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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:tumor necrosis factor-mediated signaling pathway
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Accession:GO:0033209 term browser browse the term
Definition:The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: tumor necrosis factor-mediated signalling pathway
 narrow_synonym: TNF-alpha-mediated signaling pathway;   tumor necrosis factor alpha-mediated signaling pathway
 related_synonym: adipocytokine signaling pathway


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tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN4 actinin alpha 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:35,742,758...35,825,321
Ensembl chr19:44,313,569...44,395,508 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G AIM2 absent in melanoma 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:134,413,232...134,540,344
Ensembl chr 1:138,210,946...138,221,753 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chr 1:131,282,514...131,326,535
Ensembl chr 1:135,112,040...135,159,299 		JBrowse link
G CARD14 caspase recruitment domain family member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:74,620,152...74,636,895
Ensembl chr17:80,342,810...80,369,707 		JBrowse link
G CD70 CD70 molecule involved_in IEA InterPro GO_REF:0000002 NCBI chr19:5,615,056...5,621,055
Ensembl chr19:6,535,559...6,542,310 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918 		JBrowse link
G COMMD7 COMM domain containing 7 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:28,990,068...29,031,630 JBrowse link
G EDA2R ectodysplasin A2 receptor involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:55,786,361...55,830,798
Ensembl chr  X:65,850,306...65,894,975 		JBrowse link
G EIF5A eukaryotic translation initiation factor 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,341,076...7,346,570
Ensembl chr17:7,327,363...7,333,270 		JBrowse link
G FAS Fas cell surface death receptor involved_in IEA GOC GO_REF:0000108 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FOXO3 forkhead box O3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,360,519...106,485,676
Ensembl chr 6:110,406,266...110,516,272 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G ILK integrin linked kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788 		JBrowse link
G JAK2 Janus kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G KRT18 keratin 18 acts_upstream_of_or_within ISO (PMID:10747083) MGI PMID:10747083 NCBI chr12:35,807,660...35,811,691
Ensembl chr12:36,587,149...36,591,196 		JBrowse link
G KRT8 keratin 8 acts_upstream_of_or_within ISO (PMID:10747083) MGI PMID:10747083 NCBI chr12:35,855,367...35,863,248
Ensembl chr12:36,634,582...36,642,564 		JBrowse link
G LIMS1 LIM zinc finger domain containing 1 involved_in ISO (PMID:21343177) CAFA PMID:21343177 NCBI chr2A:94,739,338...94,928,835 JBrowse link
G LOC100975471 suppression of tumorigenicity 18 protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,528,831...48,832,588
Ensembl chr 8:45,913,225...46,016,468 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in ISO (PMID:25038658) CAFA PMID:25038658 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NSMAF neutral sphingomyelinase activation associated factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:55,023,206...55,099,816
Ensembl chr 8:56,674,483...56,751,585 		JBrowse link
G PLVAP plasmalemma vesicle associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:16,840,151...16,864,334
Ensembl chr19:17,814,574...17,838,271 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,580,855...26,729,378
Ensembl chr 8:23,869,825...23,932,474 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,764,386...23,765,732
Ensembl chr16:31,571,363...31,573,828 		JBrowse link
G PYDC1 pyrin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,748,695...23,750,461
Ensembl chr16:31,588,129...31,588,398 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G RRAGA Ras related GTP binding A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:18,868,781...18,870,356
Ensembl chr 9:19,362,599...19,363,540 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280 		JBrowse link
G TIFA TRAF interacting protein with forkhead associated domain involved_in ISO (PMID:11798190) MGI PMID:11798190 NCBI chr 4:104,765,007...104,776,217 JBrowse link
G TMSB4X thymosin beta 4 X-linked acts_upstream_of_or_within_positive_effect ISO (PMID:21343177) CAFA PMID:21343177 NCBI chr  X:5,587,242...5,589,417 JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:3898078) Ensembl
MGI
TreeGrafter		 PMID:3898078 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr18:55,695,394...55,761,307
Ensembl chr18:59,034,770...59,075,044 		JBrowse link
G TNFRSF17 TNF receptor superfamily member 17 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:10,903,795...10,906,542
Ensembl chr16:12,333,254...12,336,219 		JBrowse link
G TNFRSF18 TNF receptor superfamily member 18 involved_in IEA GOC GO_REF:0000108
G TNFRSF1A TNF receptor superfamily member 1A involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:2152007|PMID:11588035) RGD
GOC
GOC
Ensembl
InterPro		 PMID:11588035 PMID:20967881 GO_REF:0000002 GO_REF:0000107 GO_REF:0000108 MGI:2152007 RGD:5130945 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B involved_in IEA GOC GO_REF:0000108 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G TNFRSF4 TNF receptor superfamily member 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2683815|PMID:14635034) GOC
GOC		 PMID:14635034 GO_REF:0000108 MGI:2683815 Ensembl chr 1:1,168,935...1,171,337 JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17442941), (PMID:18269914), (PMID:22437732) Ensembl
MGI		 PMID:17442941 PMID:18269914 PMID:22437732 GO_REF:0000107 NCBI chr13:23,750,835...23,784,740 JBrowse link
G TNFSF13B TNF superfamily member 13b involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:89,399,044...89,438,837
Ensembl chr13:108,536,617...108,574,296 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5306317|PMID:14521928) UniProt PMID:14521928 MGI:5306317
G TNFSF4 TNF superfamily member 4 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
G TP53 tumor protein p53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G TRADD TNFRSF1A associated via death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,499,881...47,506,220
Ensembl chr16:66,889,006...66,891,016 		JBrowse link
G TRAF1 TNF receptor associated factor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:92,030,205...92,056,776
Ensembl chr 9:120,376,592...120,402,948 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:10713108 PMID:20967881 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2298798 RGD:5130945 NCBI chr 9:107,938,935...107,984,797
Ensembl chr 9:136,917,358...136,955,331 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:83,392,689...83,530,974
Ensembl chr14:103,263,440...103,340,670 		JBrowse link
G TRAF3IP2 TRAF3 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:109,367,333...109,414,601
Ensembl chr 6:113,444,005...113,485,533 		JBrowse link
G TRAF4 TNF receptor associated factor 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:28,025,288...28,031,379
Ensembl chr17:28,531,867...28,536,994 		JBrowse link
G TRAF5 TNF receptor associated factor 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:186,889,615...186,938,416
Ensembl chr 1:191,754,652...191,802,075 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:36,457,633...36,483,616
Ensembl chr11:36,335,609...36,356,334 		JBrowse link
G TXNDC17 thioredoxin domain containing 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:6,678,375...6,680,902
Ensembl chr17:6,666,067...6,668,475 		JBrowse link
G UMOD uromodulin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28990932) Ensembl
MGI		 PMID:28990932 GO_REF:0000107 NCBI chr16:17,960,456...17,980,338
Ensembl chr16:20,430,085...20,449,121 		JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G APOA1 apolipoprotein A1 involved_in ISO (PMID:21571275) BHF-UCL PMID:21571275 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:59,618,530...59,623,612
Ensembl chr20:61,157,302...61,161,932 		JBrowse link
G CARD16 caspase recruitment domain family member 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:99,981,854...99,985,839
Ensembl chr11:103,467,368...103,468,288 		JBrowse link
G CARD8 caspase recruitment domain family member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:45,204,735...45,256,481
Ensembl chr19:53,798,967...53,850,328 		JBrowse link
G CCDC3 coiled-coil domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:12,901,592...13,104,528
Ensembl chr10:12,875,678...13,025,280 		JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548 		JBrowse link
G DICER1 dicer 1, ribonuclease III involved_in
acts_upstream_of		 IEA
ISO		 (PMID:26435691) Ensembl
ARUK-UCL		 PMID:26435691 GO_REF:0000107 NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:39,006,331...39,024,265 JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr13:113,968,843...114,009,562 JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,346,766...7,349,682
Ensembl chr17:7,333,571...7,335,871 		JBrowse link
G LOC100981494 histone H2B type 1-J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:26,958,944...26,966,117
Ensembl chr 6:27,627,323...27,627,703 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:44,345,623...44,401,358
Ensembl chr 5:45,920,125...45,973,937 		JBrowse link
G NLRP2B NLR family pyrin domain containing 2B involved_in ISO (PMID:24871464) UniProt PMID:24871464 NCBI chr  X:49,995,556...49,998,734 JBrowse link
G NOL3 nucleolar protein 3 involved_in ISO (MGI:5617337|PMID:24440909) UniProt PMID:24440909 MGI:5617337 NCBI chr16:47,516,156...47,521,441
Ensembl chr16:66,904,738...66,909,956 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:98,052,778...98,144,085
Ensembl chr12:101,457,885...101,548,058 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24113711)
(PMID:23950925)		 MGI
Ensembl		 PMID:23950925 PMID:24113711 GO_REF:0000107 NCBI chr11:61,824,463...61,834,930
Ensembl chr11:65,148,441...65,159,211 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr19:3,030,885...3,062,642
Ensembl chr19:3,982,555...4,015,167 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta acts_upstream_of
involved_in		 ISO
IEA		 (PMID:28159925) ARUK-UCL
Ensembl		 PMID:28159925 GO_REF:0000107 NCBI chr 8:30,099,605...30,126,917
Ensembl chr 8:27,288,263...27,302,606 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570 		JBrowse link
G PYDC1 pyrin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,748,695...23,750,461
Ensembl chr16:31,588,129...31,588,398 		JBrowse link
G PYDC2 pyrin domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:188,753,168...188,753,477
Ensembl chr 3:197,101,125...197,101,418 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:21,696,808...21,779,878
Ensembl chr17:22,035,643...22,069,546 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:48,426,036...48,525,265
Ensembl chr2B:165,820,833...165,896,438 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 9:55,536,627...55,690,472
Ensembl chr 9:67,886,421...68,021,189 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
G TRAIP TRAF interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:49,760,528...49,789,637
Ensembl chr 3:50,996,647...51,025,241 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:113,052,164...113,105,160
Ensembl chr  X:123,232,643...123,278,606 		JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G CASP1 caspase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CASP4 caspase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:99,883,353...99,909,185
Ensembl chr11:103,366,138...103,391,824 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chr 6:31,476,710...31,491,411 JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chr 6:31,488,882...31,491,412 JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818) ARUK-UCL PMID:22733818 MGI:6391873 NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385 		JBrowse link
G MMP8 matrix metallopeptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G RBM12 RNA binding motif protein 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:31,951,508...31,990,489
Ensembl chr20:33,069,932...33,108,547 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:107,938,935...107,984,797
Ensembl chr 9:136,917,358...136,955,331 		JBrowse link
G TRIM32 tripartite motif containing 32 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr 9:87,819,723...87,838,684
Ensembl chr 9:116,183,746...116,185,707 		JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:34,026,942...34,111,923
Ensembl chr 4:39,877,966...39,960,397 		JBrowse link
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr 8:114,489,325...114,803,763
Ensembl chr 8:117,011,919...117,324,851 		JBrowse link
G HIPK1 homeodomain interacting protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:88,579,603...88,627,988
Ensembl chr 1:123,633,134...123,677,714 		JBrowse link
G NKIRAS1 NFKB inhibitor interacting Ras like 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr 3:23,804,054...23,829,071
Ensembl chr 3:24,128,587...24,146,611 		JBrowse link
G NKIRAS2 NFKB inhibitor interacting Ras like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr17:15,290,435...15,299,060
Ensembl chr17:15,509,758...15,518,379 		JBrowse link
G OTULIN OTU deubiquitinase with linear linkage specificity involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:14,969,432...15,017,666
Ensembl chr 5:14,809,539...14,837,750 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17442941) Ensembl
MGI		 PMID:17442941 GO_REF:0000107 NCBI chr 1:121,900,224...121,911,513
Ensembl chr 1:113,758,691...113,768,714 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,764,386...23,765,732
Ensembl chr16:31,571,363...31,573,828 		JBrowse link
G SHARPIN SHANK associated RH domain interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:140,865,009...140,870,580
Ensembl chr 8:143,854,902...143,862,888 		JBrowse link
G SPATA2 spermatogenesis associated 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:46,245,560...46,257,656
Ensembl chr20:47,307,731...47,320,343 		JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:70,331,370...70,336,043
Ensembl chr17:75,883,329...75,886,481 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25220458) Ensembl
MGI		 PMID:25220458 GO_REF:0000107 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    cellular process 15499
      signal transduction 5443
        cell surface receptor signaling pathway 2632
          cytokine-mediated signaling pathway 442
            tumor necrosis factor-mediated signaling pathway 101
              negative regulation of tumor necrosis factor-mediated signaling pathway 28
              positive regulation of tumor necrosis factor-mediated signaling pathway 13
              regulation of tumor necrosis factor-mediated signaling pathway + 54
Path 2
Term Annotations click to browse term
  biological_process 16447
    response to stimulus 8504
      response to chemical 4401
        response to organic substance 3224
          response to cytokine 1054
            cellular response to cytokine stimulus 927
              cytokine-mediated signaling pathway 442
                tumor necrosis factor-mediated signaling pathway 101
                  negative regulation of tumor necrosis factor-mediated signaling pathway 28
                  positive regulation of tumor necrosis factor-mediated signaling pathway 13
                  regulation of tumor necrosis factor-mediated signaling pathway + 54
paths to the root