CHUK (component of inhibitor of nuclear factor kappa B kinase complex) - Rat Genome Database

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Gene: CHUK (component of inhibitor of nuclear factor kappa B kinase complex) Sus scrofa
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Symbol: CHUK
Name: component of inhibitor of nuclear factor kappa B kinase complex
RGD ID: 14160578
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN defense response to virus (ortholog); integrin-mediated signaling pathway (ortholog); lactation (ortholog); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH asthma (ortholog); autistic disorder (ortholog); bacterial pneumonia (ortholog); FOUND IN CD40 receptor complex (ortholog); cytoplasmic side of plasma membrane (ortholog); IkappaB kinase complex (ortholog); INTERACTS WITH deoxynivalenol; fumonisin B1; melatonin
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conserved helix-loop-helix ubiquitous kinase; IkB kinase-a; IKK-alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,186,319 - 100,229,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,188,300 - 100,229,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,948,057 - 101,989,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,811 - 102,274,037 (-)NCBICHM1_1
T2T-CHM13v2.010101,070,354 - 101,113,853 (-)NCBIT2T-CHM13v2.0
Chuk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)EnsemblGRCm39 Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBIMGSCv36mm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
Chuk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,908,748 - 252,944,273 (-)NCBIGRCr8
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
Chuk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,067,203 - 6,102,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,066,026 - 6,102,066 (-)NCBIChiLan1.0ChiLan1.0
CHUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,077,682 - 112,118,610 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,083,001 - 112,123,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,794,228 - 96,835,449 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,276,290 - 100,317,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,280,490 - 100,316,918 (-)Ensemblpanpan1.1panPan2
CHUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,964,670 - 13,001,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,965,479 - 13,001,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,147,837 - 13,184,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,433,260 - 13,470,158 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,433,260 - 13,470,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,980,085 - 13,016,958 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,017,918 - 13,055,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,152,231 - 13,189,348 (-)NCBIUU_Cfam_GSD_1.0
Chuk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,995,060 - 34,039,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493663633,673 - 79,194 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493663633,933 - 78,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chuk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,022,419 - 12,052,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473712,022,081 - 12,052,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CHUK
524 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000011540   ⟹   ENSSSCP00000011239
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)Ensembl
RefSeq Acc Id: NM_001114279   ⟹   NP_001107751
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001107751   ⟸   NM_001114279
- UniProtKB: B0LXP6 (UniProtKB/TrEMBL),   A0A4X1U511 (UniProtKB/TrEMBL),   A0A4X1U526 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000011239   ⟸   ENSSSCT00000011540
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015069435 UniProtKB/TrEMBL
  ENSSSCG00025057450 UniProtKB/TrEMBL
  ENSSSCG00030067777 UniProtKB/TrEMBL
  ENSSSCG00035034495 UniProtKB/TrEMBL
  ENSSSCG00040025017 UniProtKB/TrEMBL
  ENSSSCG00045014188 UniProtKB/TrEMBL
  ENSSSCG00050076885 UniProtKB/TrEMBL
  ENSSSCG00055002732 UniProtKB/TrEMBL
  ENSSSCG00060063457 UniProtKB/TrEMBL
  ENSSSCG00065054648 UniProtKB/TrEMBL
  ENSSSCG00070014081 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011540 ENTREZGENE
  ENSSSCT00000011540.5 UniProtKB/TrEMBL
  ENSSSCT00015092979.1 UniProtKB/TrEMBL
  ENSSSCT00015093093.1 UniProtKB/TrEMBL
  ENSSSCT00025078638.1 UniProtKB/TrEMBL
  ENSSSCT00025079312.1 UniProtKB/TrEMBL
  ENSSSCT00030094785.1 UniProtKB/TrEMBL
  ENSSSCT00030094813.1 UniProtKB/TrEMBL
  ENSSSCT00035045703.1 UniProtKB/TrEMBL
  ENSSSCT00035045735.1 UniProtKB/TrEMBL
  ENSSSCT00040033432.1 UniProtKB/TrEMBL
  ENSSSCT00040033538.1 UniProtKB/TrEMBL
  ENSSSCT00045024187.1 UniProtKB/TrEMBL
  ENSSSCT00045024352.1 UniProtKB/TrEMBL
  ENSSSCT00050105711.1 UniProtKB/TrEMBL
  ENSSSCT00050105746.1 UniProtKB/TrEMBL
  ENSSSCT00055005224.1 UniProtKB/TrEMBL
  ENSSSCT00055005287.1 UniProtKB/TrEMBL
  ENSSSCT00060086561.1 UniProtKB/TrEMBL
  ENSSSCT00060086705.1 UniProtKB/TrEMBL
  ENSSSCT00065074850.1 UniProtKB/TrEMBL
  ENSSSCT00065074907.1 UniProtKB/TrEMBL
  ENSSSCT00070027560.1 UniProtKB/TrEMBL
  ENSSSCT00070027575.1 UniProtKB/TrEMBL
  ENSSSCT00070027585.1 UniProtKB/TrEMBL
  ENSSSCT00070027608.1 UniProtKB/TrEMBL
  ENSSSCT00070027620.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/TrEMBL
  IKK UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100135662 UniProtKB/TrEMBL
NCBI Gene CHUK ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART IKKbetaNEMObind UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1U2G9_PIG UniProtKB/TrEMBL
  A0A4X1U4M9_PIG UniProtKB/TrEMBL
  A0A4X1U511 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U526 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U537_PIG UniProtKB/TrEMBL
  B0LXP6 ENTREZGENE, UniProtKB/TrEMBL
  F1S8V5_PIG UniProtKB/TrEMBL
UniProt Secondary F1S8V4 UniProtKB/TrEMBL
VGNC ID VGNC:86688 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 CHUK  component of inhibitor of nuclear factor kappa B kinase complex    conserved helix-loop-helix ubiquitous kinase  Symbol and/or name change 5135510 APPROVED