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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7371556480464CTDProgesterone results in increased expression of FOXO1 mRNA

PMID:20864642
multiple interactionsISORGD:7371556480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]], Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]], Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]], Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]

PMID:21768169
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.