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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:disodium cromoglycate
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Accession:CHEBI:128458 term browser browse the term
Definition:An organic sodium salt that is the disodium salt of cromoglycic acid.
Synonyms:exact_synonym: disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate)
 related_synonym: DSCG;   Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan;   Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylate);   FPL-670;   Formula=C23H14Na2O11;   InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2;   InChIKey=VLARUOGDXDTHEH-UHFFFAOYSA-L;   Natrium cromoglicat;   SMILES=[Na+].[Na+].OC(COc1cccc2oc(cc(=O)c12)C([O-])=O)COc1cccc2oc(cc(=O)c12)C([O-])=O;   Sodium cromoglicate;   Sodium cromoglycate;   Sodium cromolyn;   Sodium salt of 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid;   disodium 5-[3-(2-carboxylato-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylate;   disodium 5-{3-[(2-carboxylato-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylate
 alt_id: CHEBI:106480;   CHEBI:3922;   CHEBI:3923
 xref: Beilstein:3647577;   CAS:15826-37-6;   KEGG:D00526
 xref_mesh: MESH:D004205
 xref: PMID:12001789;   PMID:19107959;   PMID:26176755;   PMID:26656593;   PMID:26871132;   PMID:26964003;   PMID:3128591


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disodium cromoglycate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions ISO [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of MRP4 protein] CTD PMID:35114312 PMID:36464070 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression
multiple interactions		 ISO Cromolyn Sodium results in increased expression of ABCG2 protein
Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein]		 CTD PMID:36464070 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein] CTD PMID:35114312 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Cromolyn Sodium results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adora3 adenosine A3 receptor decreases activity ISO Cromolyn Sodium results in decreased activity of ADORA3 protein CTD PMID:15641640 NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of AGT protein] CTD PMID:35114312 PMID:36464070 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein] CTD PMID:28732690 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein] CTD PMID:15033348 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Cst3 cystatin C multiple interactions ISO Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein] CTD PMID:35114312 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Cromolyn Sodium results in decreased expression of DNMT1 mRNA; Cromolyn Sodium results in decreased expression of DNMT1 protein CTD PMID:35961540 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Gpr35 G protein-coupled receptor 35 affects localization
multiple interactions		 ISO
EXP		 Cromolyn Sodium affects the localization of GPR35 protein
Cromolyn Sodium binds to and results in increased activity of GPR35 protein
2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]; Cromolyn Sodium binds to and results in increased activity of GPR35 protein; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]		 CTD PMID:20919992 PMID:22967846 NCBI chr 1:92,875,774...92,913,984
Ensembl chr 1:92,878,587...92,914,113 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of GPX1 protein] CTD PMID:36464070 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Ins1 insulin I increases expression EXP Cromolyn Sodium results in increased expression of INS1 protein CTD PMID:23784744 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Cromolyn Sodium results in decreased phosphorylation of MAPK1 protein CTD PMID:35961540 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Cromolyn Sodium results in decreased phosphorylation of MAPK3 protein		 CTD PMID:28732690 PMID:35961540 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Cromolyn Sodium results in decreased expression of METTL3 mRNA; Cromolyn Sodium results in decreased expression of METTL3 protein CTD PMID:35961540 NCBI chr14:52,532,298...52,548,555
Ensembl chr14:52,532,298...52,542,585 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA		 CTD PMID:14577597 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone] CTD PMID:1659878 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ren1 renin 1 structural multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of REN protein] CTD PMID:36464070 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Retn resistin decreases expression EXP Cromolyn Sodium results in decreased expression of RETN protein CTD PMID:23784744 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein] CTD PMID:36464070 NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein] CTD PMID:35114312 PMID:36464070 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein] CTD PMID:35114312 PMID:36464070 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SOD1 protein] CTD PMID:36464070 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein] CTD PMID:15033348 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases secretion		 ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein
Cromolyn Sodium results in increased secretion of TGFB1 protein
Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]		 CTD PMID:35007524 PMID:35114312 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      application 21776
        anti-asthmatic agent 9336
          anti-asthmatic drug 8760
            disodium cromoglycate 32
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  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            organic ion 10080
                              organic anion 3688
                                carboxylic acid anion 2524
                                  dicarboxylic acid anion 251
                                    dicarboxylic acid dianion 251
                                      cromoglycate(2-) 33
                                        disodium cromoglycate 32
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