EXT1 (exostosin glycosyltransferase 1) - Rat Genome Database

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Gene: EXT1 (exostosin glycosyltransferase 1) Sus scrofa
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Symbol: EXT1
Name: exostosin glycosyltransferase 1
RGD ID: 14058091
Description: ENCODES a protein that exhibits glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (inferred); metal ion binding (inferred); N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity (inferred); INVOLVED IN antigen processing and presentation (ortholog); axon guidance (ortholog); basement membrane organization (ortholog); ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); chondrosarcoma (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ER-resident type II transmembrane glycosyltransferase; exostosin-1; putative tumour suppressor/hereditary multiple exostoses candidate
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl420,645,809 - 20,935,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1420,645,002 - 20,935,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2421,837,627 - 22,128,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (IEA,ISO)
axon guidance  (IEA,ISO)
basement membrane organization  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
bone growth  (ISO)
bone morphogenesis  (ISO)
bone resorption  (IEA,ISO)
brain development  (ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cartilage development involved in endochondral bone morphogenesis  (IEA,ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular component organization  (ISO)
cellular polysaccharide biosynthetic process  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to virus  (IEA,ISO)
chondrocyte differentiation  (ISO)
chondrocyte hypertrophy  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
chondroitin sulfate metabolic process  (IEA,ISO)
collagen fibril organization  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
dendrite self-avoidance  (IEA,ISO)
dendritic cell migration  (IEA,ISO)
developmental growth involved in morphogenesis  (IEA,ISO)
embryonic morphogenesis  (ISO)
embryonic skeletal joint development  (IEA,ISO)
endochondral bone growth  (IEA,ISO)
endochondral bone morphogenesis  (ISO)
endochondral ossification  (IEA,ISO)
endoderm development  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
epithelium development  (ISO)
fear response  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
fluid transport  (IEA,ISO)
gastrulation  (IEA,ISO)
gene expression  (IEA,ISO)
glandular epithelial cell differentiation  (IEA,ISO)
glomerular basement membrane development  (IEA,ISO)
glomerular visceral epithelial cell differentiation  (IEA,ISO)
glycosaminoglycan biosynthetic process  (ISO)
hair cycle process  (ISO)
hair follicle morphogenesis  (IEA,ISO)
heart contraction  (IEA,ISO)
heart field specification  (IEA,ISO)
hematopoietic progenitor cell differentiation  (ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hematopoietic stem cell homeostasis  (IEA,ISO)
hematopoietic stem cell migration to bone marrow  (IEA,ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process  (IEA)
heparin biosynthetic process  (IEA,ISO)
heparin metabolic process  (ISO)
hypersensitivity  (IEA,ISO)
leukocyte tethering or rolling  (IEA,ISO)
limb joint morphogenesis  (IEA,ISO)
lymphocyte adhesion to endothelial cell of high endothelial venule  (IEA,ISO)
lymphocyte migration into lymphoid organs  (IEA,ISO)
mesenchymal cell differentiation involved in bone development  (IEA,ISO)
mesenchyme development  (ISO)
mesoderm development  (IEA,ISO)
motor behavior  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
multicellular organismal water homeostasis  (IEA,ISO)
neural crest cell differentiation  (IEA,ISO)
neuron projection development  (ISO)
olfactory bulb development  (IEA,ISO)
optic nerve development  (IEA,ISO)
ossification  (ISO)
ossification involved in bone maturation  (IEA,ISO)
perichondral bone morphogenesis  (IEA,ISO)
protein catabolic process  (IEA,ISO)
protein glycosylation  (IEA)
protein-containing complex assembly  (IEA,ISO)
proteoglycan biosynthetic process  (ISO)
regulation of blood pressure  (IEA,ISO)
response to growth factor  (ISO)
response to heparin  (IEA,ISO)
response to leukemia inhibitory factor  (IEA,ISO)
response to light intensity  (IEA,ISO)
response to virus  (ISO)
sebaceous gland development  (IEA,ISO)
smoothened signaling pathway  (ISO)
smoothened signaling pathway involved in lung development  (IEA,ISO)
social behavior  (IEA,ISO)
sodium ion homeostasis  (IEA,ISO)
stem cell division  (IEA,ISO)
stomach development  (IEA,ISO)
sulfation  (IEA,ISO)
sweat gland development  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
tight junction organization  (IEA,ISO)
TNFSF11-mediated signaling pathway  (IEA,ISO)
vacuole organization  (IEA,ISO)
vasodilation  (IEA,ISO)
vocalization behavior  (IEA,ISO)
wound healing  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
EXT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl420,645,809 - 20,935,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1420,645,002 - 20,935,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2421,837,627 - 22,128,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8117,794,490 - 118,111,826 (-)EnsemblGRCh38hg38GRCh38
GRCh388117,794,490 - 118,111,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378118,806,729 - 119,124,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,880,783 - 119,193,239 (-)NCBINCBI36hg18NCBI36
Build 348118,880,786 - 119,193,239NCBI
Celera8115,000,160 - 115,312,582 (-)NCBI
Cytogenetic Map8q24.11NCBI
HuRef8114,138,448 - 114,450,830 (-)NCBIHuRef
CHM1_18118,852,044 - 119,165,143 (-)NCBICHM1_1
Ext1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391552,931,657 - 53,209,579 (-)NCBIGRCm39mm39
GRCm39 Ensembl1552,927,434 - 53,209,555 (-)Ensembl
GRCm381553,068,261 - 53,346,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1553,064,038 - 53,346,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371552,899,816 - 53,177,738 (-)NCBIGRCm37mm9NCBIm37
MGSCv361552,898,622 - 53,176,027 (-)NCBImm8
Celera1554,621,498 - 54,903,011 (-)NCBICelera
Cytogenetic Map15CNCBI
cM Map1520.0NCBI
Ext1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2784,375,769 - 84,654,625 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl784,375,784 - 84,655,357 (-)Ensembl
Rnor_6.0792,605,008 - 92,881,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl792,605,728 - 92,882,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0793,245,551 - 93,521,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4789,392,837 - 89,671,523 (-)NCBIRGSC3.4rn4RGSC3.4
Celera781,215,848 - 81,493,311 (-)NCBICelera
Cytogenetic Map7q31NCBI
Ext1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541723,798,393 - 24,067,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541723,798,044 - 24,067,759 (-)NCBIChiLan1.0ChiLan1.0
EXT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18117,011,571 - 117,325,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8117,011,919 - 117,324,851 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08114,489,325 - 114,803,763 (-)NCBIMhudiblu_PPA_v0panPan3
EXT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11317,172,497 - 17,457,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1317,172,705 - 17,456,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1317,173,248 - 17,457,626 (-)NCBI
ROS_Cfam_1.01317,470,129 - 17,750,747 (-)NCBI
UMICH_Zoey_3.11317,205,173 - 17,489,568 (-)NCBI
UNSW_CanFamBas_1.01317,305,318 - 17,589,066 (-)NCBI
UU_Cfam_GSD_1.01317,549,676 - 17,834,137 (-)NCBI
Ext1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530320,877,114 - 21,140,365 (+)NCBI
SpeTri2.0NW_00493647028,303,213 - 28,566,470 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18112,435,733 - 112,751,301 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603927,547,084 - 27,862,637 (+)NCBIVero_WHO_p1.0
Ext1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476316,126,582 - 16,393,476 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 1 3 6 2 2 2
Low 2 3 2 2 2 17 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006593   ⟹   ENSSSCP00000006417
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl420,645,809 - 20,935,564 (+)Ensembl
RefSeq Acc Id: XM_001924980   ⟹   XP_001925015
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1420,645,002 - 20,935,769 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001925015 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC67995 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001925015   ⟸   XM_001924980
- UniProtKB: F1S274 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000006417   ⟸   ENSSSCT00000006593
Protein Domains
Exostosin   Glyco_transf_64


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006009 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006417 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006593 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.90.550.10 UniProtKB/TrEMBL
InterPro Exostosin UniProtKB/TrEMBL
  Exostosin-1 UniProtKB/TrEMBL
  Exostosin_GT47 UniProtKB/TrEMBL
  EXT_C UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
KEGG Report ssc:100157655 UniProtKB/TrEMBL
NCBI Gene EXT1 ENTREZGENE
PANTHER PTHR11062 UniProtKB/TrEMBL
  PTHR11062:SF97 UniProtKB/TrEMBL
Pfam Exostosin UniProtKB/TrEMBL
  Glyco_transf_64 UniProtKB/TrEMBL
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt F1S274 ENTREZGENE, UniProtKB/TrEMBL
  Q95KP6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87846 ENTREZGENE