IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta) Pan paniscus
Analyze
Symbol: IKBKB
Name: inhibitor of nuclear factor kappa B kinase subunit beta
RGD ID: 11673399
Description: ENCODES a protein that exhibits ATP binding (ortholog); IkappaB kinase activity (ortholog); protein phosphatase binding (ortholog); INVOLVED IN B cell homeostasis (ortholog); integrin-mediated signaling pathway (ortholog); negative regulation of cytokine production involved in inflammatory response (ortholog); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); breast cancer (ortholog); Choroidal Neovascularization (ortholog); FOUND IN CD40 receptor complex (ortholog); cytoplasm (ortholog); cytoplasmic side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,723,875 - 60,784,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,441,096 - 36,501,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,515,613 - 41,576,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,960,594 - 39,020,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,960,594 - 39,020,971 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IKBKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,723,875 - 60,784,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,441,096 - 36,501,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,515,613 - 41,576,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,960,594 - 39,020,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,960,594 - 39,020,971 (+)Ensemblpanpan1.1panPan2
IKBKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,271,302 - 42,332,460 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,271,302 - 42,332,460 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,128,820 - 42,189,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,247,986 - 42,309,122 (+)NCBINCBI36Build 36hg18NCBI36
Build 34842,247,985 - 42,309,122NCBI
Celera841,077,798 - 41,138,835 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,656,604 - 40,717,697 (+)NCBIHuRef
CHM1_1842,177,451 - 42,238,764 (+)NCBICHM1_1
T2T-CHM13v2.0842,545,654 - 42,606,501 (+)NCBIT2T-CHM13v2.0
Ikbkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,149,228 - 23,196,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,149,228 - 23,196,605 (-)EnsemblGRCm39 Ensembl
GRCm38822,659,205 - 22,706,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,659,212 - 22,706,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,769,677 - 23,817,055 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,125,308 - 24,172,108 (-)NCBIMGSCv36mm8
Celera824,149,472 - 24,196,863 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Ikbkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,021,968 - 76,075,717 (+)NCBIGRCr8
mRatBN7.21669,319,487 - 69,373,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,593,277 - 74,646,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,025,765 - 78,078,546 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,274,913 - 73,327,717 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,177,233 - 74,230,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,809,854 - 73,863,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,804,730 - 73,858,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,805,346 - 73,858,348 (+)NCBI
Celera1667,214,025 - 67,266,348 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Ikbkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536612,774 - 658,647 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955536611,965 - 658,647 (-)NCBIChiLan1.0ChiLan1.0
IKBKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,359,551 - 23,419,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,359,813 - 23,419,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,864,109 - 23,923,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,108,158 - 25,167,347 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,108,158 - 25,167,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,479,268 - 23,538,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,042,615 - 24,101,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,093,332 - 24,152,694 (-)NCBIUU_Cfam_GSD_1.0
Ikbkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,401,726 - 46,450,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785356,168 - 406,773 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936785358,128 - 406,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,289,690 - 11,348,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,289,607 - 11,348,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,063,170 - 13,101,270 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IKBKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,267,532 - 40,325,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,268,079 - 40,326,381 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,461,878 - 1,520,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780923,744 - 970,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624780922,524 - 978,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000044911   ⟹   ENSPPAP00000022104
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,960,594 - 39,020,971 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044928   ⟹   ENSPPAP00000022121
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,961,315 - 39,020,971 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044931   ⟹   ENSPPAP00000022124
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,961,336 - 39,020,971 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044940   ⟹   ENSPPAP00000022133
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,961,354 - 39,019,951 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044942   ⟹   ENSPPAP00000022135
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,961,354 - 39,010,884 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044947   ⟹   ENSPPAP00000022140
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,961,354 - 38,998,407 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044954   ⟹   ENSPPAP00000022147
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,961,354 - 38,994,106 (+)Ensembl
RefSeq Acc Id: XM_008976912   ⟹   XP_008975160
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,875 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,096 - 36,501,335 (+)NCBI
Mhudiblu_PPA_v0841,515,614 - 41,576,229 (+)NCBI
PanPan1.1838,960,679 - 39,020,971 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024929847   ⟹   XP_024785615
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,941 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,104 - 36,501,335 (+)NCBI
Mhudiblu_PPA_v0841,515,613 - 41,576,229 (+)NCBI
PanPan1.1838,960,679 - 39,018,658 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034966007   ⟹   XP_034821898
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,875 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,096 - 36,501,335 (+)NCBI
Mhudiblu_PPA_v0841,516,371 - 41,576,229 (+)NCBI
RefSeq Acc Id: XM_034966008   ⟹   XP_034821899
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,941 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,104 - 36,501,335 (+)NCBI
Mhudiblu_PPA_v0841,515,614 - 41,576,229 (+)NCBI
RefSeq Acc Id: XM_034966010   ⟹   XP_034821901
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,875 - 60,778,684 (+)NCBI
NHGRI_mPanPan1836,441,096 - 36,495,826 (+)NCBI
Mhudiblu_PPA_v0841,516,383 - 41,570,293 (+)NCBI
RefSeq Acc Id: XM_055116512   ⟹   XP_054972487
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,941 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,098 - 36,501,335 (+)NCBI
RefSeq Acc Id: XM_055116513   ⟹   XP_054972488
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,943 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,098 - 36,501,335 (+)NCBI
RefSeq Acc Id: XM_057303000   ⟹   XP_057158983
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,941 - 60,784,734 (+)NCBI
NHGRI_mPanPan1836,441,104 - 36,501,335 (+)NCBI
RefSeq Acc Id: XM_063607173   ⟹   XP_063463243
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,723,953 - 60,784,734 (+)NCBI
RefSeq Acc Id: XP_008975160   ⟸   XM_008976912
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B3R9 (UniProtKB/TrEMBL),   A0A2R9AXR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024785615   ⟸   XM_024929847
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034821899   ⟸   XM_034966008
- Peptide Label: isoform X5
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034821898   ⟸   XM_034966007
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034821901   ⟸   XM_034966010
- Peptide Label: isoform X7
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000022121   ⟸   ENSPPAT00000044928
Ensembl Acc Id: ENSPPAP00000022124   ⟸   ENSPPAT00000044931
Ensembl Acc Id: ENSPPAP00000022135   ⟸   ENSPPAT00000044942
Ensembl Acc Id: ENSPPAP00000022133   ⟸   ENSPPAT00000044940
Ensembl Acc Id: ENSPPAP00000022140   ⟸   ENSPPAT00000044947
Ensembl Acc Id: ENSPPAP00000022147   ⟸   ENSPPAT00000044954
Ensembl Acc Id: ENSPPAP00000022104   ⟸   ENSPPAT00000044911
RefSeq Acc Id: XP_054972487   ⟸   XM_055116512
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054972488   ⟸   XM_055116513
- Peptide Label: isoform X9
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057158983   ⟸   XM_057303000
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AXT3 (UniProtKB/TrEMBL),   A0A2R9AXR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063463243   ⟸   XM_063607173
- Peptide Label: isoform X8
- UniProtKB: A0A2R9AXR5 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   Ubiquitin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034251 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044911.1 UniProtKB/TrEMBL
  ENSPPAT00000044928.1 UniProtKB/TrEMBL
  ENSPPAT00000044931.1 UniProtKB/TrEMBL
  ENSPPAT00000044940.1 UniProtKB/TrEMBL
  ENSPPAT00000044942.1 UniProtKB/TrEMBL
  ENSPPAT00000044947.1 UniProtKB/TrEMBL
  ENSPPAT00000044954.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/TrEMBL
  6.10.250.2110 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/TrEMBL
  IKK UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report pps:100989390 UniProtKB/TrEMBL
NCBI Gene IKBKB ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA UniProtKB/TrEMBL
Pfam IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART IKKbetaNEMObind UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9AXR5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AXT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AY23_PANPA UniProtKB/TrEMBL
  A0A2R9AY29_PANPA UniProtKB/TrEMBL
  A0A2R9AYH1_PANPA UniProtKB/TrEMBL
  A0A2R9B1W6_PANPA UniProtKB/TrEMBL
  A0A2R9B3R9 ENTREZGENE, UniProtKB/TrEMBL