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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:17154
Term: nicotinamide
Definition: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Chemical ID: MESH:D009536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDNiacinamide inhibits the reaction [Dexamethasone results in decreased acetylation of FOXO1 protein], Niacinamide inhibits the reaction [FOXO1 protein binds to SIRT1 protein]

PMID:20181797
multiple interactionsISORGD:7371556480464CTD[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein, Niacinamide results in increased expression of and results in increased acetylation of FOXO1 protein

PMID:26712469
multiple interactionsISORGD:7371566480464CTDNiacinamide inhibits the reaction [FOXO1 protein results in increased expression of G6PC mRNA], Niacinamide inhibits the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]

PMID:16917544
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.