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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chalcones
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Accession:CHEBI:23086 term browser browse the term
Definition:A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
Synonyms:related_synonym: chalconoid;   chalconoids
 xref: KEGG:C15589
 xref_mesh: MESH:D047188


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chalcones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO BCL2 protein inhibits the reaction [Chalcones analog results in increased expression of BAX protein] CTD PMID:30576621 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Chalcones analog results in decreased expression of BCL2 protein; Chalcones results in decreased expression of BCL2 protein
BCL2 protein inhibits the reaction [Chalcones analog results in decreased expression of BID protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP4 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP6 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP7 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of PARP1 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased expression of BAX protein]
CTD PMID:23562496, PMID:30576621 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression
ISO BCL2 protein inhibits the reaction [Chalcones analog results in decreased expression of BID protein] CTD PMID:30576621 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions ISO BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP3 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:30576621 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases cleavage
multiple interactions
ISO Chalcones analog results in increased cleavage of CASP4 protein
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP4 protein]
CTD PMID:30576621 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 multiple interactions
increases cleavage
ISO BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP6 protein] CTD PMID:30576621 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 increases cleavage
multiple interactions
ISO Chalcones analog results in increased cleavage of CASP7 protein
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP7 protein]
CTD PMID:30576621 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:30576621 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP9 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:30576621 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity EXP Chalcones analog results in increased activity of CAT protein CTD PMID:23963778 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Chalcones analog results in increased activity of GSR protein CTD PMID:23963778 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:22410118 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP Chalcones analog results in decreased expression of KEAP1 protein CTD PMID:23963778 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO Chalcones results in decreased expression of MMP9 mRNA
Chalcones results in decreased expression of and results in decreased activity of MMP9 protein
CTD PMID:23562496 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:22410118 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression EXP Chalcones analog results in increased expression of NFE2L2 protein CTD PMID:23963778 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Chalcones analog results in increased expression of NQO1 protein CTD PMID:23963778 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of PARP1 protein] CTD PMID:30576621 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions EXP Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PECAM1 protein] CTD PMID:22410118 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid affects the localization of RELA protein] CTD PMID:22410118 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Chalcones inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
CTD PMID:18720166, PMID:22410118 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Chalcones analog results in increased expression of UGT1A1 protein CTD PMID:23963778 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]
CTD PMID:31029725 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein
CTD PMID:31029725 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31029725 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA] CTD PMID:31029725 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:31029725 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:31029725 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]
CTD PMID:31029725 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]
CTD PMID:31029725 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein] CTD PMID:31029725 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]
CTD PMID:31029725 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]
CTD PMID:31029725 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA] CTD PMID:31029725 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
2',4,4',6'-tetrahydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of naringenin chalcone CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of naringenin chalcone CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of naringenin chalcone CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
2'-hydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO 2'-hydroxychalcone results in decreased activity of CYP1A1 protein
2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]
CTD PMID:15596260 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
multiple interactions
ISO 2'-hydroxychalcone results in decreased activity of CYP1B1 protein
2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]
CTD PMID:15596260 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 2'-hydroxychalcone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
4'-hydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP 4'-hydroxychalcone binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO 4'-hydroxychalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
4-hydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP 4-hydroxychalcone binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor affects binding EXP 4-hydroxychalcone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
affects chemical synthesis
ISO
EXP
4-hydroxychalcone results in decreased activity of CYP1A1 protein
CYP1A1 protein affects the chemical synthesis of 4-hydroxychalcone
CTD PMID:15596260, PMID:15863696 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects chemical synthesis EXP CYP1A2 protein affects the chemical synthesis of 4-hydroxychalcone CTD PMID:15863696 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO 4-hydroxychalcone results in decreased activity of CYP1B1 protein CTD PMID:15596260 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects chemical synthesis EXP CYP2C6V1 protein affects the chemical synthesis of 4-hydroxychalcone CTD PMID:15863696 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO 4-hydroxychalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
butein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO butein results in decreased phosphorylation of AKT1 protein CTD PMID:20696233 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO butein results in increased expression of BAX protein CTD PMID:11055382 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO butein results in decreased expression of BCL2 protein CTD PMID:11055382 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO butein results in decreased expression of BCL2L1 protein CTD PMID:11055382 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO butein results in increased activity of CASP3 protein CTD PMID:24931875 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO butein results in decreased activity of DIO2 protein CTD PMID:17327447 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [butein results in increased expression of HMOX1 protein] inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]; [butein results in increased expression of HMOX1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [tin protoporphyrin IX results in decreased expression of and results in decreased activity of HMOX1 protein] inhibits the reaction [butein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]; butein results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [butein results in increased expression of HMOX1 protein] CTD PMID:23318726 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butein results in decreased expression of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [butein results in decreased expression of MMP9 protein]; Bortezomib promotes the reaction [butein results in decreased expression of MMP9 protein]; butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; prolinedithiocarbamate promotes the reaction [butein results in decreased expression of MMP9 protein]
butein results in decreased expression of MMP9 mRNA; butein results in decreased expression of MMP9 protein
CTD PMID:20696233 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO butein affects the localization of NFE2L2 protein CTD PMID:23318726 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO butein affects the localization of NFKB1 protein CTD PMID:20696233 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO butein results in increased activity of NR1I2 protein CTD PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO butein results in increased cleavage of PARP1 protein CTD PMID:24931875 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression
decreases response to substance
ISO butein results in decreased expression of PTTG1 protein
PTTG1 protein results in decreased susceptibility to butein
CTD PMID:24931875 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO butein affects the localization of RELA protein CTD PMID:20696233 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 increases activity ISO butein results in increased activity of SIRT1 protein CTD PMID:17327447 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO butein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:20696233 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO butein results in decreased expression of VEGFA mRNA CTD PMID:20696233 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
chalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Chalcone binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor affects binding EXP Chalcone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Chalcone results in decreased activity of CA1 protein CTD PMID:30431690 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Chalcone results in decreased activity of CA2 protein CTD PMID:30431690 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO Chalcone results in increased cleavage of CASP3 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]
CTD PMID:20620131 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Chalcone results in increased cleavage of CASP8 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]
CTD PMID:20620131 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO Chalcone results in increased cleavage of CASP9 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]
CTD PMID:20620131 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation EXP CYP1A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation EXP CYP1A2 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation EXP CYP2C6V1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chalcone analog results in increased expression of GCLM mRNA; Chalcone analog results in increased expression of GCLM protein CTD PMID:31299238 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hat1 histone acetyltransferase 1 decreases activity ISO Chalcone analog results in decreased activity of HAT1 protein CTD PMID:22155221 NCBI chr 3:58,022,395...58,070,067
Ensembl chr 3:58,022,238...58,070,068
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22155221 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22155221 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155221 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22155221 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:22155221 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
multiple interactions
ISO MYC protein affects the susceptibility to Chalcone
Chalcone promotes the reaction [MYC protein results in increased abundance of Reactive Oxygen Species]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]
CTD PMID:20620131 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Chalcone analog results in decreased ubiquitination of and results in decreased degradation of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione] CTD PMID:31299238 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22155221 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155221 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Chalcone analog results in increased expression of NQO1 mRNA; Chalcone analog results in increased expression of NQO1 protein CTD PMID:31299238 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Chalcone results in increased cleavage of PARP1 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]
CTD PMID:20620131 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Chalcone analog results in increased expression of PPARG mRNA CTD PMID:28528971 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of Chalcone CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased phosphorylation of RELA protein] which results in increased acetylation of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22155221 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Chalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22155221 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
flavokawain B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO flavokawain B results in decreased phosphorylation of AKT1 protein
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]
CTD PMID:30025493 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein] CTD PMID:30025493 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 multiple interactions
affects response to substance
ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 affects response to substance
multiple interactions
ISO ATG7 protein affects the susceptibility to flavokawain B
[ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD PMID:30025493 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein CTD PMID:30025493 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein CTD PMID:30025493 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO flavokawain B results in increased phosphorylation of EIF2AK3 protein CTD PMID:30025493 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO flavokawain B results in increased phosphorylation of EIF2S1 protein CTD PMID:30025493 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
increases expression
ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein
flavokawain B results in increased expression of GLB1 protein
CTD PMID:30025493 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO flavokawain B results in increased expression of HSPA5 protein CTD PMID:30025493 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein CTD PMID:30025493 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein] CTD PMID:30025493 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein CTD PMID:30025493 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO flavokawain B results in decreased phosphorylation of RPS6KB1 protein
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:30025493 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO flavokawain B results in increased expression of SQSTM1 protein CTD PMID:30025493 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression
ISO ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30025493 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
isobavachalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
EXP isobavachalcone results in decreased activity of CYP2E1 protein
isobavachalcone inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]
CTD PMID:31870919 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
EXP isobavachalcone inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]
isobavachalcone results in decreased activity of CYP3A4 protein
CTD PMID:31870919 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO isobavachalcone results in increased cleavage of PARP1 protein CTD PMID:30890322 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
isoliquiritigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP isoliquiritigenin binds to AFP protein CTD PMID:23013281 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein] CTD PMID:25110319 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
decreases phosphorylation
ISO AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]
isoliquiritigenin results in decreased phosphorylation of AKT1 protein
CTD PMID:23747687, PMID:25094029, PMID:27117918 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arg1 arginase 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein] CTD PMID:25026504 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein CTD PMID:11055382, PMID:27702603 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases phosphorylation ISO isoliquiritigenin results in decreased phosphorylation of BCL2 protein CTD PMID:23747687 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
decreases phosphorylation
ISO isoliquiritigenin results in decreased expression of BCL2L1 protein
isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein
CTD PMID:11055382, PMID:15729620, PMID:23747687 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO isoliquiritigenin results in decreased expression of BIRC2 protein CTD PMID:15729620 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO isoliquiritigenin results in decreased expression of BIRC3 protein CTD PMID:15729620 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein
isoliquiritigenin results in increased activity of CASP3 protein
CTD PMID:15729620, PMID:16158945, PMID:23747687, PMID:25094029 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO isoliquiritigenin results in increased activity of CASP8 protein CTD PMID:16158945 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein
isoliquiritigenin results in increased activity of CASP9 protein
CTD PMID:16158945, PMID:23747687, PMID:25094029 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:25450236 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cckar cholecystokinin A receptor multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] CTD PMID:27702603 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO isoliquiritigenin results in decreased expression of CCND2 mRNA CTD PMID:27702603 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO isoliquiritigenin results in decreased expression of CCNE2 mRNA CTD PMID:27702603 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein CTD PMID:27702603 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO isoliquiritigenin results in decreased expression of CDKN1B mRNA CTD PMID:27702603 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO isoliquiritigenin results in decreased expression of CDKN1C mRNA CTD PMID:27702603 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein] CTD PMID:27117918 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein] CTD PMID:18295200 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA] CTD PMID:25026504 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO isoliquiritigenin results in decreased expression of CYP17A1 mRNA CTD PMID:27773742 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO isoliquiritigenin results in decreased expression of CYP19A1 mRNA CTD PMID:27773742 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:25110319 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
isoliquiritigenin results in decreased activity of CYP1A2 protein
CTD PMID:25110319, PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
isoliquiritigenin results in increased expression of CYP1B1 mRNA
CTD PMID:25110319, PMID:26134484 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO isoliquiritigenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] CTD PMID:25450236 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein] CTD PMID:27117918 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 increases expression ISO isoliquiritigenin results in increased expression of GADD45GIP1 mRNA CTD PMID:27702603 NCBI chr19:25,946,979...25,949,528
Ensembl chr19:25,946,979...25,949,528
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] CTD PMID:19834288 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoliquiritigenin results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO isoliquiritigenin results in decreased expression of HSD17B1 mRNA CTD PMID:27773742 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Ifng interferon gamma multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]
CTD PMID:23942037, PMID:25026504, PMID:26134484 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein] CTD PMID:25026504 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein] CTD PMID:25026504 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:18295200, PMID:25026504 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] CTD PMID:27117918 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression
ISO TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein] CTD PMID:24369695 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:18295200 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:18295200 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein CTD PMID:27702603 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]
isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein
CTD PMID:25094029 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]
isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein
CTD PMID:25094029 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein] CTD PMID:25026504 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein] CTD PMID:18295200 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
decreases phosphorylation
ISO isoliquiritigenin results in increased expression of NFKBIA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
isoliquiritigenin results in decreased phosphorylation of NFKBIA protein
CTD PMID:15729620, PMID:18295200 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein] CTD PMID:18295200, PMID:19834288, PMID:25026504, PMID:26134484 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isoliquiritigenin results in increased expression of NQO1 protein CTD PMID:26473469 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
ISO isoliquiritigenin results in increased activity of NR1I2 protein
isoliquiritigenin results in increased expression of NR1I2 mRNA
CTD PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO isoliquiritigenin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein]
CTD PMID:23747687 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases phosphorylation ISO isoliquiritigenin results in decreased phosphorylation of PDK1 protein CTD PMID:25094029 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO isoliquiritigenin results in decreased expression of PLA2G5 mRNA CTD PMID:23747687 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein] CTD PMID:27117918 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein CTD PMID:25094029 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO isoliquiritigenin results in decreased expression of PTGS1 mRNA CTD PMID:25094029 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO
EXP
isoliquiritigenin results in decreased expression of PTGS2 mRNA
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
CTD PMID:18295200, PMID:23747687, PMID:25026504, PMID:25450236 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein] CTD PMID:27117918 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity
ISO isoliquiritigenin affects the localization of RELA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]
isoliquiritigenin results in decreased activity of RELA protein
CTD PMID:15729620, PMID:18295200 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
isoliquiritigenin results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein] CTD PMID:27117918 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:19834288 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity
EXP [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance ISO SOD2 protein affects the susceptibility to isoliquiritigenin CTD PMID:23526725 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO isoliquiritigenin results in increased expression of STAR mRNA CTD PMID:27773742 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein] CTD PMID:25026504 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein] CTD PMID:25026504 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD PMID:18295200, PMID:25026504, PMID:25450236, PMID:26134484 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO isoliquiritigenin results in increased expression of TRP53 mRNA CTD PMID:27702603 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
okanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO okanin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO okanin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
phlorizin chalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO isosalipurposide results in increased expression of HMOX1 protein CTD PMID:26028482 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO MAPK1 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein] CTD PMID:26028482 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO MAPK3 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein] CTD PMID:26028482 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO isosalipurposide affects the localization of NFE2L2 protein
MAPK1 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein]; MAPK3 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein]
CTD PMID:26028482 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
sappanchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO sappanchalcone affects the localization of AIFM1 protein CTD PMID:32590072 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sappanchalcone results in increased expression of BAX protein CTD PMID:21963806, PMID:32590072 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sappanchalcone results in decreased expression of BCL2 protein CTD PMID:21963806, PMID:32590072 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO sappanchalcone results in increased activity of CASP3 protein
sappanchalcone results in increased cleavage of CASP3 protein
CTD PMID:21963806, PMID:32590072 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases cleavage ISO sappanchalcone results in increased cleavage of CASP7 protein CTD PMID:32590072 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases cleavage ISO sappanchalcone results in increased cleavage of CASP8 protein CTD PMID:32590072 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
ISO sappanchalcone results in increased activity of CASP9 protein
sappanchalcone results in increased cleavage of CASP9 protein
CTD PMID:21963806, PMID:32590072 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO sappanchalcone results in increased phosphorylation of MAPK8 protein CTD PMID:21963806 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sappanchalcone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:21963806 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO sappanchalcone results in increased cleavage of PARP1 protein CTD PMID:32590072 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sappanchalcone affects the localization of RELA protein CTD PMID:21963806 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO sappanchalcone results in increased expression of TP53 protein
sappanchalcone results in increased expression of and results in increased phosphorylation of TP53 protein
CTD PMID:21963806, PMID:32590072 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
trans-chalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Chalcone binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor affects binding EXP Chalcone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Chalcone results in decreased activity of CA1 protein CTD PMID:30431690 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Chalcone results in decreased activity of CA2 protein CTD PMID:30431690 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein] CTD PMID:20620131 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein] CTD PMID:20620131 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO Chalcone results in increased cleavage of CASP9 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]
CTD PMID:20620131 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation EXP CYP1A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation EXP CYP1A2 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation EXP CYP2C6V1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chalcone analog results in increased expression of GCLM mRNA; Chalcone analog results in increased expression of GCLM protein CTD PMID:31299238 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hat1 histone acetyltransferase 1 decreases activity ISO Chalcone analog results in decreased activity of HAT1 protein CTD PMID:22155221 NCBI chr 3:58,022,395...58,070,067
Ensembl chr 3:58,022,238...58,070,068
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22155221 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22155221 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155221 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22155221 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:22155221 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects response to substance
ISO Chalcone promotes the reaction [MYC protein results in increased abundance of Reactive Oxygen Species]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]
MYC protein affects the susceptibility to Chalcone
CTD PMID:20620131 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Chalcone analog results in decreased ubiquitination of and results in decreased degradation of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione] CTD PMID:31299238 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22155221 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155221 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Chalcone analog results in increased expression of NQO1 mRNA; Chalcone analog results in increased expression of NQO1 protein CTD PMID:31299238 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Chalcone results in increased cleavage of PARP1 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]
CTD PMID:20620131 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Chalcone analog results in increased expression of PPARG mRNA CTD PMID:28528971 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of Chalcone CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased phosphorylation of RELA protein] which results in increased acetylation of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22155221 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Chalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22155221 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
xanthohumol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; xanthohumol binds to and results in decreased activity of ABCC5 protein; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA] CTD PMID:23994090 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
increases expression
ISO xanthohumol results in increased activity of ALPL protein
xanthohumol results in increased expression of ALPL mRNA
CTD PMID:16019205 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of BAX protein] CTD PMID:31714664 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
xanthohumol results in decreased expression of BCL2; xanthohumol results in decreased expression of BCL2 protein
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]
CTD PMID:15995977, PMID:23562496, PMID:26297991, PMID:31714664 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:23994090 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity
ISO
EXP
xanthohumol results in increased cleavage of and results in increased activity of CASP3 protein
xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of CASP3 protein]
xanthohumol results in decreased activity of CASP3 protein
xanthohumol results in increased activity of CASP3 protein
CTD PMID:15995977, PMID:26297991, PMID:27317025, PMID:30240731, PMID:31714664 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP7 protein
xanthohumol results in increased activity of CASP7 protein
CTD PMID:15995977, PMID:30240731 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein
xanthohumol results in increased activity of CASP8 protein
CTD PMID:15995977, PMID:26297991 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP9 protein
xanthohumol results in increased activity of CASP9 protein
CTD PMID:15995977, PMID:26297991 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] CTD PMID:30849340 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
xanthohumol results in decreased expression of CCND1
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]
CTD PMID:26297991, PMID:27317025, PMID:31714664 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO xanthohumol results in increased expression of CDKN1A CTD PMID:26297991, PMID:27317025 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA] CTD PMID:23994090 NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein CTD PMID:27317025 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cryz crystallin zeta increases activity ISO xanthohumol results in increased activity of CRYZ protein CTD PMID:17590382 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] CTD PMID:31714664 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsk cathepsin K multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:23994090 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]
xanthohumol results in decreased activity of CYP1A1 protein
xanthohumol results in increased expression of CYP1A1 mRNA
CTD PMID:22138251, PMID:23503627 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO xanthohumol results in increased expression of CYP1A2 mRNA
xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
CTD PMID:22138251 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO xanthohumol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO xanthohumol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:23994090 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:23994090 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression
multiple interactions
ISO xanthohumol results in decreased expression of GSTA1 mRNA
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA
CTD PMID:22138251 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO xanthohumol results in increased expression of GSTP1 mRNA; xanthohumol results in increased expression of GSTP1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein; [Resveratrol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA
CTD PMID:23085367, PMID:32070777 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO xanthohumol results in increased expression of GSTT1 mRNA; xanthohumol results in increased expression of GSTT1 protein CTD PMID:23085367 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO xanthohumol results in increased expression of HMOX1 mRNA; xanthohumol results in increased expression of HMOX1 protein CTD PMID:23085367 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO xanthohumol results in decreased expression of ICAM1 protein CTD PMID:23503627 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein] CTD PMID:31629901 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO xanthohumol results in decreased expression of IL6 mRNA CTD PMID:16019205 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases activity
ISO xanthohumol results in decreased phosphorylation of MAPK1 protein
xanthohumol results in decreased activity of MAPK1 protein
CTD PMID:26297991, PMID:27317025 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
decreases phosphorylation
ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]
xanthohumol results in decreased activity of MAPK3 protein
xanthohumol results in decreased phosphorylation of MAPK3 protein
CTD PMID:23994090, PMID:26297991, PMID:27317025 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO xanthohumol results in decreased expression of and results in decreased activity of MMP9 protein
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]
xanthohumol results in decreased expression of MMP9 mRNA
CTD PMID:23562496, PMID:23994090 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of MYC protein] CTD PMID:31714664 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO xanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein CTD PMID:23503627 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA CTD PMID:22138251 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:23994090 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
increases expression
increases activity
ISO xanthohumol affects the localization of NFE2L2 protein
[xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein
xanthohumol results in increased expression of NFE2L2 mRNA; xanthohumol results in increased expression of NFE2L2 protein
xanthohumol results in increased activity of NFE2L2 protein
CTD PMID:23085367, PMID:32070777 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
decreases expression
ISO [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA
xanthohumol results in decreased activity of NFKB1 protein
xanthohumol results in decreased expression of NFKB1 mRNA
CTD PMID:32070777 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA] CTD PMID:31714664 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO xanthohumol results in increased expression of NQO1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [Resveratrol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein
xanthohumol results in increased expression of NQO1 mRNA; xanthohumol results in increased expression of NQO1 protein
CTD PMID:23085367, PMID:26473469, PMID:32070777 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA] CTD PMID:23994090 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO xanthohumol results in increased cleavage of PARP1 protein CTD PMID:15995977 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA] CTD PMID:23994090 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
decreases expression
ISO
EXP
xanthohumol results in decreased activity of PTGS2 protein
[xanthohumol co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of PTGS2 mRNA
xanthohumol results in decreased expression of PTGS2 mRNA
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]
CTD PMID:17590382, PMID:31714664, PMID:32070777 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pxn paxillin decreases expression ISO xanthohumol results in decreased expression of PXN protein CTD PMID:23503627 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
decreases expression
ISO [indole-3-carbinol co-treated with xanthohumol] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with xanthohumol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with xanthohumol] results in decreased activity of RELA protein; [Resveratrol co-treated with xanthohumol] results in decreased expression of RELA mRNA
xanthohumol results in decreased activity of RELA protein
xanthohumol results in decreased expression of RELA mRNA
CTD PMID:32070777 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO xanthohumol results in decreased expression of S100A4 protein CTD PMID:23503627 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Sele selectin E multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:23994090 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression
decreases expression
ISO xanthohumol results in increased expression of SULT1A1 mRNA
xanthohumol results in decreased expression of SULT1A1 mRNA
CTD PMID:22138251 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA] CTD PMID:23994090 NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO xanthohumol results in increased expression of TFF1 mRNA CTD PMID:16019205 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]
xanthohumol results in decreased susceptibility to TNFSF11 protein
CTD PMID:23994090 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 increases expression ISO xanthohumol results in increased expression of TP53; xanthohumol results in increased expression of TP53 mRNA; xanthohumol results in increased expression of TP53 protein CTD PMID:23085367, PMID:26297991, PMID:27317025 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] CTD PMID:23994090 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]
xanthohumol results in increased expression of UGT1A1 mRNA
CTD PMID:22138251 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vwf von Willebrand factor increases expression ISO xanthohumol results in increased expression of VWF mRNA CTD PMID:16019205 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          oxygen atom 19321
            oxygen molecular entity 19321
              flavonoids 10488
                chalcones 147
                  (+)-tephrosone 0
                  (E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                  1-(2,4-Dihydroxy-6-methoxy-3,5-dimethylphenyl)-3-phenyl-1-propanone 0
                  1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one 0
                  1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one 0
                  1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 0
                  1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(2,3,4,6-tetramethoxyphenyl)-2-propen-1-one 0
                  1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one 0
                  1-(3-nitrophenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 0
                  1-(4-ethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 0
                  1-(4-hydroxyphenyl)-3-[4-[(4-methyl-1,2,4-triazol-3-yl)thio]-3-nitrophenyl]-2-propen-1-one 0
                  1-(4-methylphenyl)-3-(6-quinolinyl)-2-propen-1-one 0
                  1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]-2-propen-1-one 0
                  1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one 0
                  1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 0
                  1-[4-hydroxy-2-methoxy-5-(3-methylbut-2-enyl)phenyl]-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-2-propen-1-one 0
                  1-phenyl-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 0
                  2',3,4,4',6'-pentahydroxychalcone + 0
                  2',3,4-trihydroxy-trans-chalcone + 0
                  2',4',4''-trihydroxy-3',6'',6''-trimethylpyrano[2'',3'':6',5']dihydrochalcone 0
                  2',4'-dihydroxy-3'-(2-hydroxy benzyl)-6'-methoxy chalcone 0
                  2',4'-dihydroxy-3'-methyl-6'-methoxychalcone 0
                  2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 12
                  2',4,4',6'-tetrahydroxychalcone + 3
                  2'-O-methylisoliquiritigenin 0
                  2'-hydroxychalcone 3
                  2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                  2-[(3,4-dihydroxyphenyl)-oxomethyl]-3-(4-hydroxy-3-iodo-5-methoxyphenyl)-2-propenenitrile 0
                  2-[4-[3-[2-[(4-methoxycarbonylphenyl)methoxy]phenyl]-1-oxoprop-2-enyl]phenoxy]acetic acid 0
                  3',6'-dihydroxy-2',4,4'-trimethoxy-chalcone 0
                  3'-(3-methyl-2-butenyl)-4'-O-beta-D-glucopyranosyl-4,2'-dihydroxychalcone 0
                  3'-geranyl-3,4,2',4'-tetrahydroxy-6'-methoxydihydrochalcone 0
                  3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-(2-hydroxy-4-methylphenyl)-2-propen-1-one 0
                  3-(2-methoxyphenyl)-1-phenyl-2-propen-1-one 0
                  3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile 0
                  3-(3-methylphenyl)-1-[4-(4-morpholinyl)phenyl]-2-propen-1-one 0
                  3-(4-hydroxyphenyl)-1-\{2,4,6-trihydroxy-3,5-bis(2S,3R,4R,5S,6R)[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl\}propan-1-one 0
                  3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)-2-propen-1-one 0
                  4'-O-methylbavachalcone 0
                  4'-O-methylxanthohumol 0
                  4'-hydroxychalcone 2
                  4-O-methylxanthohumol 0
                  4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid 0
                  4-benzyloxy-2'-hydroxy-3',4',5',6'-tetramethoxychalcone 0
                  4-chlorochalcone 0
                  4-hydroxychalcone 7
                  4-hydroxycordoin 0
                  7-methoxypraecansone B 0
                  Derricin 0
                  LSM-4240 0
                  N-[3-[3-(4-fluorophenyl)-1-oxoprop-2-enyl]phenyl]acetamide 0
                  N-[3-[3-(5-bromo-2-methoxyphenyl)-1-oxoprop-2-enyl]phenyl]propanamide 0
                  N-[4-[3-(2-methoxyphenyl)-1-oxoprop-2-enyl]phenyl]acetamide 0
                  [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid 0
                  abyssinone A 0
                  abyssinone C 0
                  abyssinone D 0
                  abyssinone VI 0
                  butein 17
                  candidachalcone 0
                  chalcone + 102
                  demethoxyisogemichalcone C 0
                  desmethylxanthohumol 0
                  flavokawain B 18
                  gemichalcone B 0
                  homoeriodictyol chalcone 0
                  isobavachalcone 2
                  isobutrin 0
                  isoliquiritigenin + 73
                  isoliquiritin 0
                  kuraridinol 0
                  mallotophilippen C 0
                  mallotophilippen D 0
                  mallotophilippen E + 0
                  naringin chalcone 0
                  obochalcolactone 0
                  okanin 2
                  oxygenated xanthohumol 0
                  phlorizin chalcone 4
                  pinocembrin chalcone 0
                  praecanson A 0
                  sappanchalcone 12
                  xanthogalenol 0
                  xanthohumol 62
                  xanthohumol B 0
                  xanthohumol D 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        alpha,beta-unsaturated ketone 8519
                                          enone 8519
                                            chalcones 147
                                              (+)-tephrosone 0
                                              (E)-4,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                                              1-(2,4-Dihydroxy-6-methoxy-3,5-dimethylphenyl)-3-phenyl-1-propanone 0
                                              1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one 0
                                              1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one 0
                                              1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 0
                                              1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(2,3,4,6-tetramethoxyphenyl)-2-propen-1-one 0
                                              1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one 0
                                              1-(3-nitrophenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 0
                                              1-(4-ethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 0
                                              1-(4-hydroxyphenyl)-3-[4-[(4-methyl-1,2,4-triazol-3-yl)thio]-3-nitrophenyl]-2-propen-1-one 0
                                              1-(4-methylphenyl)-3-(6-quinolinyl)-2-propen-1-one 0
                                              1-(5-chloro-2-hydroxyphenyl)-3-[4-(dimethylamino)phenyl]-2-propen-1-one 0
                                              1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one 0
                                              1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 0
                                              1-[4-hydroxy-2-methoxy-5-(3-methylbut-2-enyl)phenyl]-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-2-propen-1-one 0
                                              1-phenyl-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 0
                                              2',3,4,4',6'-pentahydroxychalcone + 0
                                              2',3,4-trihydroxy-trans-chalcone + 0
                                              2',4',4''-trihydroxy-3',6'',6''-trimethylpyrano[2'',3'':6',5']dihydrochalcone 0
                                              2',4'-dihydroxy-3'-(2-hydroxy benzyl)-6'-methoxy chalcone 0
                                              2',4'-dihydroxy-3'-methyl-6'-methoxychalcone 0
                                              2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 12
                                              2',4,4',6'-tetrahydroxychalcone + 3
                                              2'-O-methylisoliquiritigenin 0
                                              2'-hydroxychalcone 3
                                              2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                                              2-[(3,4-dihydroxyphenyl)-oxomethyl]-3-(4-hydroxy-3-iodo-5-methoxyphenyl)-2-propenenitrile 0
                                              2-[4-[3-[2-[(4-methoxycarbonylphenyl)methoxy]phenyl]-1-oxoprop-2-enyl]phenoxy]acetic acid 0
                                              3',6'-dihydroxy-2',4,4'-trimethoxy-chalcone 0
                                              3'-(3-methyl-2-butenyl)-4'-O-beta-D-glucopyranosyl-4,2'-dihydroxychalcone 0
                                              3'-geranyl-3,4,2',4'-tetrahydroxy-6'-methoxydihydrochalcone 0
                                              3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-(2-hydroxy-4-methylphenyl)-2-propen-1-one 0
                                              3-(2-methoxyphenyl)-1-phenyl-2-propen-1-one 0
                                              3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile 0
                                              3-(3-methylphenyl)-1-[4-(4-morpholinyl)phenyl]-2-propen-1-one 0
                                              3-(4-hydroxyphenyl)-1-\{2,4,6-trihydroxy-3,5-bis(2S,3R,4R,5S,6R)[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]phenyl\}propan-1-one 0
                                              3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)-2-propen-1-one 0
                                              4'-O-methylbavachalcone 0
                                              4'-O-methylxanthohumol 0
                                              4'-hydroxychalcone 2
                                              4-O-methylxanthohumol 0
                                              4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid 0
                                              4-benzyloxy-2'-hydroxy-3',4',5',6'-tetramethoxychalcone 0
                                              4-chlorochalcone 0
                                              4-hydroxychalcone 7
                                              4-hydroxycordoin 0
                                              7-methoxypraecansone B 0
                                              Derricin 0
                                              LSM-4240 0
                                              N-[3-[3-(4-fluorophenyl)-1-oxoprop-2-enyl]phenyl]acetamide 0
                                              N-[3-[3-(5-bromo-2-methoxyphenyl)-1-oxoprop-2-enyl]phenyl]propanamide 0
                                              N-[4-[3-(2-methoxyphenyl)-1-oxoprop-2-enyl]phenyl]acetamide 0
                                              [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid 0
                                              abyssinone A 0
                                              abyssinone C 0
                                              abyssinone D 0
                                              abyssinone VI 0
                                              butein 17
                                              candidachalcone 0
                                              chalcone + 102
                                              demethoxyisogemichalcone C 0
                                              desmethylxanthohumol 0
                                              flavokawain B 18
                                              gemichalcone B 0
                                              homoeriodictyol chalcone 0
                                              isobavachalcone 2
                                              isobutrin 0
                                              isoliquiritigenin + 73
                                              isoliquiritin 0
                                              kuraridinol 0
                                              mallotophilippen C 0
                                              mallotophilippen D 0
                                              mallotophilippen E + 0
                                              naringin chalcone 0
                                              obochalcolactone 0
                                              okanin 2
                                              oxygenated xanthohumol 0
                                              phlorizin chalcone 4
                                              pinocembrin chalcone 0
                                              praecanson A 0
                                              sappanchalcone 12
                                              xanthogalenol 0
                                              xanthohumol 62
                                              xanthohumol B 0
                                              xanthohumol D 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.