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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benidipine
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Accession:CHEBI:135806 term browser browse the term
Synonyms:related_synonym: Formula=C28H31N3O6;   InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26?/m1/s1;   InChIKey=QZVNQOLPLYWLHQ-GEPVFLLWSA-N;   SMILES=C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3C(C(C(OC)=O)=C(NC3C)C)C4=CC([N+](=O)[O-])=CC=C4;   benidipine HCl;   benidipine hydrochloride;   coniel
 xref: CAS:105979-17-7;   Drug_Central:3880
 xref_mesh: MESH:C061004


show annotations for term's descendants           Sort by:
benidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G AGT angiotensinogen multiple interactions EXP [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]; benidipine inhibits the reaction [AGT protein results in increased uptake of Calcium] CTD PMID:18331727 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AHR aryl hydrocarbon receptor increases activity EXP benidipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AR androgen receptor decreases activity EXP benidipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein] CTD PMID:25269373 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:25269373 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CKB creatine kinase B multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:25269373 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833 		JBrowse link
G CKM creatine kinase, M-type multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:25269373 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain affects expression ISO benidipine affects the expression of COL4A1 mRNA CTD PMID:15721868 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157 		JBrowse link
G CRP C-reactive protein multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CRP protein] CTD PMID:25269373 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 multiple interactions EXP benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]; benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA] CTD PMID:18331727 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 multiple interactions EXP benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA] CTD PMID:18331727 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
increases expression		 EXP benidipine results in decreased activity of CYP1A1 protein
benidipine results in increased expression of CYP1A1 mRNA		 CTD PMID:10805063 PMID:27732883 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP benidipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression EXP benidipine results in increased expression of CYP2A6 mRNA; benidipine results in increased expression of CYP2A6 protein CTD PMID:27732883 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP benidipine results in increased expression of CYP2B6 mRNA; benidipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP benidipine results in decreased activity of CYP2C19 protein CTD PMID:10805063 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP benidipine results in decreased activity of CYP2C9 protein CTD PMID:10805063 PMID:27732883 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP benidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 decreases activity EXP benidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
multiple interactions
increases expression		 EXP benidipine results in decreased activity of CYP3A4 protein
benidipine results in increased expression of and results in decreased activity of CYP3A4 protein
benidipine results in increased expression of CYP3A4 mRNA		 CTD PMID:10805063 PMID:27732883 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 affects expression ISO benidipine affects the expression of DYNLL1 mRNA CTD PMID:15721868 NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493 		JBrowse link
G ESR1 estrogen receptor 1 decreases activity EXP benidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in decreased activity of GPX1 protein] CTD PMID:25269373 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] CTD PMID:25269373 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in decreased activity of GSTA1 protein] CTD PMID:25269373 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G LDHA lactate dehydrogenase A multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of LDHA protein] CTD PMID:25269373 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808 		JBrowse link
G NPPB natriuretic peptide B affects expression ISO benidipine affects the expression of NPPB mRNA CTD PMID:15721868 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 increases activity
decreases activity
multiple interactions		 EXP benidipine results in increased activity of NR1H4 protein
benidipine results in decreased activity of NR1H4 protein
benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; benidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]		 CTD PMID:25257666 PMID:27773686 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP benidipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO benidipine inhibits the reaction [Isoproterenol results in decreased activity of SOD1 protein] CTD PMID:25269373 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      atom 26016
        nonmetal atom 25505
          nitrogen atom 22541
            nitrogen molecular entity 22541
              organonitrogen compound 21934
                organonitrogen heterocyclic compound 20345
                  piperidines 8196
                    benidipine 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  organic heteromonocyclic compound 19228
                                    piperidines 8196
                                      benidipine 32
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