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butein - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:butein
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Accession:CHEBI:3237 term browser browse the term
Definition:A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
Synonyms:exact_synonym: (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one;   (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
 related_synonym: (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one;   (E)-2',3,4,4'-terahydroxychalcone;   2',3,4,4'-Tetrahydroxychalcone;   Formula=C15H12O5;   InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+;   InChIKey=AYMYWHCQALZEGT-ORCRQEGFSA-N;   SMILES=OC1=CC(O)=C(C=C1)C(=O)\\C=C\\C1=CC(O)=C(O)C=C1
 xref: CAS:487-52-5;   Chemspider:4444634;   FooDB:FDB000082;   KEGG:C08578;   KNApSAcK:C00006941;   LINCS:LSM-42896;   LIPID_MAPS_instance:LMPK12120111
 xref_mesh: MESH:C040918
 xref: MetaCyc:BUTEIN;   PDBeChem:BUN;   PMID:12939617;   PMID:19643530;   PMID:20515942;   PMID:20681544;   PMID:20696233;   PMID:20826149;   PMID:21131551;   PMID:21170936;   PMID:21212525;   PMID:21770460;   PMID:21964506;   PMID:22114764;   PMID:22155143;   PMID:22180353;   PMID:22185775;   PMID:22245810;   PMID:26081470;   PMID:29258953;   PMID:30344763;   PMID:31665136;   PMID:32033283;   PMID:32181410;   PMID:32325749;   PMID:32642916;   PMID:32663368;   PMID:33209079;   PMID:33294263;   PMID:33325610;   PMID:34271434;   PMID:34481015;   Reaxys:2056928;   Wikipedia:Butein

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butein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions 		ISO butein results in decreased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [butein results in decreased phosphorylation of AKT1 protein] 		CTD PMID:20696233 PMID:35130734 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein increases expression EXP butein results in increased expression of BAX protein CTD PMID:11055382 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression EXP butein results in decreased expression of BCL2 protein CTD PMID:11055382 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression EXP butein results in decreased expression of BCL2L1 protein CTD PMID:11055382 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions 		ISO butein results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [butein results in increased activity of CASP3 protein] 		CTD PMID:24931875 PMID:35130734 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases activity ISO butein results in increased activity of CASP8 protein CTD PMID:35130734 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity ISO butein results in increased activity of CASP9 protein CTD PMID:35130734 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO butein affects the reaction [IL6 protein affects the expression of CDH1 protein] CTD PMID:35130734 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II decreases activity ISO butein results in decreased activity of DIO2 protein CTD PMID:17327447 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO butein results in decreased expression of GPX4 protein CTD PMID:35130734 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [butein results in increased expression of HMOX1 protein] inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]; [butein results in increased expression of HMOX1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [tin protoporphyrin IX results in decreased expression of and results in decreased activity of HMOX1 protein] inhibits the reaction [butein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]; butein results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [butein results in increased expression of HMOX1 protein] CTD PMID:23318726 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO butein affects the reaction [IL6 protein affects the expression of CDH1 protein]; butein affects the reaction [IL6 protein affects the expression of MMP2 protein]; butein affects the reaction [IL6 protein affects the expression of MMP9 protein]; butein affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein] CTD PMID:35130734 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
multiple interactions 		ISO butein results in increased lipidation of MAP1LC3B protein
Acetylcysteine inhibits the reaction [butein results in increased lipidation of MAP1LC3B protein]; MK 2206 promotes the reaction [butein results in increased lipidation of MAP1LC3B protein]; pyrazolanthrone inhibits the reaction [butein results in increased lipidation of MAP1LC3B protein] 		CTD PMID:35130734 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions 		ISO butein results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [butein results in increased phosphorylation of MAPK8 protein] 		CTD PMID:35130734 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO butein affects the reaction [IL6 protein affects the expression of MMP2 protein] CTD PMID:35130734 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression 		ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butein results in decreased expression of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [butein results in decreased expression of MMP9 protein]; Bortezomib promotes the reaction [butein results in decreased expression of MMP9 protein]; butein affects the reaction [IL6 protein affects the expression of MMP9 protein]; butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; prolinedithiocarbamate promotes the reaction [butein results in decreased expression of MMP9 protein]
butein results in decreased expression of MMP9 mRNA; butein results in decreased expression of MMP9 protein 		CTD PMID:20696233 PMID:35130734 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation 		ISO Acetylcysteine inhibits the reaction [butein results in decreased phosphorylation of MTOR protein] CTD PMID:35130734 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization ISO butein affects the localization of NFE2L2 protein CTD PMID:23318726 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 affects localization ISO butein affects the localization of NFKB1 protein CTD PMID:20696233 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO butein results in increased activity of NR1I2 protein CTD PMID:29933105 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO butein results in increased cleavage of PARP1 protein CTD PMID:24931875 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pttg1 pituitary tumor-transforming gene 1 decreases expression
decreases response to substance 		ISO butein results in decreased expression of PTTG1 protein
PTTG1 protein results in decreased susceptibility to butein 		CTD PMID:24931875 NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization ISO butein affects the localization of RELA protein CTD PMID:20696233 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sirt1 sirtuin 1 increases activity ISO butein results in increased activity of SIRT1 protein CTD PMID:17327447 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO butein affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein] CTD PMID:35130734 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO butein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:20696233 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO butein results in decreased expression of VEGFA mRNA CTD PMID:20696233 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
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  CHEBI ontology 22412
    role 22396
      chemical role 21633
        antioxidant 16544
          butein 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 22412
    subatomic particle 22406
      composite particle 22406
        hadron 22406
          baryon 22406
            nucleon 22406
              atomic nucleus 22406
                atom 22406
                  main group element atom 22292
                    p-block element atom 22292
                      carbon group element atom 22094
                        carbon atom 22027
                          organic molecular entity 22027
                            heteroorganic entity 21671
                              organochalcogen compound 21167
                                organooxygen compound 21008
                                  carbonyl compound 20342
                                    ketone 18076
                                      alpha,beta-unsaturated ketone 10092
                                        enone 10092
                                          chalcones 957
                                            butein 27
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