GAS6 (growth arrest specific 6) - Rat Genome Database

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Pathways
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Gene: GAS6 (growth arrest specific 6) Pan paniscus
Analyze
Symbol: GAS6
Name: growth arrest specific 6
RGD ID: 329346341
Description: ENCODES a protein that exhibits calcium ion binding (inferred); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (inferred); phosphatidylserine binding (inferred); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); apoptotic process (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth arrest-specific protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214115,287,501 - 115,335,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,980,770 - 114,028,247 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl13113,968,843 - 114,009,562 (-)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic cell clearance  (IEA,ISO)
apoptotic process  (IEA,ISO)
B cell chemotaxis  (IEA)
blood coagulation  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
cell surface receptor signaling pathway  (IEA)
cell-substrate adhesion  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to interferon-alpha  (IEA)
cellular response to starvation  (IEA,ISO)
cellular response to vitamin K  (IEA)
cellular response to xenobiotic stimulus  (IEA)
dendritic cell differentiation  (IEA)
enzyme-linked receptor protein signaling pathway  (IEA,ISO)
extracellular matrix assembly  (ISO)
fibroblast apoptotic process  (IEA,ISO)
fusion of virus membrane with host plasma membrane  (IEA)
hematopoietic stem cell migration to bone marrow  (IEA)
myeloid cell apoptotic process  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of biomineral tissue development  (IEA)
negative regulation of dendritic cell apoptotic process  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of fibroblast apoptotic process  (IEA,ISO)
negative regulation of interleukin-1 production  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of myeloid cell apoptotic process  (IEA,ISO)
negative regulation of oligodendrocyte apoptotic process  (IEA)
negative regulation of renal albumin absorption  (ISO)
negative regulation of tumor necrosis factor production  (IEA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
negative regulation of type II interferon production  (IEA)
neuron migration  (IEA,ISO)
phagocytosis  (IEA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of cytokine-mediated signaling pathway  (IEA)
positive regulation of dendritic cell chemotaxis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerular filtration  (ISO)
positive regulation of natural killer cell differentiation  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein export from nucleus  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of TOR signaling  (ISO)
protein localization to plasma membrane  (IEA)
receptor-mediated virion attachment to host cell  (IEA)
signal transduction  (IEA)
symbiont entry into host cell  (IEA)
viral genome replication  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GAS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214115,287,501 - 115,335,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,980,770 - 114,028,247 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl13113,968,843 - 114,009,562 (-)Ensemblpanpan1.1panPan2
GAS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,820,549 - 113,864,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,820,549 - 113,864,076 (-)EnsemblGRCh38hg38GRCh38
GRCh3713114,523,522 - 114,567,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,546,913 - 113,590,396 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413113,546,912 - 113,590,396NCBI
Celera1395,265,581 - 95,312,916 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,864,702 - 94,908,220 (+)NCBIHuRef
CHM1_113114,491,807 - 114,536,236 (-)NCBICHM1_1
T2T-CHM13v2.013113,029,283 - 113,074,357 (-)NCBIT2T-CHM13v2.0
Gas6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,515,374 - 13,544,535 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,515,374 - 13,544,490 (-)EnsemblGRCm39 Ensembl
GRCm38813,465,374 - 13,494,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,465,374 - 13,494,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,465,374 - 13,494,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,465,351 - 13,494,483 (-)NCBIMGSCv36mm8
Celera813,633,535 - 13,662,710 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.06NCBI
Gas6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,747,676 - 82,778,090 (+)NCBIGRCr8
mRatBN7.21676,045,430 - 76,075,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,045,426 - 76,075,904 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,326,082 - 81,356,495 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,779,051 - 84,809,465 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,027,812 - 80,058,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,213,364 - 81,243,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,213,364 - 81,243,757 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,701,559 - 80,732,410 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,900,159 - 80,930,929 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,900,528 - 80,930,916 (+)NCBI
Celera1673,852,900 - 73,883,275 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Gas6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404275,946 - 304,809 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955404276,397 - 303,864 (+)NCBIChiLan1.0ChiLan1.0
GAS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,975,196 - 61,005,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,974,849 - 61,005,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,684,745 - 60,717,508 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,659,911 - 61,692,783 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,659,911 - 61,692,635 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,097,815 - 61,130,605 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,099,052 - 61,131,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,131,260 - 61,164,234 (-)NCBIUU_Cfam_GSD_1.0
Gas6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,897,815 - 195,920,260 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647232,123 - 54,028 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647227,116 - 57,158 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,848,797 - 78,881,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,848,797 - 78,880,733 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,582,221 - 86,614,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103214855
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,720,871 - 91,762,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604648,879,389 - 48,960,473 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gas6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793385,812 - 410,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793385,846 - 410,934 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037852   ⟹   ENSPPAP00000015163
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13113,968,843 - 114,009,562 (-)Ensembl
RefSeq Acc Id: XM_055097068   ⟹   XP_054953043
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214115,287,501 - 115,335,117 (-)NCBI
NHGRI_mPanPan113113,980,770 - 114,028,247 (-)NCBI
RefSeq Acc Id: XM_055097069   ⟹   XP_054953044
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214115,287,501 - 115,335,105 (-)NCBI
NHGRI_mPanPan113113,980,770 - 114,028,190 (-)NCBI
RefSeq Acc Id: XM_063595988   ⟹   XP_063452058
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214115,287,501 - 115,335,105 (-)NCBI
RefSeq Acc Id: XM_063595989   ⟹   XP_063452059
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214115,287,501 - 115,335,090 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054953043 (Get FASTA)   NCBI Sequence Viewer  
  XP_054953044 (Get FASTA)   NCBI Sequence Viewer  
  XP_063452058 (Get FASTA)   NCBI Sequence Viewer  
  XP_063452059 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015163.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000015163   ⟸   ENSPPAT00000037852
RefSeq Acc Id: XP_054953043   ⟸   XM_055097068
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054953044   ⟸   XM_055097069
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063452058   ⟸   XM_063595988
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063452059   ⟸   XM_063595989
- Peptide Label: isoform X3
Protein Domains
EGF-like   Gla   Laminin G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030726 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037852.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Coagulation Factor IX UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro cEGF UniProtKB/TrEMBL
  Coagulation_fac-like_Gla_dom UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
NCBI Gene GAS6 ENTREZGENE
PANTHER GROWTH ARREST-SPECIFIC PROTEIN 6 UniProtKB/TrEMBL
  LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam cEGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
Superfamily-SCOP Concanavalin A-like lectins/glucanases UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  GLA-domain UniProtKB/TrEMBL
  Growth factor receptor domain UniProtKB/TrEMBL
UniProt A0A2R9AHY2_PANPA UniProtKB/TrEMBL