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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases acetylationISORGD:7371566480464CTDDoxorubicin results in increased acetylation of FOXO1 protein

PMID:25665036
increases expressionISORGD:7371566480464CTDDoxorubicin results in increased expression of FOXO1 mRNA

PMID:28329872
increases phosphorylationISORGD:7371556480464CTDDoxorubicin results in increased phosphorylation of FOXO1 protein

PMID:17935137
multiple interactionsISORGD:7371556480464CTDwortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]

PMID:17935137
multiple interactionsISORGD:7371566480464CTD6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]], resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein], sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]

PMID:25665036
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.