UMOD (uromodulin) - Rat Genome Database

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Gene: UMOD (uromodulin) Pan paniscus
Analyze
Symbol: UMOD
Name: uromodulin
RGD ID: 11678433
Description: ENCODES a protein that exhibits calcium ion binding (inferred); IgG binding (inferred); INVOLVED IN apoptotic process (ortholog); apoptotic signaling pathway (ortholog); autophagy (ortholog); ASSOCIATED WITH Autosomal Dominant Tubulointerstitial Kidney Disease 1 (ortholog); Autosomal Dominant Tubulointerstitial Kidney Disease 2 (ortholog); chronic kidney disease (ortholog); FOUND IN apical part of cell (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,594,038 - 21,613,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,115,698 - 26,135,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,960,456 - 17,980,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11620,429,822 - 20,449,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1620,430,085 - 20,449,121 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA)
apoptotic process  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
autophagy  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
cellular response to stress  (IEA,ISO)
cellular response to unfolded protein  (IEA,ISO)
chaperone-mediated protein folding  (IEA,ISO)
chemical homeostasis  (IEA,ISO)
chloride ion homeostasis  (IEA,ISO)
citric acid secretion  (IEA,ISO)
collecting duct development  (IEA,ISO)
connective tissue replacement  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
endoplasmic reticulum organization  (IEA,ISO)
ERAD pathway  (IEA,ISO)
gene expression  (IEA,ISO)
glomerular filtration  (IEA,ISO)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA)
inflammatory response  (IEA,ISO)
innate immune response  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular chloride ion homeostasis  (IEA,ISO)
intracellular phosphate ion homeostasis  (IEA,ISO)
intracellular sodium ion homeostasis  (IEA,ISO)
juxtaglomerular apparatus development  (IEA,ISO)
kidney development  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA)
lipid metabolic process  (IEA,ISO)
loop of Henle development  (IEA,ISO)
metanephric ascending thin limb development  (IEA)
metanephric distal convoluted tubule development  (IEA)
metanephric thick ascending limb development  (IEA)
micturition  (IEA,ISO)
monoatomic ion homeostasis  (IEA)
multicellular organismal response to stress  (IEA,ISO)
multicellular organismal-level homeostasis  (IEA,ISO)
multicellular organismal-level water homeostasis  (IEA,ISO)
neutrophil migration  (IEA)
organ or tissue specific immune response  (IEA,ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphate ion homeostasis  (IEA,ISO)
potassium ion homeostasis  (IEA,ISO)
protein localization to vacuole  (IEA,ISO)
protein phosphorylation  (ISO)
protein transport into plasma membrane raft  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of protein transport  (IEA,ISO)
regulation of urine volume  (IEA,ISO)
renal sodium ion absorption  (IEA,ISO)
renal urate salt excretion  (IEA,ISO)
renal water homeostasis  (IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to unfolded protein  (IEA,ISO)
response to water deprivation  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
RNA splicing  (IEA,ISO)
sodium ion homeostasis  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
urate transport  (IEA,ISO)
urea transmembrane transport  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UMOD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21821,594,038 - 21,613,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,115,698 - 26,135,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,960,456 - 17,980,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11620,429,822 - 20,449,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1620,430,085 - 20,449,121 (-)Ensemblpanpan1.1panPan2
UMOD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381620,333,051 - 20,356,301 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1620,333,051 - 20,356,301 (-)EnsemblGRCh38hg38GRCh38
GRCh371620,344,373 - 20,364,037 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361620,251,874 - 20,271,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 341620,251,874 - 20,271,538NCBI
Celera1619,493,555 - 19,513,244 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,881,007 - 18,900,856 (-)NCBIHuRef
CHM1_11620,432,269 - 20,452,397 (-)NCBICHM1_1
T2T-CHM13v2.01620,264,004 - 20,287,315 (-)NCBIT2T-CHM13v2.0
Umod
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,061,931 - 119,078,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,061,934 - 119,078,505 (-)EnsemblGRCm39 Ensembl
GRCm387119,462,708 - 119,479,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7119,462,711 - 119,479,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv377126,606,380 - 126,622,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,254,013 - 119,270,404 (-)NCBIMGSCv36mm8
Celera7119,386,384 - 119,402,859 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map763.88NCBI
Umod
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,247,676 - 183,261,665 (-)NCBIGRCr8
mRatBN7.21173,816,341 - 173,829,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,816,339 - 173,830,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,127,287 - 182,141,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,313,389 - 189,327,107 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,048,615 - 182,062,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,186,027 - 189,199,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,186,026 - 189,199,376 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,127,939 - 196,141,822 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,729,212 - 177,742,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11177,868,457 - 177,881,798 (-)NCBI
Celera1171,569,071 - 171,582,409 (-)NCBICelera
Cytogenetic Map1q35NCBI
Umod
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554423,985,308 - 3,999,598 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554423,986,936 - 4,001,155 (-)NCBIChiLan1.0ChiLan1.0
UMOD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,991,459 - 25,006,735 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,991,459 - 25,006,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha626,355,935 - 26,369,584 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0625,145,508 - 25,160,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl625,145,508 - 25,160,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,946,350 - 24,961,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,841,732 - 24,857,098 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0625,229,622 - 25,244,770 (+)NCBIUU_Cfam_GSD_1.0
Umod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344117,735,331 - 117,748,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365015,833,391 - 5,846,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365015,833,391 - 5,846,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UMOD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl325,473,162 - 25,492,278 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1325,473,048 - 25,492,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,195,083 - 26,205,810 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UMOD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1518,620,927 - 18,641,312 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl518,619,895 - 18,638,719 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606811,265,375 - 11,285,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Umod
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,640,214 - 3,652,324 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,639,955 - 3,654,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000052479   ⟹   ENSPPAP00000029629
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1620,430,085 - 20,449,121 (-)Ensembl
RefSeq Acc Id: XM_003830545   ⟹   XP_003830593
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21821,594,038 - 21,613,794 (-)NCBI
NHGRI_mPanPan11626,115,698 - 26,135,439 (-)NCBI
Mhudiblu_PPA_v01617,960,456 - 17,980,338 (+)NCBI
PanPan1.11620,429,822 - 20,449,266 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055100230   ⟹   XP_054956205
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21821,594,038 - 21,613,731 (-)NCBI
NHGRI_mPanPan11626,115,698 - 26,135,376 (-)NCBI
RefSeq Acc Id: XM_055100231   ⟹   XP_054956206
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21821,594,038 - 21,613,692 (-)NCBI
NHGRI_mPanPan11626,115,698 - 26,135,337 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003830593 (Get FASTA)   NCBI Sequence Viewer  
  XP_054956205 (Get FASTA)   NCBI Sequence Viewer  
  XP_054956206 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000029629.1
RefSeq Acc Id: XP_003830593   ⟸   XM_003830545
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BIY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000029629   ⟸   ENSPPAT00000052479
RefSeq Acc Id: XP_054956205   ⟸   XM_055100230
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BIY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054956206   ⟸   XM_055100231
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BIY0 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   ZP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037826 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052479.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  ZP-C UniProtKB/TrEMBL
  ZP_chr UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/TrEMBL
NCBI Gene UMOD ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/TrEMBL
  UROMODULIN UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/TrEMBL
PRINTS ZPELLUCIDA UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  ZP_1 UniProtKB/TrEMBL
  ZP_2 UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SM00241 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A2R9BIY0 ENTREZGENE, UniProtKB/TrEMBL