Foxo1 (forkhead box O1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Foxo1 (forkhead box O1) Rattus norvegicus
Analyze
Symbol: Foxo1
Name: forkhead box O1
RGD ID: 620283
Description: Enables DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Used to study metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1); PARTICIPATES IN interleukin-6 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fkhr; forkhead box O1A; forkhead box O1A (rhabdomyosarcoma); forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Foxo1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82138,462,974 - 138,541,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2138,462,697 - 138,541,419 (+)EnsemblGRCr8
mRatBN7.22136,312,168 - 136,390,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2136,312,168 - 136,387,790 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2142,888,018 - 142,963,653 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02141,000,299 - 141,075,747 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02135,636,484 - 135,712,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02141,451,234 - 141,527,016 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)Ensemblrn6Rnor6.0
Rnor_5.02161,140,308 - 161,215,605 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42141,127,345 - 141,203,446 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2130,806,706 - 130,882,185 (+)NCBICelera
RGSC_v3.12141,077,916 - 141,151,838 (+)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-voacangine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(9E,11E)-octadecadienoic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,2-dichloroethane  (ISO)
1,8-cineole  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6alpha-methylprednisolone  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-phellandrene  (ISO)
AM-251  (ISO)
amidotrizoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acids  (EXP)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camphor  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
echinacoside  (EXP,ISO)
elemental selenium  (EXP)
emodin  (ISO)
empagliflozin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
Geniposide  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
GSK2656157  (ISO)
herbicide  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroxyurea  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
medroxyprogesterone acetate  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
myo-inositol hexakisphosphate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perifosine  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
picloram  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pomalidomide  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin  (ISO)
procyanidin B2  (ISO)
progesterone  (ISO)
propofol  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
sabinene  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
spathulenol  (ISO)
spirotetramat  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulpiride  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tannic acid  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichlopyr  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
xanthosine  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO,ISS)
autophagy  (IEA)
blood vessel development  (ISO)
cell differentiation  (IEA)
cellular response to dexamethasone stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hyperoxia  (ISO,ISS)
cellular response to insulin stimulus  (IEA,ISO,ISS)
cellular response to nitric oxide  (IEA,ISO,ISS)
cellular response to oxidative stress  (IEA,ISO,ISS)
cellular response to starvation  (ISO,ISS)
DNA damage response  (IEA,ISO,ISS)
enamel mineralization  (IEP)
gene expression  (ISO)
glucose homeostasis  (ISO)
insulin receptor signaling pathway  (IBA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (IMP)
negative regulation of fat cell differentiation  (IEA,ISO,ISS)
negative regulation of gene expression  (ISO)
negative regulation of insulin secretion  (IEA,ISO,ISS)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neuronal stem cell population maintenance  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of autophagy  (ISO,ISS)
positive regulation of complement-dependent cytotoxicity  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of gluconeogenesis  (IBA,ISO,ISS)
positive regulation of protein catabolic process  (ISO,ISS)
positive regulation of smooth muscle cell apoptotic process  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gluconeogenesis  (ISO)
regulation of neural precursor cell proliferation  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
regulation of transcription initiation by RNA polymerase II  (IMP)
response to fatty acid  (IEA,ISO,ISS)
response to fluoride  (IEP)
response to insulin  (IEP,ISO)

Cellular Component
cytoplasm  (IDA,IEA,ISO,ISS)
cytosol  (ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. Altomonte J, etal., J Clin Invest. 2004 Nov;114(10):1493-503.
2. Excessive fluoride reduces Foxo1 expression in dental epithelial cells of the rat incisor. Gao J, etal., Eur J Oral Sci. 2014 Oct;122(5):317-23. doi: 10.1111/eos.12148. Epub 2014 Sep 3.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Transcriptional genomics associates FOX transcription factors with human heart failure. Hannenhalli S, etal., Circulation. 2006 Sep 19;114(12):1269-76. Epub 2006 Sep 4.
6. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
7. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
8. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. Huang ZP, etal., J Clin Invest. 2015 Nov 2;125(11):4122-34. doi: 10.1172/JCI82423. Epub 2015 Oct 5.
9. Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular carcinoma tumorigenesis in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH). Jia Y, etal., Exp Mol Pathol. 2018 Aug;105(1):144-149. doi: 10.1016/j.yexmp.2018.07.005. Epub 2018 Jul 17.
10. NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in hepatocellular carcinoma and thereby suppresses tumor proliferation and invasion. Jiang J, etal., J Biol Chem. 2017 Nov 24;292(47):19146-19159. doi: 10.1074/jbc.M117.793760. Epub 2017 Sep 27.
11. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Kloting N, etal., Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):146-54.
12. C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. Li F, etal., J Biol Chem. 2009 Jul 24;284(30):20090-8. doi: 10.1074/jbc.M109.017046. Epub 2009 May 29.
13. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
14. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. McClung JM, etal., J Physiol. 2007 Nov 15;585(Pt 1):203-15. Epub 2007 Oct 4.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Nagashima T, etal., Mol Pharmacol. 2010 Nov;78(5):961-70. doi: 10.1124/mol.110.065714. Epub 2010 Aug 24.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
19. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Paik JH, etal., Cell. 2007 Jan 26;128(2):309-23. doi: 10.1016/j.cell.2006.12.029.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. The vertebrae of prematurely aging mice as a skeletal model of involutional osteoporosis. Portal-Nunez S, etal., Histol Histopathol. 2013 Nov;28(11):1473-81. Epub 2013 May 15.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats. Ropelle ER, etal., J Physiol. 2009 May 1;587(Pt 9):2069-76. doi: 10.1113/jphysiol.2008.164202. Epub 2009 Mar 9.
28. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
29. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. Schmoll D, etal., J Biol Chem 2000 Nov 17;275(46):36324-33.
30. Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein. Wu K, etal., Endocrinology. 2010 Aug;151(8):3566-76. doi: 10.1210/en.2010-0204. Epub 2010 May 25.
31. Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats. Xie X, etal., J Diabetes Res. 2018 Aug 16;2018:6254340. doi: 10.1155/2018/6254340. eCollection 2018.
32. The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress. Yan L, etal., Biochem J. 2012 Jun 1;444(2):239-47. doi: 10.1042/BJ20111606.
33. Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. Zhang X, etal., Endocrinology. 2009 Sep;150(9):4065-73. doi: 10.1210/en.2009-0343. Epub 2009 May 14.
Additional References at PubMed
PMID:7862145   PMID:10871843   PMID:11237865   PMID:11311120   PMID:11353388   PMID:11875118   PMID:12228231   PMID:12488434   PMID:12724332   PMID:12783775   PMID:12857750   PMID:12891709  
PMID:12969136   PMID:14500580   PMID:14565960   PMID:14978268   PMID:15057822   PMID:15184386   PMID:15256269   PMID:15905404   PMID:16027169   PMID:16455781   PMID:16604086   PMID:16670091  
PMID:16952979   PMID:17090532   PMID:17107961   PMID:17317782   PMID:17482685   PMID:17550780   PMID:17681146   PMID:17950246   PMID:17972158   PMID:17986386   PMID:18162514   PMID:18202312  
PMID:18293098   PMID:18304430   PMID:18356527   PMID:18388859   PMID:18420577   PMID:18497885   PMID:18555008   PMID:18680538   PMID:18765640   PMID:18815134   PMID:18972406   PMID:19037106  
PMID:19168598   PMID:19221179   PMID:19332486   PMID:19690465   PMID:19696026   PMID:19696738   PMID:19837876   PMID:19850732   PMID:19896444   PMID:19959771   PMID:20033367   PMID:20079455  
PMID:20081110   PMID:20543840   PMID:20973227   PMID:21097394   PMID:21149440   PMID:21196578   PMID:21281824   PMID:21317886   PMID:21332026   PMID:21385937   PMID:21545834   PMID:21549807  
PMID:21817126   PMID:21972093   PMID:21991327   PMID:22012952   PMID:22086006   PMID:22209681   PMID:22511764   PMID:22733486   PMID:22940604   PMID:23002242   PMID:23152492   PMID:23247844  
PMID:23500899   PMID:23555761   PMID:23788637   PMID:23803610   PMID:23906066   PMID:24212932   PMID:24280217   PMID:24440707   PMID:24807827   PMID:24967006   PMID:25062567   PMID:25147338  
PMID:25288788   PMID:25344740   PMID:25399953   PMID:25796372   PMID:26029993   PMID:26123583   PMID:26342801   PMID:26361145   PMID:26518453   PMID:26727601   PMID:26935354   PMID:26944797  
PMID:26962001   PMID:27288017   PMID:27328024   PMID:27542118   PMID:27547294   PMID:27577745   PMID:27663689   PMID:27979659   PMID:28118532   PMID:28283331   PMID:28536427   PMID:28738025  
PMID:28790135   PMID:29446047   PMID:30217602   PMID:30345866   PMID:30360646   PMID:30376839   PMID:30411113   PMID:30551436   PMID:30629029   PMID:30654931   PMID:31223614   PMID:31582213  
PMID:31871187   PMID:31889343   PMID:32450616   PMID:32620714   PMID:32654176   PMID:32845875   PMID:32868747   PMID:33049085   PMID:33108705   PMID:33296068   PMID:33349993   PMID:33355375  
PMID:33722671   PMID:33840298   PMID:33875617   PMID:33955666   PMID:34194603   PMID:34661985   PMID:34673854   PMID:34761005   PMID:34845564   PMID:34871948   PMID:34943780   PMID:35198097  
PMID:35688305   PMID:35947892   PMID:36581217   PMID:36625880   PMID:36701897   PMID:36916106   PMID:37116560   PMID:37329542   PMID:37391062   PMID:37542853   PMID:37961034   PMID:38063102  
PMID:38149787   PMID:38189995   PMID:38358361   PMID:38518842   PMID:38943142  


Genomics

Comparative Map Data
Foxo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82138,462,974 - 138,541,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2138,462,697 - 138,541,419 (+)EnsemblGRCr8
mRatBN7.22136,312,168 - 136,390,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2136,312,168 - 136,387,790 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2142,888,018 - 142,963,653 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02141,000,299 - 141,075,747 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02135,636,484 - 135,712,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02141,451,234 - 141,527,016 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)Ensemblrn6Rnor6.0
Rnor_5.02161,140,308 - 161,215,605 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42141,127,345 - 141,203,446 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2130,806,706 - 130,882,185 (+)NCBICelera
RGSC_v3.12141,077,916 - 141,151,838 (+)NCBI
Cytogenetic Map2q26NCBI
FOXO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381340,555,667 - 40,666,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1340,555,667 - 40,667,612 (-)Ensemblhg38GRCh38
GRCh371341,129,804 - 41,240,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,027,801 - 40,138,734 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341340,027,816 - 40,138,734NCBI
Celera1322,187,272 - 22,298,190 (-)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1321,931,318 - 22,042,054 (-)NCBIHuRef
CHM1_11341,097,585 - 41,208,493 (-)NCBICHM1_1
T2T-CHM13v2.01339,774,673 - 39,885,620 (-)NCBIT2T-CHM13v2.0
Foxo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39352,175,758 - 52,257,530 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl352,175,757 - 52,260,642 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38352,268,337 - 52,350,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl352,268,336 - 52,353,221 (+)Ensemblmm10GRCm38
MGSCv37352,072,259 - 52,154,031 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36352,356,303 - 52,437,467 (+)NCBIMGSCv36mm8
Celera352,001,471 - 52,082,927 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map323.19NCBI
Foxo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,797,840 - 5,887,001 (+)Ensembl
ChiLan1.0NW_0049554315,797,359 - 5,890,758 (+)NCBIChiLan1.0ChiLan1.0
FOXO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21440,071,100 - 40,189,248 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11331,174,663 - 31,292,810 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01321,763,729 - 21,874,279 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11340,351,680 - 40,462,439 (-)NCBIPanPan1.1PanPan1.1panPan2
FOXO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.125603,433 - 706,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl25603,543 - 702,825 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha25700,411 - 804,085 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.025700,621 - 804,447 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25700,891 - 800,342 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.125603,299 - 707,347 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025596,320 - 700,167 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025663,424 - 767,068 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Foxo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,725,964 - 161,815,163 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365655,210,014 - 5,302,436 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365655,210,014 - 5,299,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,317,124 - 15,410,473 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11115,317,222 - 15,410,059 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21115,548,296 - 15,550,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1318,916,849 - 19,027,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl318,920,651 - 19,027,707 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605725,219,605 - 25,330,187 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247481,413,983 - 1,529,992 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247481,413,754 - 1,529,646 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Foxo1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13102,101,033 - 102,175,674 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Foxo1
306 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:111
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000018244
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
AW531775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22136,315,443 - 136,315,658 (+)MAPPERmRatBN7.2
Rnor_6.02141,454,510 - 141,454,724NCBIRnor6.0
Rnor_5.02161,143,584 - 161,143,798UniSTSRnor5.0
RGSC_v3.42141,130,621 - 141,130,835UniSTSRGSC3.4
Celera2130,809,982 - 130,810,196UniSTS
RH 3.4 Map2850.8UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018244   ⟹   ENSRNOP00000018244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2138,462,697 - 138,541,419 (+)Ensembl
mRatBN7.2 Ensembl2136,312,168 - 136,387,790 (+)Ensembl
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)Ensembl
RefSeq Acc Id: NM_001191846   ⟹   NP_001178775
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82138,462,974 - 138,538,607 (+)NCBI
mRatBN7.22136,312,168 - 136,387,790 (+)NCBI
Rnor_6.02141,451,234 - 141,527,016 (+)NCBI
Rnor_5.02161,140,308 - 161,215,605 (+)NCBI
Celera2130,806,706 - 130,882,185 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103268   ⟹   XP_038959196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82138,482,809 - 138,541,420 (+)NCBI
mRatBN7.22136,348,113 - 136,390,603 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178775 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959196 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG09779 (Get FASTA)   NCBI Sequence Viewer  
  EDM14970 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018244
  ENSRNOP00000018244.3
GenBank Protein G3V7R4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178775   ⟸   NM_001191846
- UniProtKB: G3V7R4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018244   ⟸   ENSRNOT00000018244
RefSeq Acc Id: XP_038959196   ⟸   XM_039103268
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7R4-F1-model_v2 AlphaFold G3V7R4 1-649 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620283 AgrOrtholog
BioCyc Gene G2FUF-53120 BioCyc
Ensembl Genes ENSRNOG00000013397 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018244 ENTREZGENE
  ENSRNOT00000018244.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro FH_FOXO1 UniProtKB/Swiss-Prot
  Fork_head_dom UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX-bd UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:84482 UniProtKB/Swiss-Prot
NCBI Gene 84482 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN O UniProtKB/Swiss-Prot
  FORKHEAD BOX PROTEIN O1 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX_bdg UniProtKB/Swiss-Prot
PharmGKB FOXO1A RGD
PhenoGen Foxo1 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013397 RatGTEx
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Foxo1  forkhead box O1  Foxo1a  forkhead box O1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Foxo1a  forkhead box O1A    forkhead box O1A (rhabdomyosarcoma)  Name updated 1299863 APPROVED
2002-08-07 Foxo1a  forkhead box O1A (rhabdomyosarcoma)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process induces the glucose-6-phosphatase promoter activity via interaction with an insulin response unit (IRU) 632718