836 - 112,034,014 (-)NCBINCBI36hg18NCBI36
Build 346111,986,835 - 112,034,014NCBI
Celera6112,626,739 - 112,674,049 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6109,448,986 - 109,500,061 (-)NCBIHuRef
CHM1_16112,139,458 - 112,190,300 (-)NCBICHM1_1
Traf3ip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,488,930 - 39,531,303 (+)NCBIGRCm39mm39
GRCm39 Ensembl1039,488,930 - 39,531,303 (+)Ensembl
GRCm381039,612,934 - 39,655,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,612,934 - 39,655,307 (+)EnsemblGRCm38mm10GRCm38
MGSCv371039,332,740 - 39,375,113 (+)NCBIGRCm37mm9NCBIm37
MGSCv361039,302,350 - 39,344,723 (+)NCBImm8
Celera1040,498,927 - 40,541,335 (+)NCBICelera
Cytogenetic Map10B1NCBI
Traf3ip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22043,011,405 - 43,054,654 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2043,011,450 - 43,054,667 (+)Ensembl
Rnor_6.02044,679,861 - 44,722,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,680,449 - 44,722,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,401,898 - 46,445,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,747,622 - 43,792,255 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2043,727,541 - 43,769,944 (+)NCBICelera
Cytogenetic Map20q12NCBI
Traf3ip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541136,326,926 - 36,363,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541136,328,152 - 36,363,614 (-)NCBIChiLan1.0ChiLan1.0
TRAF3IP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16113,443,540 - 113,490,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,444,005 - 113,485,533 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06109,367,333 - 109,414,601 (-)NCBIMhudiblu_PPA_v0panPan3
TRAF3IP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,029,861 - 68,070,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,030,197 - 68,058,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,849,673 - 67,891,354 (-)NCBI
ROS_Cfam_1.01268,911,754 - 68,953,406 (-)NCBI
UMICH_Zoey_3.11268,263,251 - 68,304,918 (-)NCBI
UNSW_CanFamBas_1.01268,109,790 - 68,151,470 (-)NCBI
UU_Cfam_GSD_1.01268,435,643 - 68,477,316 (-)NCBI
Traf3ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,076,436 - 103,116,386 (-)NCBI
SpeTri2.0NW_004936679308,508 - 348,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF3IP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11362,272,893 - 62,320,096 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1362,285,589 - 62,324,312 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604034,579,431 - 34,626,946 (+)NCBIVero_WHO_p1.0
Traf3ip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624933507,879 - 558,357 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 6 2 4 2 3
Low 4 2 3 1 2 23 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004883   ⟹   ENSSSCP00000004768
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl177,487,577 - 77,536,144 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046753   ⟹   ENSSSCP00000032422
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl177,487,579 - 77,541,187 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053110   ⟹   ENSSSCP00000036070
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl177,483,997 - 77,541,210 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000076757   ⟹   ENSSSCP00000070276
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl177,480,926 - 77,541,210 (-)Ensembl
RefSeq Acc Id: XM_001924787   ⟹   XP_001924822
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1177,487,315 - 77,541,557 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003353287   ⟹   XP_003353335
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1177,487,315 - 77,541,523 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992757   ⟹   XP_013848211
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1177,483,997 - 77,541,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021091285   ⟹   XP_020946944
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1177,487,315 - 77,541,523 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021091306   ⟹   XP_020946965
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1177,487,315 - 77,505,115 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013848211   ⟸   XM_013992757
- Peptide Label: isoform X2
- UniProtKB: A0A286ZX79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001924822   ⟸   XM_001924787
- Peptide Label: isoform X1
- UniProtKB: F1RZP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946944   ⟸   XM_021091285
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003353335   ⟸   XM_003353287
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020946965   ⟸   XM_021091306
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000070276   ⟸   ENSSSCT00000076757
RefSeq Acc Id: ENSSSCP00000032422   ⟸   ENSSSCT00000046753
RefSeq Acc Id: ENSSSCP00000036070   ⟸   ENSSSCT00000053110
RefSeq Acc Id: ENSSSCP00000004768   ⟸   ENSSSCT00000004883
Protein Domains
SEFIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022706 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004768 UniProtKB/TrEMBL
  ENSSSCP00000032422 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000036070 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000070276 UniProtKB/TrEMBL
  ENSSSCP00070038047 UniProtKB/TrEMBL
  ENSSSCP00070038051 UniProtKB/TrEMBL
  ENSSSCP00070038056 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004883 UniProtKB/TrEMBL
  ENSSSCT00000046753 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053110 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000076757 UniProtKB/TrEMBL
  ENSSSCT00070045151 UniProtKB/TrEMBL
  ENSSSCT00070045154 UniProtKB/TrEMBL
  ENSSSCT00070045159 UniProtKB/TrEMBL
InterPro SEFIR_dom UniProtKB/TrEMBL
KEGG Report ssc:100157000 UniProtKB/TrEMBL
NCBI Gene TRAF3IP2 ENTREZGENE
Pfam SEFIR UniProtKB/TrEMBL
PROSITE SEFIR UniProtKB/TrEMBL
UniProt A0A286ZLT6_PIG UniProtKB/TrEMBL
  A0A286ZX79 ENTREZGENE, UniProtKB/TrEMBL
  A0A480SCL2_PIG UniProtKB/TrEMBL
  A0A4X1V5J2_PIG UniProtKB/TrEMBL
  A0A4X1V8T1_PIG UniProtKB/TrEMBL
  A0A4X1V9X5_PIG UniProtKB/TrEMBL
  A0A5G2QZG0_PIG UniProtKB/TrEMBL
  F1RZP1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94361 ENTREZGENE