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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:protein kinase C (PKC) signaling pathway
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Accession:PW:0000840 term browser browse the term
Definition:Protein kinase C constitutes a family of serine/threonine kinases activated by diacylglycerol (DAG) and calcium whose signal transduction plays important roles in many cellular processes. Ligand-activated G protein-coupled receptors, via the Galphaq pathway, stimulate phospholipase C, which cleaves PIP2 into DAG and IP3. IP3 promotes calcium release.
Synonyms:related_synonym: protein kinase C signaling
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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:102,016,074...102,055,143 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO RGD PMID:19934406 RGD:5131489 NCBI chr 8:27,954,292...27,966,935
Ensembl chr 8:27,948,016...27,983,931 		JBrowse link
G Copb1 coat protein complex I subunit beta 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr 1:177,838,751...177,876,688
Ensembl chr 1:177,838,752...177,872,840 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 ISO RGD PMID:15380937 RGD:5131492 NCBI chr12:16,710,601...16,723,734
Ensembl chr12:16,710,601...16,723,734 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:19934406 RGD:5131489 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267 		JBrowse link
G Ldb3 LIM domain binding 3 ISO RGD PMID:18491053 PMID:15380937 RGD:5131491, RGD:5131492 NCBI chr16:9,862,161...9,926,338
Ensembl chr16:9,862,161...9,926,985 		JBrowse link
G Pard3 par-3 family cell polarity regulator ISO RGD PMID:16525119 RGD:5132275 NCBI chr19:71,977,420...72,527,273
Ensembl chr19:71,977,470...72,526,941 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO RGD PMID:16525119 RGD:5132275 NCBI chr19:50,499,420...50,502,301
Ensembl chr19:50,499,442...50,502,674 		JBrowse link
G Pard6b par-6 family cell polarity regulator beta ISO RGD PMID:16525119 RGD:5132275 NCBI chr 3:177,209,429...177,230,509
Ensembl chr 3:177,209,258...177,230,510 		JBrowse link
G Pard6g par-6 family cell polarity regulator gamma ISO RGD PMID:16525119 RGD:5132275 NCBI chr18:75,772,992...75,840,041
Ensembl chr18:75,772,955...75,840,041 		JBrowse link
G Pcnt pericentrin ISO RGD PMID:15380937 RGD:5131492 NCBI chr20:12,189,767...12,278,179
Ensembl chr20:12,192,353...12,278,178 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO RGD PMID:19934406 RGD:5131489 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 IMP
ISO 		RGD PMID:20819118 PMID:18511290 RGD:8693633, RGD:5131497 NCBI chr13:22,823,132...23,045,619
Ensembl chr13:22,823,132...23,045,619 		JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 ISO RGD PMID:18511290 RGD:5131497 NCBI chr19:54,744,581...54,811,258
Ensembl chr19:54,744,581...54,812,259 		JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:112,677,322...112,697,257 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Plcb2 phospholipase C, beta 2 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221 		JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583 		JBrowse link
G Plcb4 phospholipase C, beta 4 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113 		JBrowse link
G Prkca protein kinase C, alpha ISO RGD PMID:19934406 RGD:5131489 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:19934406 RGD:5131489 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Prkcd protein kinase C, delta ISO RGD PMID:19934406 RGD:5131489 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Prkce protein kinase C, epsilon ISO RGD PMID:19934406 RGD:5131489 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288 		JBrowse link
G Prkcg protein kinase C, gamma ISO RGD PMID:19934406 RGD:5131489 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
G Prkch protein kinase C, eta ISO
IMP 		RGD PMID:19934406 PMID:9677361 RGD:5131489, RGD:5131657 NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:98,027,646...98,226,477 		JBrowse link
G Prkci protein kinase C, iota ISO RGD PMID:19934406 PMID:16525119 RGD:5131489, RGD:5132275 NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:114,250,398...114,310,784 		JBrowse link
G Prkcq protein kinase C, theta ISO RGD PMID:19934406 RGD:5131489 NCBI chr17:72,156,215...72,288,508
Ensembl chr17:72,156,215...72,288,508 		JBrowse link
G Prkcz protein kinase C, zeta ISO
IMP 		RGD PMID:19934406 PMID:20570724 PMID:16525119 RGD:5131489, RGD:5131661, RGD:5132275 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948 		JBrowse link
G Rasa1 RAS p21 protein activator 1 IMP RGD PMID:7588705 RGD:10002727 NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway involving second messengers 359
        protein kinase C (PKC) signaling pathway 32
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      kinase mediated signaling pathway 602
        serine/threonine-specific kinase mediated signaling pathway 476
          protein kinase C (PKC) signaling pathway 32
paths to the root