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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo1
Name: forkhead box O1
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:7371556480464CTDZinc Sulfate affects the localization of FOXO1 protein

PMID:16973122
increases phosphorylationISORGD:7371556480464CTDZinc Sulfate results in increased phosphorylation of FOXO1 protein

PMID:16973122
multiple interactionsISORGD:7371556480464CTDwortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein], wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]

PMID:16973122
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.